Q3U879 (Q3U879_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE31139.1

Gene names

Name:

Il10 MGI 96537

Organism

Mus musculus (Mouse) EMBL BAE31139.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	branching involved in labyrinthine layer morphogenesis Inferred from mutant phenotype PubMed 12842419. Source: MGI defense response to bacterium Inferred from direct assay PubMed 10899905. Source: MGI immune response Inferred from electronic annotation. Source: InterPro negative regulation of B cell proliferation Inferred from sequence orthology PubMed 9184696. Source: MGI negative regulation of chronic inflammatory response to antigenic stimulus Inferred from mutant phenotype PubMed 12452830. Source: MGI negative regulation of growth of symbiont in host Inferred from mutant phenotype PubMed 12452830. Source: MGI negative regulation of interferon-gamma production Inferred from mutant phenotype PubMed 12452830. Source: MGI negative regulation of interleukin-12 production Inferred from mutant phenotype PubMed 15240714. Source: MGI negative regulation of myeloid dendritic cell activation Inferred from mutant phenotype PubMed 15240714. Source: MGI negative regulation of tumor necrosis factor production Inferred from mutant phenotype PubMed 12452830. Source: MGI positive regulation of B cell apoptotic process Inferred from sequence orthology PubMed 9184696. Source: MGI positive regulation of MHC class II biosynthetic process Inferred from direct assay PubMed 11027433. Source: MGI regulation of gene expression Inferred from sequence orthology PubMed 9184696. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 10545106PubMed 10899905PubMed 10940872PubMed 15220916PubMed 15240714PubMed 16275384PubMed 16949315PubMed 17137799PubMed 19139201. Source: MGI
Molecular_function	cytokine activity Inferred from direct assay PubMed 11027433. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3U879 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 9A35E3AFE144F12B	FASTA	178	20,671
	10 20 30 40 50 60 MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 70 80 90 100 110 120 LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLSEKLKTLR 130 140 150 160 170 MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ DQGVYKAMNE FDIFINCIEA YMMIKMKS

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE31139.1. Tissue: Bone marrow EMBL BAE31139.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK152344 mRNA. Translation: BAE31139.1.
IPI	IPI00654087.
RefSeq	NP_034678.1. NM_010548.2.
UniGene	Mm.874.
3D structure databases
ProteinModelPortal	Q3U879.
SMR	Q3U879. Positions 24-178.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000016673.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	16153.
KEGG	mmu:16153.
Organism-specific databases
CTD	3586.
MGI	MGI:96537. Il10.
Phylogenomic databases
HOVERGEN	HBG004110.
InParanoid	Q3U879.
KO	K05443.
Gene expression databases
Genevestigator	Q3U879.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR020443. Interleukin-10/19/20/24. IPR020423. Interleukin-10_CS. IPR000098. Interleukin_10. [Graphical view]
PANTHER	PTHR11585. PTHR11585. 1 hit.
Pfam	PF00726. IL10. 1 hit. [Graphical view]
PRINTS	PR01294. INTRLEUKIN10.
SMART	SM00188. IL10. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00520. INTERLEUKIN_10. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288951.
SOURCE	Search...

Entry information

Entry name

Q3U879_MOUSE

Accession

Primary (citable) accession number: Q3U879

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)