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Q3U5Q7

- CMPK2_MOUSE

UniProt

Q3U5Q7 - CMPK2_MOUSE

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Protein

UMP-CMP kinase 2, mitochondrial

Gene
Cmpk2, Tyki
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity By similarity.

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi259 – 2668ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cytidylate kinase activity Source: MGI
  3. nucleoside diphosphate kinase activity Source: UniProtKB
  4. thymidylate kinase activity Source: Ensembl
  5. UMP kinase activity Source: MGI

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: MGI
  2. dTDP biosynthetic process Source: Ensembl
  3. dUDP biosynthetic process Source: Ensembl
  4. nucleoside diphosphate phosphorylation Source: UniProtKB
  5. nucleoside triphosphate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UMP-CMP kinase 2, mitochondrial (EC:2.7.4.14)
Alternative name(s):
Nucleoside-diphosphate kinase (EC:2.7.4.6)
Thymidylate kinase LPS-inducible member
Short name:
TYKi
Gene namesi
Name:Cmpk2
Synonyms:Tyki
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:99830. Cmpk2.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7373Mitochondrion Reviewed predictionAdd
BLAST
Chaini74 – 447374UMP-CMP kinase 2, mitochondrialPRO_0000331525Add
BLAST

Proteomic databases

MaxQBiQ3U5Q7.
PaxDbiQ3U5Q7.
PRIDEiQ3U5Q7.

Expressioni

Inductioni

By lipopolysaccharides in macrophages and in primary microglia.2 Publications

Gene expression databases

BgeeiQ3U5Q7.
GenevestigatoriQ3U5Q7.

Structurei

3D structure databases

ProteinModelPortaliQ3U5Q7.
SMRiQ3U5Q7. Positions 248-445.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili380 – 41233 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiNOG259135.
GeneTreeiENSGT00640000091577.
HOGENOMiHOG000082499.
HOVERGENiHBG088202.
InParanoidiQ3U5Q7.
KOiK13809.
OMAiHPVYQWP.
OrthoDBiEOG73NG3S.
PhylomeDBiQ3U5Q7.
TreeFamiTF328875.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR014505. UMP-CMP_kinase_mit.
[Graphical view]
PIRSFiPIRSF019736. dTMP_TKRP1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U5Q7-1 [UniParc]FASTAAdd to Basket

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MALISRPRAP LWLGRLSRRL CGRHQACMGT MARPRRFTVE LPDCSLTHFV    50
LGDATDHRDA RLAELLGPPG RSYALCVPLA PGEGCGPRVQ AARVHHRLLQ 100
QLRRGPLQRC QLSKLLGYGP GDQAGEAQHG FLLRDPCDHP DTRRDLLQLL 150
GSCQEAARPQ LAEFQADSQG LLWQRLWELQ GDRQVQVDCA CVLPAQEPHL 200
HPLLPDLLNS AVFQDRDAAR AVLEECTSFI PEARAVLDLV DQCPKEVQKG 250
KFQVIAIEGL DATGKTTLTQ SVSESLKAVL LQSPPPCISQ WRKIFDDEPT 300
IIRRAFYSLG NYLVASEIAK ESTNFPVIVD RYWHSTATYA IATEVSGGLQ 350
YLPPAHHPVY QWPGDLLKPD LVLLLTVNSE ERVRRLQGRG QEKTKEEAEL 400
EANNVFRQKV EMTYQRMENP SCHLVDASPS RETVLQKVLE LIQSSGR 447
Length:447
Mass (Da):50,036
Last modified:April 29, 2008 - v2
Checksum:i37CBACA251A40CFC
GO

Sequence cautioni

The sequence AAA58770.1 differs from that shown. Reason: Sequence differs due to frameshifts, sequencing errors and other discrepancies.
The sequence BAB23396.1 differs from that shown. Reason: Frameshift at position 74.
The sequence AAH27329.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH57565.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE29625.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE29646.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE29803.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE29932.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE31987.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141G → R in BAE29625. 1 Publication
Sequence conflicti183 – 1831R → K in BAE32020. 1 Publication
Sequence conflicti225 – 2251E → G in BAE32020. 1 Publication
Sequence conflicti317 – 3171E → G in BAE29625. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004595 mRNA. Translation: BAB23396.1. Frameshift.
AK153469 mRNA. Translation: BAE32020.1.
AK150512 mRNA. Translation: BAE29625.1. Different initiation.
AK150543 mRNA. Translation: BAE29646.1. Different initiation.
AK150725 mRNA. Translation: BAE29803.1. Different initiation.
AK150885 mRNA. Translation: BAE29932.1. Different initiation.
AK153429 mRNA. Translation: BAE31987.1. Different initiation.
BC027329 mRNA. Translation: AAH27329.1. Different initiation.
BC057565 mRNA. Translation: AAH57565.1. Different initiation.
L32973 mRNA. Translation: AAA58770.1. Sequence problems.
CCDSiCCDS49039.1.
RefSeqiNP_065582.3. NM_020557.4.
UniGeneiMm.271839.

Genome annotation databases

EnsembliENSMUST00000020969; ENSMUSP00000020969; ENSMUSG00000020638.
GeneIDi22169.
KEGGimmu:22169.
UCSCiuc007nfj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004595 mRNA. Translation: BAB23396.1 . Frameshift.
AK153469 mRNA. Translation: BAE32020.1 .
AK150512 mRNA. Translation: BAE29625.1 . Different initiation.
AK150543 mRNA. Translation: BAE29646.1 . Different initiation.
AK150725 mRNA. Translation: BAE29803.1 . Different initiation.
AK150885 mRNA. Translation: BAE29932.1 . Different initiation.
AK153429 mRNA. Translation: BAE31987.1 . Different initiation.
BC027329 mRNA. Translation: AAH27329.1 . Different initiation.
BC057565 mRNA. Translation: AAH57565.1 . Different initiation.
L32973 mRNA. Translation: AAA58770.1 . Sequence problems.
CCDSi CCDS49039.1.
RefSeqi NP_065582.3. NM_020557.4.
UniGenei Mm.271839.

3D structure databases

ProteinModelPortali Q3U5Q7.
SMRi Q3U5Q7. Positions 248-445.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q3U5Q7.
PaxDbi Q3U5Q7.
PRIDEi Q3U5Q7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020969 ; ENSMUSP00000020969 ; ENSMUSG00000020638 .
GeneIDi 22169.
KEGGi mmu:22169.
UCSCi uc007nfj.1. mouse.

Organism-specific databases

CTDi 129607.
MGIi MGI:99830. Cmpk2.

Phylogenomic databases

eggNOGi NOG259135.
GeneTreei ENSGT00640000091577.
HOGENOMi HOG000082499.
HOVERGENi HBG088202.
InParanoidi Q3U5Q7.
KOi K13809.
OMAi HPVYQWP.
OrthoDBi EOG73NG3S.
PhylomeDBi Q3U5Q7.
TreeFami TF328875.

Miscellaneous databases

NextBioi 302112.
PROi Q3U5Q7.
SOURCEi Search...

Gene expression databases

Bgeei Q3U5Q7.
Genevestigatori Q3U5Q7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR014505. UMP-CMP_kinase_mit.
[Graphical view ]
PIRSFi PIRSF019736. dTMP_TKRP1. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and Czech II.
    Tissue: Mammary tumor.
  3. "A unique member of the thymidylate kinase family that is induced during macrophage activation."
    Lee C.G.L., O'Brien W.E.
    J. Immunol. 154:6094-6102(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: BALB/c.
  4. "The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions."
    Lund S., Christensen K.V., Hedtjarn M., Mortensen A.L., Hagberg H., Falsig J., Hasseldam H., Schrattenholz A., Poerzgen P., Leist M.
    J. Neuroimmunol. 180:71-87(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCMPK2_MOUSE
AccessioniPrimary (citable) accession number: Q3U5Q7
Secondary accession number(s): Q3UCI7
, Q5XKG5, Q62316, Q6PFG7, Q9DC34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi