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Q3U6U5

- GTPB6_MOUSE

UniProt

Q3U6U5 - GTPB6_MOUSE

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Protein

Putative GTP-binding protein 6

Gene

Gtpbp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi298 – 2981MagnesiumPROSITE-ProRule annotation
Metal bindingi319 – 3191MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative GTP-binding protein 6
Gene namesi
Name:Gtpbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1306825. Gtpbp6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Putative GTP-binding protein 6PRO_0000304799Add
BLAST

Proteomic databases

MaxQBiQ3U6U5.
PaxDbiQ3U6U5.
PRIDEiQ3U6U5.

PTM databases

PhosphoSiteiQ3U6U5.

Expressioni

Gene expression databases

BgeeiQ3U6U5.
CleanExiMM_GTPBP6.
ExpressionAtlasiQ3U6U5. baseline.
GenevestigatoriQ3U6U5.

Structurei

3D structure databases

ProteinModelPortaliQ3U6U5.
SMRiQ3U6U5. Positions 149-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 449165Hflx-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation
Contains 1 Hflx-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2262.
GeneTreeiENSGT00390000001397.
HOGENOMiHOG000260368.
HOVERGENiHBG052970.
InParanoidiQ3U6U5.
OrthoDBiEOG7WHH9P.
TreeFamiTF315022.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U6U5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFLRAAVLP GFWLPRVRRV QLVRSPAVTL PSPVRTVHAG SRVWGSAWAG
60 70 80 90 100
GGPVRGGGEE DPREDEEEEE DELLRAPPLL PLDTQRVCVL HPDVKRPAGK
110 120 130 140 150
KPRSTAEWQV AEAAALVRAL PGWSVASTLV VPSAAPGSRL VFGKGNFQDV
160 170 180 190 200
TEKIKGCQDI TSVFLNVERM APPTKKELES AWGLRVFDRF TLVLHIFRCN
210 220 230 240 250
ARTREARMQL ALAEIPLLRS SVNTDSGQQD QQGWGSRYIM GSGESPTELR
260 270 280 290 300
ARALRDRELR LRRVLERLRD KRRLMRKERV RREFPVVSVV GYTNCGKTTL
310 320 330 340 350
IQALTGEAAL QPRDQPFATL DVTVHAGLLP SRLRILYVDT IGFLSQLPHN
360 370 380 390 400
LIHAFSATLE DVAYSDVLVH VTDVSHPDAE LQKATVLSTL RGLHLPPALL
410 420 430 440 450
ESALEVHSKV DLVPGYTPPC SGALAVSAIS GRGLDELKAA LEASVLRATG
460 470 480 490 500
RQVLTLCVRL GGPQLGWLYK EAVVQQVQEL PEGDAAHVTV VITQAAYGRF
510
RKLFPIDAPS ALPH
Length:514
Mass (Da):56,475
Last modified:October 11, 2005 - v1
Checksum:i95774C6439C0B3E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501N → S in BAE26076. (PubMed:16141072)Curated
Sequence conflicti350 – 3501N → S in BAE35103. (PubMed:16141072)Curated
Sequence conflicti501 – 5011R → G in BAE35103. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144812 mRNA. Translation: BAE26076.1.
AK152225 mRNA. Translation: BAE31052.1.
AK152972 mRNA. Translation: BAE31629.1.
AK159462 mRNA. Translation: BAE35103.1.
CCDSiCCDS51604.1.
RefSeqiNP_660129.2. NM_145147.5.
UniGeneiMm.86267.

Genome annotation databases

EnsembliENSMUST00000077220; ENSMUSP00000076458; ENSMUSG00000033434.
GeneIDi107999.
KEGGimmu:107999.
UCSCiuc008ypr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144812 mRNA. Translation: BAE26076.1 .
AK152225 mRNA. Translation: BAE31052.1 .
AK152972 mRNA. Translation: BAE31629.1 .
AK159462 mRNA. Translation: BAE35103.1 .
CCDSi CCDS51604.1.
RefSeqi NP_660129.2. NM_145147.5.
UniGenei Mm.86267.

3D structure databases

ProteinModelPortali Q3U6U5.
SMRi Q3U6U5. Positions 149-438.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3U6U5.

Proteomic databases

MaxQBi Q3U6U5.
PaxDbi Q3U6U5.
PRIDEi Q3U6U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077220 ; ENSMUSP00000076458 ; ENSMUSG00000033434 .
GeneIDi 107999.
KEGGi mmu:107999.
UCSCi uc008ypr.2. mouse.

Organism-specific databases

CTDi 8225.
MGIi MGI:1306825. Gtpbp6.

Phylogenomic databases

eggNOGi COG2262.
GeneTreei ENSGT00390000001397.
HOGENOMi HOG000260368.
HOVERGENi HBG052970.
InParanoidi Q3U6U5.
OrthoDBi EOG7WHH9P.
TreeFami TF315022.

Miscellaneous databases

NextBioi 359857.
PROi Q3U6U5.
SOURCEi Search...

Gene expression databases

Bgeei Q3U6U5.
CleanExi MM_GTPBP6.
ExpressionAtlasi Q3U6U5. baseline.
Genevestigatori Q3U6U5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10229. PTHR10229. 1 hit.
Pfami PF01926. MMR_HSR1. 1 hit.
[Graphical view ]
PIRSFi PIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03156. GTP_HflX. 1 hit.
PROSITEi PS51705. G_HFLX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Lung.

Entry informationi

Entry nameiGTPB6_MOUSE
AccessioniPrimary (citable) accession number: Q3U6U5
Secondary accession number(s): Q3TX13, Q3UMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3