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Protein

Monocarboxylate transporter 10

Gene

Slc16a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:Slc16a10
Synonyms:Mct10, Tat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919722. Slc16a10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 512CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142541 – 512Monocarboxylate transporter 10Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1

Post-translational modificationi

Not N-glycosylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3U9N9.
PaxDbiQ3U9N9.
PeptideAtlasiQ3U9N9.
PRIDEiQ3U9N9.

PTM databases

iPTMnetiQ3U9N9.
PhosphoSitePlusiQ3U9N9.

Expressioni

Tissue specificityi

Highly expressed in small intestine, particularly in jejunum and ileum, scarcely in colon and substantially in kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000019838.
GenevisibleiQ3U9N9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090227.

Structurei

3D structure databases

ProteinModelPortaliQ3U9N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVX. Eukaryota.
ENOG410XRHC. LUCA.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ3U9N9.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG091G0449.
PhylomeDBiQ3U9N9.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U9N9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSQEEPAA ERETNEAQPP GPAPSDDAPL PGPGPSDVSD VAAEKVEVEL
60 70 80 90 100
TRSAGSEPPV PPEGGWGWLV MLAAMWCNGS VFGIQNAYGV LFVSMLDTFK
110 120 130 140 150
AKDDDNMAFK TAWVGSLSMG MIFFCCPIVS VFTDMFGCRR TAVVGAAVGF
160 170 180 190 200
IGLMSSSFVS SIEPLYLTYG IIFACGCSFA YQPSLVILGH YFKKRLGLVN
210 220 230 240 250
GIVTAGSSVF TILLPLLLGN LISSVKLFNT LRILCIFMFV LFLAGFTYRP
260 270 280 290 300
LVPSTKEKES GGSRSSFFSR RKLSPPKKVF NFALFKETTY AVWAAGIPLA
310 320 330 340 350
LFGYFVPYVH LMNHVKERFQ DVNNKEVLFM CIGITSGVGR LLFGRIADYL
360 370 380 390 400
PGVKKVYLQV LSFFFIGLMS MMIPLCSAFG ALIAVCLAMG LFDGCFISIM
410 420 430 440 450
APIAFELVGP QDASQAIGFL LGFMSIPMTV GPPIAGLLHD KLGTYDVAFY
460 470 480 490 500
LAGIPPFVGG VVLCLIPWIH SKKQRKISKN AGGEKMEKML ENQSSLLSGS
510
SGIFKKDSAS II
Length:512
Mass (Da):55,320
Last modified:October 11, 2005 - v1
Checksum:i4EF7A1400C8E0B04
GO
Isoform 2 (identifier: Q3U9N9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-320: MNHVKERFQ → VSMHLWLCL
     321-512: Missing.

Show »
Length:320
Mass (Da):34,718
Checksum:iA60696B0242BDF35
GO

Sequence cautioni

The sequence BAE38097 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211T → I in BAE30275 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030252312 – 320MNHVKERFQ → VSMHLWLCL in isoform 2. 1 Publication9
Alternative sequenceiVSP_030253321 – 512Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050229 mRNA. Translation: BAC34135.1.
AK151290 mRNA. Translation: BAE30275.1.
AK151704 mRNA. Translation: BAE30627.1.
AK157355 mRNA. Translation: BAE34061.1.
AK165240 mRNA. Translation: BAE38097.1. Different initiation.
AK165579 mRNA. Translation: BAE38270.1.
CCDSiCCDS48543.1. [Q3U9N9-1]
RefSeqiNP_001107804.1. NM_001114332.1. [Q3U9N9-1]
NP_082523.1. NM_028247.4. [Q3U9N9-2]
UniGeneiMm.186778.

Genome annotation databases

EnsembliENSMUST00000092566; ENSMUSP00000090227; ENSMUSG00000019838. [Q3U9N9-1]
GeneIDi72472.
KEGGimmu:72472.
UCSCiuc007ewm.2. mouse. [Q3U9N9-1]
uc007ewn.2. mouse. [Q3U9N9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050229 mRNA. Translation: BAC34135.1.
AK151290 mRNA. Translation: BAE30275.1.
AK151704 mRNA. Translation: BAE30627.1.
AK157355 mRNA. Translation: BAE34061.1.
AK165240 mRNA. Translation: BAE38097.1. Different initiation.
AK165579 mRNA. Translation: BAE38270.1.
CCDSiCCDS48543.1. [Q3U9N9-1]
RefSeqiNP_001107804.1. NM_001114332.1. [Q3U9N9-1]
NP_082523.1. NM_028247.4. [Q3U9N9-2]
UniGeneiMm.186778.

3D structure databases

ProteinModelPortaliQ3U9N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090227.

PTM databases

iPTMnetiQ3U9N9.
PhosphoSitePlusiQ3U9N9.

Proteomic databases

MaxQBiQ3U9N9.
PaxDbiQ3U9N9.
PeptideAtlasiQ3U9N9.
PRIDEiQ3U9N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092566; ENSMUSP00000090227; ENSMUSG00000019838. [Q3U9N9-1]
GeneIDi72472.
KEGGimmu:72472.
UCSCiuc007ewm.2. mouse. [Q3U9N9-1]
uc007ewn.2. mouse. [Q3U9N9-2]

Organism-specific databases

CTDi117247.
MGIiMGI:1919722. Slc16a10.

Phylogenomic databases

eggNOGiENOG410IMVX. Eukaryota.
ENOG410XRHC. LUCA.
GeneTreeiENSGT00740000115479.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ3U9N9.
KOiK08187.
OMAiHLMKHVN.
OrthoDBiEOG091G0449.
PhylomeDBiQ3U9N9.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc16a10. mouse.
PROiQ3U9N9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019838.
GenevisibleiQ3U9N9. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT10_MOUSE
AccessioniPrimary (citable) accession number: Q3U9N9
Secondary accession number(s): Q3TNJ1, Q3UAN9, Q8BWR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.