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Protein

Phosphoserine aminotransferase

Gene

Psat1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (Phgdh)
  2. Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1), Phosphoserine aminotransferase (Psat1)
  3. Phosphoserine phosphatase (Psph)
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotation, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
Gene namesi
Name:Psat1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2183441 Psat1

Expressioni

Gene expression databases

BgeeiENSMUSG00000024640

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 354Aminotran_5InterPro annotationAdd BLAST338

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2790 Eukaryota
COG1932 LUCA
GeneTreeiENSGT00390000015177
HOGENOMiHOG000088965
HOVERGENiHBG001218

Family and domain databases

CDDicd00611 PSAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00160 SerC_aminotrans_5, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR022278 Pser_aminoTfrase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000525 SerC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01364 serC_1, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q3U6K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVAGSPWT SCPSCYLVLL EIQKQLLDYR GLGISVLEMS HRSSDFAKII
60 70 80 90 100
GNTENLVREL LAVPNNYKVI FVQGGGSGQF SAVPLNLIGL KAGRSADYVV
110 120 130 140 150
TGAWSAKAAE EAKKFGTVNI VHPKLGSYTK IPDPSTWNLN PDASYVYFCA
160 170 180 190 200
NETVHGVEFD FVPDVKGAVL VCDMSSNFLS RPVDVSKFGV IFAGAQKNVG
210 220 230 240 250
SAGVTVVIVR DDLLGFSLRE CPSVLDYKVQ AGNNSLYNTP PCFSIYVMGM
260 270 280 290 300
VLEWIKNNGG AAAMEKLSSI KSQMIYEIID NSQGFYVCPV ERQNRSRMNI
310 320 330 340 350
PFRIGNAKGD EALEKRFLDK AVELNMISLK GHRSVGGIRA SLYNAVTTED
360
VEKLAAFMKN FLEMHQL
Length:367
Mass (Da):40,176
Last modified:October 11, 2005 - v1
Checksum:i44429FD8A7BE44FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136453 Genomic DNA No translation available.
AK152313 mRNA Translation: BAE31118.1
AK153093 mRNA Translation: BAE31715.1
RefSeqiNP_001192268.1, NM_001205339.1
UniGeneiMm.289936

Genome annotation databases

EnsembliENSMUST00000162053; ENSMUSP00000125340; ENSMUSG00000024640
GeneIDi107272
UCSCiuc008gwo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3U6K9_MOUSE
AccessioniPrimary (citable) accession number: Q3U6K9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health