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Protein

Putative GTP-binding protein 6

Gene

Gtpbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi298 – 2981MagnesiumPROSITE-ProRule annotation
Metal bindingi319 – 3191MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative GTP-binding protein 6
Gene namesi
Name:Gtpbp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1306825. Gtpbp6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Putative GTP-binding protein 6PRO_0000304799Add
BLAST

Proteomic databases

MaxQBiQ3U6U5.
PaxDbiQ3U6U5.
PRIDEiQ3U6U5.

PTM databases

PhosphoSiteiQ3U6U5.

Expressioni

Gene expression databases

BgeeiQ3U6U5.
CleanExiMM_GTPBP6.
ExpressionAtlasiQ3U6U5. baseline.
GenevestigatoriQ3U6U5.

Structurei

3D structure databases

ProteinModelPortaliQ3U6U5.
SMRiQ3U6U5. Positions 149-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 449165Hflx-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.PROSITE-ProRule annotation
Contains 1 Hflx-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2262.
GeneTreeiENSGT00390000001397.
HOGENOMiHOG000260368.
HOVERGENiHBG052970.
InParanoidiQ3U6U5.
OrthoDBiEOG7WHH9P.
TreeFamiTF315022.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030394. G_HFLX_dom.
IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U6U5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFLRAAVLP GFWLPRVRRV QLVRSPAVTL PSPVRTVHAG SRVWGSAWAG
60 70 80 90 100
GGPVRGGGEE DPREDEEEEE DELLRAPPLL PLDTQRVCVL HPDVKRPAGK
110 120 130 140 150
KPRSTAEWQV AEAAALVRAL PGWSVASTLV VPSAAPGSRL VFGKGNFQDV
160 170 180 190 200
TEKIKGCQDI TSVFLNVERM APPTKKELES AWGLRVFDRF TLVLHIFRCN
210 220 230 240 250
ARTREARMQL ALAEIPLLRS SVNTDSGQQD QQGWGSRYIM GSGESPTELR
260 270 280 290 300
ARALRDRELR LRRVLERLRD KRRLMRKERV RREFPVVSVV GYTNCGKTTL
310 320 330 340 350
IQALTGEAAL QPRDQPFATL DVTVHAGLLP SRLRILYVDT IGFLSQLPHN
360 370 380 390 400
LIHAFSATLE DVAYSDVLVH VTDVSHPDAE LQKATVLSTL RGLHLPPALL
410 420 430 440 450
ESALEVHSKV DLVPGYTPPC SGALAVSAIS GRGLDELKAA LEASVLRATG
460 470 480 490 500
RQVLTLCVRL GGPQLGWLYK EAVVQQVQEL PEGDAAHVTV VITQAAYGRF
510
RKLFPIDAPS ALPH
Length:514
Mass (Da):56,475
Last modified:October 11, 2005 - v1
Checksum:i95774C6439C0B3E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501N → S in BAE26076. (PubMed:16141072)Curated
Sequence conflicti350 – 3501N → S in BAE35103. (PubMed:16141072)Curated
Sequence conflicti501 – 5011R → G in BAE35103. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144812 mRNA. Translation: BAE26076.1.
AK152225 mRNA. Translation: BAE31052.1.
AK152972 mRNA. Translation: BAE31629.1.
AK159462 mRNA. Translation: BAE35103.1.
CCDSiCCDS51604.1.
RefSeqiNP_660129.2. NM_145147.5.
UniGeneiMm.86267.

Genome annotation databases

EnsembliENSMUST00000077220; ENSMUSP00000076458; ENSMUSG00000033434.
GeneIDi107999.
KEGGimmu:107999.
UCSCiuc008ypr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144812 mRNA. Translation: BAE26076.1.
AK152225 mRNA. Translation: BAE31052.1.
AK152972 mRNA. Translation: BAE31629.1.
AK159462 mRNA. Translation: BAE35103.1.
CCDSiCCDS51604.1.
RefSeqiNP_660129.2. NM_145147.5.
UniGeneiMm.86267.

3D structure databases

ProteinModelPortaliQ3U6U5.
SMRiQ3U6U5. Positions 149-438.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3U6U5.

Proteomic databases

MaxQBiQ3U6U5.
PaxDbiQ3U6U5.
PRIDEiQ3U6U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077220; ENSMUSP00000076458; ENSMUSG00000033434.
GeneIDi107999.
KEGGimmu:107999.
UCSCiuc008ypr.2. mouse.

Organism-specific databases

CTDi8225.
MGIiMGI:1306825. Gtpbp6.

Phylogenomic databases

eggNOGiCOG2262.
GeneTreeiENSGT00390000001397.
HOGENOMiHOG000260368.
HOVERGENiHBG052970.
InParanoidiQ3U6U5.
OrthoDBiEOG7WHH9P.
TreeFamiTF315022.

Miscellaneous databases

NextBioi359857.
PROiQ3U6U5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U6U5.
CleanExiMM_GTPBP6.
ExpressionAtlasiQ3U6U5. baseline.
GenevestigatoriQ3U6U5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030394. G_HFLX_dom.
IPR006073. GTP_binding_domain.
IPR016496. GTPase_HflX.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10229. PTHR10229. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PIRSFiPIRSF006809. GTP-binding_hflX_prd. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03156. GTP_HflX. 1 hit.
PROSITEiPS51705. G_HFLX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Lung.

Entry informationi

Entry nameiGTPB6_MOUSE
AccessioniPrimary (citable) accession number: Q3U6U5
Secondary accession number(s): Q3TX13, Q3UMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.