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Protein
Submitted name:

Putative uncharacterized protein

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytokine activity Source: MGI
  2. interleukin-10 receptor binding Source: GO_Central

GO - Biological processi

  1. branching involved in labyrinthine layer morphogenesis Source: MGI
  2. cellular response to lipopolysaccharide Source: MGI
  3. defense response to bacterium Source: MGI
  4. immune response Source: InterPro
  5. inflammatory response Source: MGI
  6. negative regulation of B cell proliferation Source: MGI
  7. negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
  8. negative regulation of cytokine secretion involved in immune response Source: MGI
  9. negative regulation of growth of symbiont in host Source: MGI
  10. negative regulation of inflammatory response Source: MGI
  11. negative regulation of interferon-gamma production Source: MGI
  12. negative regulation of interleukin-12 production Source: MGI
  13. negative regulation of interleukin-6 production Source: MGI
  14. negative regulation of membrane protein ectodomain proteolysis Source: MGI
  15. negative regulation of myeloid dendritic cell activation Source: MGI
  16. negative regulation of tumor necrosis factor production Source: MGI
  17. positive regulation of B cell apoptotic process Source: MGI
  18. positive regulation of cytokine secretion Source: MGI
  19. positive regulation of JAK-STAT cascade Source: GO_Central
  20. positive regulation of MHC class II biosynthetic process Source: MGI
  21. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  22. positive regulation of transcription, DNA-templated Source: MGI
  23. receptor biosynthetic process Source: MGI
  24. regulation of gene expression Source: MGI
  25. response to glucocorticoid Source: MGI
  26. response to molecule of bacterial origin Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Il10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96537. Il10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3U879.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016673.

Structurei

3D structure databases

ProteinModelPortaliQ3U879.
SMRiQ3U879. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004110.
KOiK05443.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U879-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ
60 70 80 90 100
VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK
110 120 130 140 150
HGPEIKEHLN SLSEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ
160 170
DQGVYKAMNE FDIFINCIEA YMMIKMKS
Length:178
Mass (Da):20,671
Last modified:October 11, 2005 - v1
Checksum:i9A35E3AFE144F12B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK152344 mRNA. Translation: BAE31139.1.
RefSeqiNP_034678.1. NM_010548.2.
UniGeneiMm.874.

Genome annotation databases

GeneIDi16153.
KEGGimmu:16153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK152344 mRNA. Translation: BAE31139.1.
RefSeqiNP_034678.1. NM_010548.2.
UniGeneiMm.874.

3D structure databases

ProteinModelPortaliQ3U879.
SMRiQ3U879. Positions 24-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16153.
KEGGimmu:16153.

Organism-specific databases

CTDi3586.
MGIiMGI:96537. Il10.

Phylogenomic databases

HOVERGENiHBG004110.
KOiK05443.

Miscellaneous databases

NextBioi288951.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3U879.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported.

Entry informationi

Entry nameiQ3U879_MOUSE
AccessioniPrimary (citable) accession number: Q3U879
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.