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Protein
Submitted name:

Protein 2010002M12Rik

Gene

2010002M12Rik

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: MGI

GO - Biological processi

  1. cellular response to exogenous dsRNA Source: MGI
  2. cellular response to type I interferon Source: MGI
  3. intracellular transport of viral protein in host cell Source: MGI
  4. negative regulation of defense response to virus by host Source: MGI
  5. negative regulation of helicase activity Source: MGI
  6. negative regulation of protein binding Source: MGI
  7. negative regulation of viral genome replication Source: MGI
  8. positive regulation of viral genome replication Source: MGI
  9. response to virus Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_289225. ISG15 antiviral mechanism.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein 2010002M12RikImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:2010002M12RikImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2148249. 2010002M12Rik.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3U687.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093816.

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, TPR repeatUniRule annotation

Phylogenomic databases

eggNOGiNOG285705.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
OMAiCRANTND.
OrthoDBiEOG71K62V.
TreeFamiTF342671.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLLSPSNM SEESHKSHIH DSLDELRCHF TWELDIKDKH IHDLEIKISE
60 70 80 90 100
TEFRDPIYSI GMHNLLAYVR HLKGQQDEAL QSLKEAEALI QSEQLSKRSL
110 120 130 140 150
ATWGNCAWLH YHRGSLAEAQ VYLDKVEKVC KEFSSPFRYR LECAEMDCEE
160 170 180 190 200
GWALRKCGSQ NYTRAMACFE RALKVEPENP EYNAGYADVA YHLDYYDGNS
210 220 230 240 250
LQPLKKAVSV KPEDPYLKVL LALKLQDLRK TDEAEKHIKE ATLTISSQNN
260 270 280 290 300
IFGYVAKFYR RKGCVEEALG FLKKALETKP SSPYLHFQIG LCHKTQFFQM
310 320 330 340 350
KKATSRENRK RADQSCHLAI CHFKKTLELK PTYDRAYIDL AEVYAKNHQQ
360 370 380 390 400
KEAEDNFQEV LSMSNLGDYM QQEIHFRYGN FQQYYKKSEE AAITHYLKGL
410 420 430 440 450
KIEVTSHYRD KLLKALEELA EGRKEDHVLE SLSLLGLVCR LRGDTSEAMS
460
CYEKALRLTG AVNPEF
Length:466
Mass (Da):54,065
Last modified:October 11, 2005 - v1
Checksum:i5E260419AA33DC10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016791 Genomic DNA. No translation available.
BC138202 mRNA. Translation: AAI38203.1.
AK136525 mRNA. Translation: BAE23025.1.
AK153247 mRNA. Translation: BAE31838.1.
RefSeqiNP_444447.1. NM_053217.2.
UniGeneiMm.440727.

Genome annotation databases

EnsembliENSMUST00000087357; ENSMUSP00000093816; ENSMUSG00000067297.
ENSMUST00000112463; ENSMUSP00000108082; ENSMUSG00000067297.
GeneIDi112419.
KEGGimmu:112419.
UCSCiuc008hgs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016791 Genomic DNA. No translation available.
BC138202 mRNA. Translation: AAI38203.1.
AK136525 mRNA. Translation: BAE23025.1.
AK153247 mRNA. Translation: BAE31838.1.
RefSeqiNP_444447.1. NM_053217.2.
UniGeneiMm.440727.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093816.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087357; ENSMUSP00000093816; ENSMUSG00000067297.
ENSMUST00000112463; ENSMUSP00000108082; ENSMUSG00000067297.
GeneIDi112419.
KEGGimmu:112419.
UCSCiuc008hgs.1. mouse.

Organism-specific databases

MGIiMGI:2148249. 2010002M12Rik.

Phylogenomic databases

eggNOGiNOG285705.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
OMAiCRANTND.
OrthoDBiEOG71K62V.
TreeFamiTF342671.

Enzyme and pathway databases

ReactomeiREACT_289225. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi367915.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3U687.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Bone marrowImported and CecumImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3U687_MOUSE
AccessioniPrimary (citable) accession number: Q3U687
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.