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Q3U6U5

- GTPB6_MOUSE

UniProt

Q3U6U5 - GTPB6_MOUSE

Protein

Putative GTP-binding protein 6

Gene

Gtpbp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Cofactori

    Magnesium.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi298 – 2981MagnesiumPROSITE-ProRule annotation
    Metal bindingi319 – 3191MagnesiumPROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative GTP-binding protein 6
    Gene namesi
    Name:Gtpbp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1306825. Gtpbp6.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Putative GTP-binding protein 6PRO_0000304799Add
    BLAST

    Proteomic databases

    PaxDbiQ3U6U5.
    PRIDEiQ3U6U5.

    PTM databases

    PhosphoSiteiQ3U6U5.

    Expressioni

    Gene expression databases

    BgeeiQ3U6U5.
    CleanExiMM_GTPBP6.
    GenevestigatoriQ3U6U5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U6U5.
    SMRiQ3U6U5. Positions 149-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 449165Hflx-type GPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation
    Contains 1 Hflx-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2262.
    GeneTreeiENSGT00390000001397.
    HOGENOMiHOG000260368.
    HOVERGENiHBG052970.
    InParanoidiQ3U6U5.
    OrthoDBiEOG7WHH9P.
    TreeFamiTF315022.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006073. GTP_binding_domain.
    IPR016496. GTPase_HflX.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10229. PTHR10229. 1 hit.
    PfamiPF01926. MMR_HSR1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
    PROSITEiPS51705. G_HFLX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3U6U5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFLRAAVLP GFWLPRVRRV QLVRSPAVTL PSPVRTVHAG SRVWGSAWAG    50
    GGPVRGGGEE DPREDEEEEE DELLRAPPLL PLDTQRVCVL HPDVKRPAGK 100
    KPRSTAEWQV AEAAALVRAL PGWSVASTLV VPSAAPGSRL VFGKGNFQDV 150
    TEKIKGCQDI TSVFLNVERM APPTKKELES AWGLRVFDRF TLVLHIFRCN 200
    ARTREARMQL ALAEIPLLRS SVNTDSGQQD QQGWGSRYIM GSGESPTELR 250
    ARALRDRELR LRRVLERLRD KRRLMRKERV RREFPVVSVV GYTNCGKTTL 300
    IQALTGEAAL QPRDQPFATL DVTVHAGLLP SRLRILYVDT IGFLSQLPHN 350
    LIHAFSATLE DVAYSDVLVH VTDVSHPDAE LQKATVLSTL RGLHLPPALL 400
    ESALEVHSKV DLVPGYTPPC SGALAVSAIS GRGLDELKAA LEASVLRATG 450
    RQVLTLCVRL GGPQLGWLYK EAVVQQVQEL PEGDAAHVTV VITQAAYGRF 500
    RKLFPIDAPS ALPH 514
    Length:514
    Mass (Da):56,475
    Last modified:October 11, 2005 - v1
    Checksum:i95774C6439C0B3E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti350 – 3501N → S in BAE26076. (PubMed:16141072)Curated
    Sequence conflicti350 – 3501N → S in BAE35103. (PubMed:16141072)Curated
    Sequence conflicti501 – 5011R → G in BAE35103. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144812 mRNA. Translation: BAE26076.1.
    AK152225 mRNA. Translation: BAE31052.1.
    AK152972 mRNA. Translation: BAE31629.1.
    AK159462 mRNA. Translation: BAE35103.1.
    CCDSiCCDS51604.1.
    RefSeqiNP_660129.2. NM_145147.5.
    UniGeneiMm.86267.

    Genome annotation databases

    EnsembliENSMUST00000077220; ENSMUSP00000076458; ENSMUSG00000033434.
    GeneIDi107999.
    KEGGimmu:107999.
    UCSCiuc008ypr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144812 mRNA. Translation: BAE26076.1 .
    AK152225 mRNA. Translation: BAE31052.1 .
    AK152972 mRNA. Translation: BAE31629.1 .
    AK159462 mRNA. Translation: BAE35103.1 .
    CCDSi CCDS51604.1.
    RefSeqi NP_660129.2. NM_145147.5.
    UniGenei Mm.86267.

    3D structure databases

    ProteinModelPortali Q3U6U5.
    SMRi Q3U6U5. Positions 149-438.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3U6U5.

    Proteomic databases

    PaxDbi Q3U6U5.
    PRIDEi Q3U6U5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077220 ; ENSMUSP00000076458 ; ENSMUSG00000033434 .
    GeneIDi 107999.
    KEGGi mmu:107999.
    UCSCi uc008ypr.2. mouse.

    Organism-specific databases

    CTDi 8225.
    MGIi MGI:1306825. Gtpbp6.

    Phylogenomic databases

    eggNOGi COG2262.
    GeneTreei ENSGT00390000001397.
    HOGENOMi HOG000260368.
    HOVERGENi HBG052970.
    InParanoidi Q3U6U5.
    OrthoDBi EOG7WHH9P.
    TreeFami TF315022.

    Miscellaneous databases

    NextBioi 359857.
    PROi Q3U6U5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3U6U5.
    CleanExi MM_GTPBP6.
    Genevestigatori Q3U6U5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006073. GTP_binding_domain.
    IPR016496. GTPase_HflX.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10229. PTHR10229. 1 hit.
    Pfami PF01926. MMR_HSR1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006809. GTP-binding_hflX_prd. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03156. GTP_HflX. 1 hit.
    PROSITEi PS51705. G_HFLX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Lung.

    Entry informationi

    Entry nameiGTPB6_MOUSE
    AccessioniPrimary (citable) accession number: Q3U6U5
    Secondary accession number(s): Q3TX13, Q3UMM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3