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Protein
Submitted name:

Uncharacterized protein

Gene

Adam8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Zinc; catalyticPROSITE-ProRule annotation1
Active sitei79PROSITE-ProRule annotation1
Metal bindingi82Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi88Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:Adam8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107825. Adam8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei408 – 432HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi210 ↔ 230PROSITE-ProRule annotation
Disulfide bondi364 ↔ 374PROSITE-ProRule annotation
Disulfide bondi382 ↔ 391PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ3UA33.
PeptideAtlasiQ3UA33.
PRIDEiQ3UA33.

Structurei

3D structure databases

ProteinModelPortaliQ3UA33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 144Peptidase M12BInterPro annotationAdd BLAST144
Domaini152 – 238DisintegrinInterPro annotationAdd BLAST87
Domaini360 – 392EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOVERGENiHBG103970.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom_sf.
IPR001590. Peptidase_M12B.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q3UA33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KFYISRYANV TLENFLSWRE QNLQGQHPHD NVQLITGVDF IGSTVGLAKV
60 70 80 90 100
SALCSRHSGA VNQDHSKNSI GVASTMAHEL GHNLGMSHDE DIPGCYCPEP
110 120 130 140 150
REGGGCIMTE SIGSKFPRIF SRCSKIDLES FVTKPQTGCL TNVPDVNRFV
160 170 180 190 200
GGPVCGNLFV EHGEQCDCGT PQDCQNPCCN ATTCQLVKGA ECASGTCCHE
210 220 230 240 250
CKVKPAGEVC RLSKDKCDLE EFCDGRKPTC PEDAFQQNGT PCPGGYCFDG
260 270 280 290 300
SCPTLAQQCR DLWGPGARVA ADSCYTFSIP PGCNGRMYSG RINRCGALYC
310 320 330 340 350
EGGQKPLERS FCTFSSNHGV CHALGTGSNI DTFELVLQGT KCEEGKVCMD
360 370 380 390 400
GSCQDLRVYR SENCSAKCNN HGVCNHKREC HCHKGWAPPN CVQRLADVSD
410 420 430 440 450
EQAASTSLPV SVIVVLVILV AAMVIVAGIV IYRKAPRQIQ RRSVAPKPIS
460 470 480 490 500
GLSNPLFYTR DSSLPAKNRP PDPSETVSTN QPPRPIVKPK RPPPAPPGAV
510 520 530 540 550
SSSPLPVPVY APKIPNQFRP DPPTKPLPEL KPKQVKPTFA PPTPPVKPGT
560 570
GGTVPGATQG AGEPKVALKV PIQKR
Length:575
Mass (Da):61,725
Last modified:October 11, 2005 - v1
Checksum:i17AFBF2A1BFBF7BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK151535 mRNA. Translation: BAE30482.1.
UniGeneiMm.15969.

Similar proteinsi

Entry informationi

Entry nameiQ3UA33_MOUSE
AccessioniPrimary (citable) accession number: Q3UA33
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation