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Q3U879

- Q3U879_MOUSE

UniProt

Q3U879 - Q3U879_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Il10

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. branching involved in labyrinthine layer morphogenesis Source: MGI
    2. defense response to bacterium Source: MGI
    3. immune response Source: InterPro
    4. negative regulation of B cell proliferation Source: MGI
    5. negative regulation of chronic inflammatory response to antigenic stimulus Source: MGI
    6. negative regulation of growth of symbiont in host Source: MGI
    7. negative regulation of inflammatory response Source: MGI
    8. negative regulation of interferon-gamma production Source: MGI
    9. negative regulation of interleukin-12 production Source: MGI
    10. negative regulation of myeloid dendritic cell activation Source: MGI
    11. negative regulation of tumor necrosis factor production Source: MGI
    12. positive regulation of B cell apoptotic process Source: MGI
    13. positive regulation of MHC class II biosynthetic process Source: MGI
    14. regulation of gene expression Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Il10Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96537. Il10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3U879.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000016673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U879.
    SMRiQ3U879. Positions 24-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG004110.
    InParanoidiQ3U879.
    KOiK05443.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000098. IL-10.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    [Graphical view]
    PANTHERiPTHR11585. PTHR11585. 1 hit.
    PfamiPF00726. IL10. 1 hit.
    [Graphical view]
    PRINTSiPR01294. INTRLEUKIN10.
    SMARTiSM00188. IL10. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3U879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ    50
    VKTFFQTKDQ LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK 100
    HGPEIKEHLN SLSEKLKTLR MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ 150
    DQGVYKAMNE FDIFINCIEA YMMIKMKS 178
    Length:178
    Mass (Da):20,671
    Last modified:October 11, 2005 - v1
    Checksum:i9A35E3AFE144F12B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK152344 mRNA. Translation: BAE31139.1.
    RefSeqiNP_034678.1. NM_010548.2.
    UniGeneiMm.874.

    Genome annotation databases

    GeneIDi16153.
    KEGGimmu:16153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK152344 mRNA. Translation: BAE31139.1 .
    RefSeqi NP_034678.1. NM_010548.2.
    UniGenei Mm.874.

    3D structure databases

    ProteinModelPortali Q3U879.
    SMRi Q3U879. Positions 24-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000016673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16153.
    KEGGi mmu:16153.

    Organism-specific databases

    CTDi 3586.
    MGIi MGI:96537. Il10.

    Phylogenomic databases

    HOVERGENi HBG004110.
    InParanoidi Q3U879.
    KOi K05443.

    Miscellaneous databases

    NextBioi 288951.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3U879.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000098. IL-10.
    IPR020443. IL-10/19/20/24/26_fam.
    IPR020423. IL-10_CS.
    [Graphical view ]
    PANTHERi PTHR11585. PTHR11585. 1 hit.
    Pfami PF00726. IL10. 1 hit.
    [Graphical view ]
    PRINTSi PR01294. INTRLEUKIN10.
    SMARTi SM00188. IL10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Bone marrowImported.

    Entry informationi

    Entry nameiQ3U879_MOUSE
    AccessioniPrimary (citable) accession number: Q3U879
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)