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Q3U9N9

- MOT10_MOUSE

UniProt

Q3U9N9 - MOT10_MOUSE

Protein

Monocarboxylate transporter 10

Gene

Slc16a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells.1 Publication

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 10
    Short name:
    MCT 10
    Alternative name(s):
    Aromatic amino acid transporter 1
    Solute carrier family 16 member 10
    T-type amino acid transporter 1
    Gene namesi
    Name:Slc16a10
    Synonyms:Mct10, Tat1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1919722. Slc16a10.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Basolateral cell membrane 1 Publication
    Note: Detected in basolateral membrane of kidney proximal tubule starting at he beginning of the proximal tubule epithelium within the glomerular capsule and extending to the S1 and S2 segments. Localizes also to the basolateral membrane of small intestine enterocytes and to sinusoidal side of perivenous hepatocytes.

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Monocarboxylate transporter 10PRO_0000314254Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei495 – 4951Phosphoserine1 Publication
    Modified residuei498 – 4981Phosphoserine1 Publication
    Modified residuei501 – 5011Phosphoserine1 Publication

    Post-translational modificationi

    Not N-glycosylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ3U9N9.
    PaxDbiQ3U9N9.
    PRIDEiQ3U9N9.

    Expressioni

    Tissue specificityi

    Highly expressed in small intestine, particularly in jejunum and ileum, scarcely in colon and substantially in kidney, liver and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ3U9N9.
    GenevestigatoriQ3U9N9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U9N9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 11127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1419ExtracellularSequence Analysis
    Topological domaini163 – 1686CytoplasmicSequence Analysis
    Topological domaini190 – 20112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23210CytoplasmicSequence Analysis
    Topological domaini254 – 29138ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 32614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini348 – 36215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini384 – 3841CytoplasmicSequence Analysis
    Topological domaini406 – 41611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini438 – 44811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini470 – 51243ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG321880.
    GeneTreeiENSGT00740000115479.
    HOGENOMiHOG000046644.
    HOVERGENiHBG006387.
    InParanoidiQ3U9N9.
    KOiK08187.
    OMAiHLMKHVN.
    OrthoDBiEOG7KWSH8.
    PhylomeDBiQ3U9N9.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3U9N9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPSQEEPAA ERETNEAQPP GPAPSDDAPL PGPGPSDVSD VAAEKVEVEL    50
    TRSAGSEPPV PPEGGWGWLV MLAAMWCNGS VFGIQNAYGV LFVSMLDTFK 100
    AKDDDNMAFK TAWVGSLSMG MIFFCCPIVS VFTDMFGCRR TAVVGAAVGF 150
    IGLMSSSFVS SIEPLYLTYG IIFACGCSFA YQPSLVILGH YFKKRLGLVN 200
    GIVTAGSSVF TILLPLLLGN LISSVKLFNT LRILCIFMFV LFLAGFTYRP 250
    LVPSTKEKES GGSRSSFFSR RKLSPPKKVF NFALFKETTY AVWAAGIPLA 300
    LFGYFVPYVH LMNHVKERFQ DVNNKEVLFM CIGITSGVGR LLFGRIADYL 350
    PGVKKVYLQV LSFFFIGLMS MMIPLCSAFG ALIAVCLAMG LFDGCFISIM 400
    APIAFELVGP QDASQAIGFL LGFMSIPMTV GPPIAGLLHD KLGTYDVAFY 450
    LAGIPPFVGG VVLCLIPWIH SKKQRKISKN AGGEKMEKML ENQSSLLSGS 500
    SGIFKKDSAS II 512
    Length:512
    Mass (Da):55,320
    Last modified:October 11, 2005 - v1
    Checksum:i4EF7A1400C8E0B04
    GO
    Isoform 2 (identifier: Q3U9N9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         312-320: MNHVKERFQ → VSMHLWLCL
         321-512: Missing.

    Show »
    Length:320
    Mass (Da):34,718
    Checksum:iA60696B0242BDF35
    GO

    Sequence cautioni

    The sequence BAE38097.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2111T → I in BAE30275. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei312 – 3209MNHVKERFQ → VSMHLWLCL in isoform 2. 1 PublicationVSP_030252
    Alternative sequencei321 – 512192Missing in isoform 2. 1 PublicationVSP_030253Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050229 mRNA. Translation: BAC34135.1.
    AK151290 mRNA. Translation: BAE30275.1.
    AK151704 mRNA. Translation: BAE30627.1.
    AK157355 mRNA. Translation: BAE34061.1.
    AK165240 mRNA. Translation: BAE38097.1. Different initiation.
    AK165579 mRNA. Translation: BAE38270.1.
    CCDSiCCDS48543.1. [Q3U9N9-1]
    RefSeqiNP_001107804.1. NM_001114332.1. [Q3U9N9-1]
    NP_082523.1. NM_028247.4. [Q3U9N9-2]
    UniGeneiMm.186778.

    Genome annotation databases

    EnsembliENSMUST00000092566; ENSMUSP00000090227; ENSMUSG00000019838. [Q3U9N9-1]
    GeneIDi72472.
    KEGGimmu:72472.
    UCSCiuc007ewm.2. mouse. [Q3U9N9-1]
    uc007ewn.2. mouse. [Q3U9N9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050229 mRNA. Translation: BAC34135.1 .
    AK151290 mRNA. Translation: BAE30275.1 .
    AK151704 mRNA. Translation: BAE30627.1 .
    AK157355 mRNA. Translation: BAE34061.1 .
    AK165240 mRNA. Translation: BAE38097.1 . Different initiation.
    AK165579 mRNA. Translation: BAE38270.1 .
    CCDSi CCDS48543.1. [Q3U9N9-1 ]
    RefSeqi NP_001107804.1. NM_001114332.1. [Q3U9N9-1 ]
    NP_082523.1. NM_028247.4. [Q3U9N9-2 ]
    UniGenei Mm.186778.

    3D structure databases

    ProteinModelPortali Q3U9N9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi Q3U9N9.
    PaxDbi Q3U9N9.
    PRIDEi Q3U9N9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092566 ; ENSMUSP00000090227 ; ENSMUSG00000019838 . [Q3U9N9-1 ]
    GeneIDi 72472.
    KEGGi mmu:72472.
    UCSCi uc007ewm.2. mouse. [Q3U9N9-1 ]
    uc007ewn.2. mouse. [Q3U9N9-2 ]

    Organism-specific databases

    CTDi 117247.
    MGIi MGI:1919722. Slc16a10.

    Phylogenomic databases

    eggNOGi NOG321880.
    GeneTreei ENSGT00740000115479.
    HOGENOMi HOG000046644.
    HOVERGENi HBG006387.
    InParanoidi Q3U9N9.
    KOi K08187.
    OMAi HLMKHVN.
    OrthoDBi EOG7KWSH8.
    PhylomeDBi Q3U9N9.
    TreeFami TF313792.

    Miscellaneous databases

    NextBioi 336298.
    PROi Q3U9N9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3U9N9.
    Genevestigatori Q3U9N9.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow and Spleen.
    2. "Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway."
      Ramadan T., Camargo S.M., Summa V., Hunziker P., Chesnov S., Pos K.M., Verrey F.
      J. Cell. Physiol. 206:771-779(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, LACK OF GLYCOSYLATION.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495; SER-498 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOT10_MOUSE
    AccessioniPrimary (citable) accession number: Q3U9N9
    Secondary accession number(s): Q3TNJ1, Q3UAN9, Q8BWR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3