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Q3U879 (Q3U879_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Il10 MGI 96537
OrganismMus musculus (Mouse) EMBL BAE31139.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processbranching involved in labyrinthine layer morphogenesis

Inferred from mutant phenotype PubMed 12842419. Source: MGI

defense response to bacterium

Inferred from direct assay PubMed 10899905. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

negative regulation of B cell proliferation

Inferred from sequence orthology PubMed 9184696. Source: MGI

negative regulation of chronic inflammatory response to antigenic stimulus

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 18270204. Source: MGI

negative regulation of interferon-gamma production

Inferred from mutant phenotype PubMed 12452830. Source: MGI

negative regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 15240714. Source: MGI

negative regulation of myeloid dendritic cell activation

Inferred from mutant phenotype PubMed 15240714. Source: MGI

negative regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 12452830. Source: MGI

positive regulation of B cell apoptotic process

Inferred from sequence orthology PubMed 9184696. Source: MGI

positive regulation of MHC class II biosynthetic process

Inferred from direct assay PubMed 11027433. Source: MGI

regulation of gene expression

Inferred from sequence orthology PubMed 9184696. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 10545106PubMed 10899905PubMed 10940872PubMed 15220916PubMed 15240714PubMed 16275384PubMed 16949315PubMed 17137799PubMed 19139201PubMed 23892723. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 11027433. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3U879 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 9A35E3AFE144F12B

FASTA17820,671
        10         20         30         40         50         60 
MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 

        70         80         90        100        110        120 
LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLSEKLKTLR 

       130        140        150        160        170 
MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ DQGVYKAMNE FDIFINCIEA YMMIKMKS 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE31139.1.
Tissue: Bone marrow EMBL BAE31139.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK152344 mRNA. Translation: BAE31139.1.
RefSeqNP_034678.1. NM_010548.2.
UniGeneMm.874.

3D structure databases

ProteinModelPortalQ3U879.
SMRQ3U879. Positions 24-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000016673.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16153.
KEGGmmu:16153.

Organism-specific databases

CTD3586.
MGIMGI:96537. Il10.

Phylogenomic databases

HOVERGENHBG004110.
InParanoidQ3U879.
KOK05443.

Gene expression databases

GenevestigatorQ3U879.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERPTHR11585. PTHR11585. 1 hit.
PfamPF00726. IL10. 1 hit.
[Graphical view]
PRINTSPR01294. INTRLEUKIN10.
SMARTSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288951.
SOURCESearch...

Entry information

Entry nameQ3U879_MOUSE
AccessionPrimary (citable) accession number: Q3U879
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)