Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Derlin

Gene

Derl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DerlinUniRule annotation
Gene namesi
Name:Derl2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2151483. Derl2.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 59HelicalUniRule annotationAdd BLAST34
Transmembranei79 – 111HelicalUniRule annotationAdd BLAST33

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000018442.

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
GeneTreeiENSGT00530000063156.
HOVERGENiHBG051338.

Family and domain databases

InterProiView protein in InterPro
IPR007599. DER1.
IPR022764. Peptidase_S54_rhomboid_dom.
PANTHERiPTHR11009. PTHR11009. 1 hit.
SUPFAMiSSF144091. SSF144091. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3U957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFLYRYCRM LEEGSFRGRT ADFVFMFLFG GFLMTLFGLF VSLVFLGQAF
60 70 80 90 100
TIMLVYVWSR RNPYVRMNFF GLLNFQAPFL PWVLMGFSLL LGNSIIVDLL
110 120 130 140 150
GIAVGHIYFF LEDIFPNQPG GIRILKTPSI LRTIFDTPDE DPNYNPLPEE
160
RPGGFAWGEG QRLGG
Length:165
Mass (Da):18,933
Last modified:October 11, 2005 - v1
Checksum:i5471556969721EB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596136 Genomic DNA. No translation available.
AK151934 mRNA. Translation: BAE30810.1.
RefSeqiNP_001278075.1. NM_001291146.1.
NP_001278076.1. NM_001291147.1.
UniGeneiMm.28131.
Mm.446351.

Genome annotation databases

EnsembliENSMUST00000171041; ENSMUSP00000127568; ENSMUSG00000018442.
GeneIDi116891.
UCSCiuc056ymd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3U957_MOUSE
AccessioniPrimary (citable) accession number: Q3U957
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported