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Protein

Phosphoserine aminotransferase

Gene

Psat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (Phgdh)
  2. Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1)
  3. Phosphoserine phosphatase (Psph)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Serine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Gene namesi
Name:Psat1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2183441. Psat1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024640.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025542.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 354338Aminotran_5InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2790. Eukaryota.
COG1932. LUCA.
GeneTreeiENSGT00390000015177.
HOGENOMiHOG000088965.
HOVERGENiHBG001218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U6K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVAGSPWT SCPSCYLVLL EIQKQLLDYR GLGISVLEMS HRSSDFAKII
60 70 80 90 100
GNTENLVREL LAVPNNYKVI FVQGGGSGQF SAVPLNLIGL KAGRSADYVV
110 120 130 140 150
TGAWSAKAAE EAKKFGTVNI VHPKLGSYTK IPDPSTWNLN PDASYVYFCA
160 170 180 190 200
NETVHGVEFD FVPDVKGAVL VCDMSSNFLS RPVDVSKFGV IFAGAQKNVG
210 220 230 240 250
SAGVTVVIVR DDLLGFSLRE CPSVLDYKVQ AGNNSLYNTP PCFSIYVMGM
260 270 280 290 300
VLEWIKNNGG AAAMEKLSSI KSQMIYEIID NSQGFYVCPV ERQNRSRMNI
310 320 330 340 350
PFRIGNAKGD EALEKRFLDK AVELNMISLK GHRSVGGIRA SLYNAVTTED
360
VEKLAAFMKN FLEMHQL
Length:367
Mass (Da):40,176
Last modified:October 11, 2005 - v1
Checksum:i44429FD8A7BE44FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136453 Genomic DNA. No translation available.
AK152313 mRNA. Translation: BAE31118.1.
AK153093 mRNA. Translation: BAE31715.1.
RefSeqiNP_001192268.1. NM_001205339.1.
UniGeneiMm.289936.

Genome annotation databases

EnsembliENSMUST00000162053; ENSMUSP00000125340; ENSMUSG00000024640.
GeneIDi107272.
UCSCiuc008gwo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136453 Genomic DNA. No translation available.
AK152313 mRNA. Translation: BAE31118.1.
AK153093 mRNA. Translation: BAE31715.1.
RefSeqiNP_001192268.1. NM_001205339.1.
UniGeneiMm.289936.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025542.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162053; ENSMUSP00000125340; ENSMUSG00000024640.
GeneIDi107272.
UCSCiuc008gwo.2. mouse.

Organism-specific databases

CTDi29968.
MGIiMGI:2183441. Psat1.

Phylogenomic databases

eggNOGiKOG2790. Eukaryota.
COG1932. LUCA.
GeneTreeiENSGT00390000015177.
HOGENOMiHOG000088965.
HOVERGENiHBG001218.

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197.

Miscellaneous databases

ChiTaRSiPsat1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024640.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U6K9_MOUSE
AccessioniPrimary (citable) accession number: Q3U6K9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.