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Q3U9N9

- MOT10_MOUSE

UniProt

Q3U9N9 - MOT10_MOUSE

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Protein

Monocarboxylate transporter 10

Gene
Slc16a10, Mct10, Tat1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells.1 Publication

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:Slc16a10
Synonyms:Mct10, Tat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1919722. Slc16a10.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane
Note: Detected in basolateral membrane of kidney proximal tubule starting at he beginning of the proximal tubule epithelium within the glomerular capsule and extending to the S1 and S2 segments. Localizes also to the basolateral membrane of small intestine enterocytes and to sinusoidal side of perivenous hepatocytes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363Extracellular Reviewed predictionAdd
BLAST
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Topological domaini85 – 11127Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei112 – 13221Helical; Reviewed predictionAdd
BLAST
Topological domaini133 – 1419Extracellular Reviewed prediction
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Topological domaini163 – 1686Cytoplasmic Reviewed prediction
Transmembranei169 – 18921Helical; Reviewed predictionAdd
BLAST
Topological domaini190 – 20112Extracellular Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Reviewed predictionAdd
BLAST
Topological domaini223 – 23210Cytoplasmic Reviewed prediction
Transmembranei233 – 25321Helical; Reviewed predictionAdd
BLAST
Topological domaini254 – 29138Extracellular Reviewed predictionAdd
BLAST
Transmembranei292 – 31221Helical; Reviewed predictionAdd
BLAST
Topological domaini313 – 32614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei327 – 34721Helical; Reviewed predictionAdd
BLAST
Topological domaini348 – 36215Extracellular Reviewed predictionAdd
BLAST
Transmembranei363 – 38321Helical; Reviewed predictionAdd
BLAST
Topological domaini384 – 3841Cytoplasmic Reviewed prediction
Transmembranei385 – 40521Helical; Reviewed predictionAdd
BLAST
Topological domaini406 – 41611Extracellular Reviewed predictionAdd
BLAST
Transmembranei417 – 43721Helical; Reviewed predictionAdd
BLAST
Topological domaini438 – 44811Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei449 – 46921Helical; Reviewed predictionAdd
BLAST
Topological domaini470 – 51243Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Monocarboxylate transporter 10PRO_0000314254Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei495 – 4951Phosphoserine1 Publication
Modified residuei498 – 4981Phosphoserine1 Publication
Modified residuei501 – 5011Phosphoserine1 Publication

Post-translational modificationi

Not N-glycosylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3U9N9.
PaxDbiQ3U9N9.
PRIDEiQ3U9N9.

Expressioni

Tissue specificityi

Highly expressed in small intestine, particularly in jejunum and ileum, scarcely in colon and substantially in kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ3U9N9.
GenevestigatoriQ3U9N9.

Structurei

3D structure databases

ProteinModelPortaliQ3U9N9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321880.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ3U9N9.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG7KWSH8.
PhylomeDBiQ3U9N9.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3U9N9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPSQEEPAA ERETNEAQPP GPAPSDDAPL PGPGPSDVSD VAAEKVEVEL    50
TRSAGSEPPV PPEGGWGWLV MLAAMWCNGS VFGIQNAYGV LFVSMLDTFK 100
AKDDDNMAFK TAWVGSLSMG MIFFCCPIVS VFTDMFGCRR TAVVGAAVGF 150
IGLMSSSFVS SIEPLYLTYG IIFACGCSFA YQPSLVILGH YFKKRLGLVN 200
GIVTAGSSVF TILLPLLLGN LISSVKLFNT LRILCIFMFV LFLAGFTYRP 250
LVPSTKEKES GGSRSSFFSR RKLSPPKKVF NFALFKETTY AVWAAGIPLA 300
LFGYFVPYVH LMNHVKERFQ DVNNKEVLFM CIGITSGVGR LLFGRIADYL 350
PGVKKVYLQV LSFFFIGLMS MMIPLCSAFG ALIAVCLAMG LFDGCFISIM 400
APIAFELVGP QDASQAIGFL LGFMSIPMTV GPPIAGLLHD KLGTYDVAFY 450
LAGIPPFVGG VVLCLIPWIH SKKQRKISKN AGGEKMEKML ENQSSLLSGS 500
SGIFKKDSAS II 512
Length:512
Mass (Da):55,320
Last modified:October 11, 2005 - v1
Checksum:i4EF7A1400C8E0B04
GO
Isoform 2 (identifier: Q3U9N9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-320: MNHVKERFQ → VSMHLWLCL
     321-512: Missing.

Show »
Length:320
Mass (Da):34,718
Checksum:iA60696B0242BDF35
GO

Sequence cautioni

The sequence BAE38097.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 3209MNHVKERFQ → VSMHLWLCL in isoform 2. VSP_030252
Alternative sequencei321 – 512192Missing in isoform 2. VSP_030253Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111T → I in BAE30275. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050229 mRNA. Translation: BAC34135.1.
AK151290 mRNA. Translation: BAE30275.1.
AK151704 mRNA. Translation: BAE30627.1.
AK157355 mRNA. Translation: BAE34061.1.
AK165240 mRNA. Translation: BAE38097.1. Different initiation.
AK165579 mRNA. Translation: BAE38270.1.
CCDSiCCDS48543.1. [Q3U9N9-1]
RefSeqiNP_001107804.1. NM_001114332.1. [Q3U9N9-1]
NP_082523.1. NM_028247.4. [Q3U9N9-2]
UniGeneiMm.186778.

Genome annotation databases

EnsembliENSMUST00000092566; ENSMUSP00000090227; ENSMUSG00000019838. [Q3U9N9-1]
GeneIDi72472.
KEGGimmu:72472.
UCSCiuc007ewm.2. mouse. [Q3U9N9-1]
uc007ewn.2. mouse. [Q3U9N9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050229 mRNA. Translation: BAC34135.1 .
AK151290 mRNA. Translation: BAE30275.1 .
AK151704 mRNA. Translation: BAE30627.1 .
AK157355 mRNA. Translation: BAE34061.1 .
AK165240 mRNA. Translation: BAE38097.1 . Different initiation.
AK165579 mRNA. Translation: BAE38270.1 .
CCDSi CCDS48543.1. [Q3U9N9-1 ]
RefSeqi NP_001107804.1. NM_001114332.1. [Q3U9N9-1 ]
NP_082523.1. NM_028247.4. [Q3U9N9-2 ]
UniGenei Mm.186778.

3D structure databases

ProteinModelPortali Q3U9N9.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q3U9N9.
PaxDbi Q3U9N9.
PRIDEi Q3U9N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092566 ; ENSMUSP00000090227 ; ENSMUSG00000019838 . [Q3U9N9-1 ]
GeneIDi 72472.
KEGGi mmu:72472.
UCSCi uc007ewm.2. mouse. [Q3U9N9-1 ]
uc007ewn.2. mouse. [Q3U9N9-2 ]

Organism-specific databases

CTDi 117247.
MGIi MGI:1919722. Slc16a10.

Phylogenomic databases

eggNOGi NOG321880.
GeneTreei ENSGT00740000115479.
HOGENOMi HOG000046644.
HOVERGENi HBG006387.
InParanoidi Q3U9N9.
KOi K08187.
OMAi HLMKHVN.
OrthoDBi EOG7KWSH8.
PhylomeDBi Q3U9N9.
TreeFami TF313792.

Miscellaneous databases

NextBioi 336298.
PROi Q3U9N9.
SOURCEi Search...

Gene expression databases

Bgeei Q3U9N9.
Genevestigatori Q3U9N9.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow and Spleen.
  2. "Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway."
    Ramadan T., Camargo S.M., Summa V., Hunziker P., Chesnov S., Pos K.M., Verrey F.
    J. Cell. Physiol. 206:771-779(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION, LACK OF GLYCOSYLATION.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495; SER-498 AND SER-501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT10_MOUSE
AccessioniPrimary (citable) accession number: Q3U9N9
Secondary accession number(s): Q3TNJ1, Q3UAN9, Q8BWR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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