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Protein

Tyrosine-protein kinase

Gene

Lyn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LynImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96892. Lyn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000042228.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102SH3InterPro annotationAdd BLAST61
Domaini108 – 205SH2InterPro annotationAdd BLAST98
Domaini226 – 480Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG008761.

Family and domain databases

CDDicd10364. SH2_Src_Lyn. 1 hit.
cd12004. SH3_Lyn. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR035852. Lyn_SH2.
IPR035748. Lyn_SH3.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3U6Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKRKD NLNDDEVDSK TQPVPEFHLL PGQRFQTKDP EEQGDIVVAL
60 70 80 90 100
YPYDGIHPDD LSFKKGEKMK VLEEHGEWWK AKSLSSKREG FIPSNYVAKV
110 120 130 140 150
NTLETEEWFF KDITRKDAER QLLAPGNSAG AFLIRESETL KGSFSLSVRD
160 170 180 190 200
YDPMHGDVIK HYKIRSLDNG GYYISPRITF PCISDMIKHY QKQSDGLCRR
210 220 230 240 250
LEKACISPKP QKPWDKDAWE IPRESIKLVK KLGAGQFGEV WMGYYNNSTK
260 270 280 290 300
VAVKTLKPGT MSVQAFLEEA NLMKTLQHDK LVRLYAVVTK EEPIYIITEF
310 320 330 340 350
MAKGSLLDFL KSDEGGKVLL PKLIDFSAQI AEGMAYIERK NYIHRDLRAA
360 370 380 390 400
NVLVSESLMC KIADFGLARV IEDNEYTARE GAKFPIKWTA PEAINFGCFT
410 420 430 440 450
IKSDVWSFGI LLYEIVTYGK IPYPGRTNAD VMSALSQGYR MPRMENCPDE
460 470 480 490
LYDIMKMCWK EKAEERPTFD YLQSVLDDFY TATEGQYQQQ P
Length:491
Mass (Da):56,285
Last modified:October 11, 2005 - v1
Checksum:i2C82015D510B1F59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC157998 mRNA. Translation: AAI57999.1.
AK153038 mRNA. Translation: BAE31669.1.
RefSeqiNP_034877.2. NM_010747.2.
UniGeneiMm.317331.

Genome annotation databases

GeneIDi17096.
UCSCiuc008rwk.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3U6Q5_MOUSE
AccessioniPrimary (citable) accession number: Q3U6Q5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)