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Protein

AP-5 complex subunit zeta-1

Gene

Ap5z1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-5 complex subunit zeta-1
Alternative name(s):
Adaptor-related protein complex 5 zeta subunit
Short name:
Zeta5
Gene namesi
Name:Ap5z1
Synonyms:Kiaa0415
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924908 Ap5z1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002613581 – 807AP-5 complex subunit zeta-1Add BLAST807

Proteomic databases

EPDiQ3U829
MaxQBiQ3U829
PaxDbiQ3U829
PeptideAtlasiQ3U829
PRIDEiQ3U829

PTM databases

iPTMnetiQ3U829
PhosphoSitePlusiQ3U829

Expressioni

Gene expression databases

BgeeiENSMUSG00000039623
CleanExiMM_C330006K01RIK
ExpressionAtlasiQ3U829 baseline and differential
GenevisibleiQ3U829 MM

Interactioni

Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041863

Structurei

3D structure databases

ProteinModelPortaliQ3U829
SMRiQ3U829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi579 – 584Poly-Leu6

Phylogenomic databases

eggNOGiENOG410IH98 Eukaryota
ENOG410XQTJ LUCA
GeneTreeiENSGT00390000017592
HOGENOMiHOG000113147
HOVERGENiHBG061547
InParanoidiQ3U829
KOiK19025
OMAiPIAQFFL
OrthoDBiEOG091G01TS
PhylomeDBiQ3U829
TreeFamiTF331050

Family and domain databases

InterProiView protein in InterPro
IPR028222 AP5Z1
IPR016024 ARM-type_fold
PfamiView protein in Pfam
PF14764 SPG48, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

Q3U829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSAGAESLL HQAREIQDEE LRRFCSRVTK LLQEAPGPAT VDALQRLFLI
60 70 80 90 100
VSATKYPRRL EKMCVDLLQT TLCLPASPEQ LQVLCAAILR EMSPFNDLAL
110 120 130 140 150
SCDHTPNTRQ LSLVASVLLA QGDRKGEIRC VSQRIFKILE NRQPEGPSVR
160 170 180 190 200
PLLPILSKVI GLAPGILMED QTNLLSKRLV DWLRYASIQQ GLPYSGGFFS
210 220 230 240 250
TPRTRQPGPI TEVDGAVASD FFTVLSTGQH FTEDQWVNMQ AFSMLRKWLL
260 270 280 290 300
HSGPEDPCSP DADDKSELEG STLSVLSAAS TASRLLPPRE RLREVAFEYC
310 320 330 340 350
QRLLEQSNRR ALRKGDSDLQ KACLVEAVSV LDVLCRQDPS FLYRTLSCLK
360 370 380 390 400
ALHRRLGEDP GSERALVPLA QFFLNHGEAA AMDAEAVYGQ LLRGLPSERF
410 420 430 440 450
HSPTLAFEVI HFCTHNLALF DSHFLSLLRL SFPSLFKFLA WNSPPLTAEF
460 470 480 490 500
VVLLPALVDA GTAVEMLHAL LDLPCLTAAL DLQLRSTQTP SERLLWDISL
510 520 530 540 550
RVPSCLEAFQ DPQFQGLFRH LLRTKASGST ERLTPLHQVL KPMASCARVT
560 570 580 590 600
QCAEAVPVLL QAFFSAVTQT ADGALINQLA LLLLERSDSL YPVPQYEARV
610 620 630 640 650
HGVLSSQLLV LCKLKPSLVV ELSRELLEFV GSVSSIHSRA SVFTCVVWAI
660 670 680 690 700
GEYLSVTWDK RCTAEQINKF FEALEALLFE VTQSRPLADL PCCPPEVVTA
710 720 730 740 750
LMTTLTKLAS RSQDLIPRVS LFLSKMRTLA QNPATSSVHS EEGAESIRTR
760 770 780 790 800
ASELLTLLKM PSVAQFVFTP PAGVCQPRYH RDTNVALPLA LRTVSRLVEK

EAGLLPG
Length:807
Mass (Da):89,407
Last modified:October 11, 2005 - v1
Checksum:iDAFDB2B325A0FA40
GO

Sequence cautioni

The sequence BAC30747 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323C → G in AAH82786 (PubMed:15489334).Curated1
Sequence conflicti338D → N in BAC30747 (PubMed:16141072).Curated1
Sequence conflicti428L → I in BAE27165 (PubMed:16141072).Curated1
Sequence conflicti558V → I in BAC38605 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040924 mRNA Translation: BAC30747.1 Different initiation.
AK082759 mRNA Translation: BAC38605.1
AK146431 mRNA Translation: BAE27165.1
AK152402 mRNA Translation: BAE31190.1
BC082786 mRNA Translation: AAH82786.1
CCDSiCCDS39361.1
RefSeqiNP_766313.2, NM_172725.2
UniGeneiMm.78250

Genome annotation databases

EnsembliENSMUST00000038699; ENSMUSP00000041863; ENSMUSG00000039623
GeneIDi231855
KEGGimmu:231855
UCSCiuc009aiq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAP5Z1_MOUSE
AccessioniPrimary (citable) accession number: Q3U829
Secondary accession number(s): Q3UJJ0
, Q63ZW8, Q8BS06, Q8C488
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health