Vav1

Functionⁱ

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphotyrosine binding Source: Ensembl
Rac guanyl-nucleotide exchange factor activity Source: Ensembl

GO - Biological processⁱ

G-protein coupled receptor signaling pathway Source: Ensembl
immune response Source: Ensembl
integrin-mediated signaling pathway Source: Ensembl
neutrophil chemotaxis Source: Ensembl
phagocytosis Source: Ensembl
positive regulation of cell adhesion Source: Ensembl
positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
reactive oxygen species metabolic process Source: Ensembl
regulation of cell size Source: Ensembl
regulation of Rho protein signal transduction Source: InterPro
small GTPase mediated signal transduction Source: InterPro
T cell differentiation Source: Ensembl

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation
Ligand	Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported Submitted name: Vav 1 oncogeneImported
Gene namesⁱ	Name:Vav1Imported Synonyms:VavImported ORF Names:mCG_140673Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:98923. Vav1.

Subcellular locationⁱ

GO - Cellular componentⁱ

cell-cell junction Source: Ensembl
intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3U9E2.

MaxQBⁱ

Q3U9E2.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034116.
ExpressionAtlasⁱ	Q3U9E2. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

phosphotyrosine binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q3U9E2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 119	Actin-bindingInterPro annotationAdd BLAST	119
Domainⁱ	194 – 373	DH (DBL-homology)InterPro annotationAdd BLAST	180
Domainⁱ	402 – 504	PHInterPro annotationAdd BLAST	103
Domainⁱ	515 – 564	Phorbol-ester/DAG-typeInterPro annotationAdd BLAST	50
Domainⁱ	617 – 660	SH3InterPro annotationAdd BLAST	44
Domainⁱ	671 – 765	SH2InterPro annotationAdd BLAST	95
Domainⁱ	782 – 842	SH3InterPro annotationAdd BLAST	61

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotationSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG2996. Eukaryota. ENOG410XPH6. LUCA.
HOVERGENⁱ	HBG018066.
KEGG Orthology (KO) More...KOⁱ	K05730.
OMAⁱ	EKDNKKW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01O3.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000980. SH2. IPR001452. SH3_domain. IPR003096. SM22_calponin. IPR028530. Vav.
PANTHERⁱ	PTHR22826:SF178. PTHR22826:SF178. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 2 hits.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3U9E2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL 
        60         70         80         90        100
LPQAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF 
       110        120        130        140        150
DVQDFGKVIY TLSALSWTPI AQNKGIMPFP TEDSALNDED IYSGLSDQID 
       160        170        180        190        200
DTAEEDEDLY DCVENEEAEG DEIYEDLMRL ESVPTPPKMT EYDKRCCCLR 
       210        220        230        240        250
EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI EELFSVHTHF 
       260        270        280        290        300
LKELKDALAG PGATTLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA 
       310        320        330        340        350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA 
       360        370        380        390        400
TEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY 
       410        420        430        440        450
GRPKIDGELK ITSVERRSKT DRYAFLLDKA LLICKRRGDS YDLKASVNLH 
       460        470        480        490        500
SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE 
       510        520        530        540        550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCYRCR 
       560        570        580        590        600
APAHKECLGR VPPCGRHGQD FAGTMKKDKL HRRAQDKKRN ELGLPKMEVF 
       610        620        630        640        650
QEYYGIPPPP GAFGPFLRLN PGDIVELTKA EAEHNWWEGR NTATNEVGWF 
       660        670        680        690        700
PCNRVHPYVH GPPQDLSVHL WYAGPMERAG AEGILTNRSD GTYLVRQRVK 
       710        720        730        740        750
DTAEFAISIK YNVEVKHIKI MTSEGLYRIT EKKAFRGLLE LVEFYQQNSL 
       760        770        780        790        800
KDCFKSLDTT LQFPYKEPER RAISKPPAGS TKYFGTAKAR YDFCARDRSE 
       810        820        830        840 
LSLKEGDIIK ILNKKGQQGW WRGEIYGRIG WFPSNYVEED YSEYC

Length:845

Mass (Da):98,137

Last modified:October 11, 2005 - v1

Checksum:ⁱ3666DCCD1C5229DA

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902352 Genomic DNA. Translation: AAY21062.1. AK150398 mRNA. Translation: BAE29525.1. AK151831 mRNA. Translation: BAE30725.1. AK152555 mRNA. Translation: BAE31309.1. CH466537 Genomic DNA. Translation: EDL38258.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157287.1. NM_001163815.1. NP_035821.3. NM_011691.4.
UniGeneⁱ	Mm.248172.

Genome annotation databases

GeneIDⁱ	22324.
KEGGⁱ	mmu:22324.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY902352 Genomic DNA. Translation: AAY21062.1. AK150398 mRNA. Translation: BAE29525.1. AK151831 mRNA. Translation: BAE30725.1. AK152555 mRNA. Translation: BAE31309.1. CH466537 Genomic DNA. Translation: EDL38258.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157287.1. NM_001163815.1. NP_035821.3. NM_011691.4.
UniGeneⁱ	Mm.248172.

3D structure databases

SMRⁱ	Q3U9E2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3U9E2.

MaxQBⁱ

Q3U9E2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	22324.
KEGGⁱ	mmu:22324.

Organism-specific databases

CTDⁱ	7409.
MGIⁱ	MGI:98923. Vav1.

Phylogenomic databases

eggNOGⁱ	KOG2996. Eukaryota. ENOG410XPH6. LUCA.
HOVERGENⁱ	HBG018066.
KEGG Orthology (KO) More...KOⁱ	K05730.
OMAⁱ	EKDNKKW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01O3.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034116.
ExpressionAtlasⁱ	Q3U9E2. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000980. SH2. IPR001452. SH3_domain. IPR003096. SM22_calponin. IPR028530. Vav.
PANTHERⁱ	PTHR22826:SF178. PTHR22826:SF178. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 2 hits.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3U9E2_MOUSE
Accessionⁱ	Q3U9E2Primary (citable) accession number: Q3U9E2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q3U9E2 (Q3U9E2_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ