Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Growth factor receptor bound protein 2, isoform CRA_b

Gene

Grb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Growth factor receptor bound protein 2, isoform CRA_bImported
Gene namesi
Name:Grb2Imported
ORF Names:mCG_6612Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95805. Grb2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000059923.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58SH3InterPro annotationAdd BLAST58
Domaini60 – 152SH2InterPro annotationAdd BLAST93
Domaini156 – 215SH3InterPro annotationAdd BLAST60

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
HOVERGENiHBG005404.
KOiK04364.
OMAiHWWHGEI.
OrthoDBiEOG091G0HWS.

Family and domain databases

CDDicd11949. SH3_GRB2_C. 1 hit.
cd11946. SH3_GRB2_N. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR030219. Grb2.
IPR035643. GRB2_C_SH3.
IPR035641. GRB2_N_SH3.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom.
IPR001452. SH3_domain.
PANTHERiPTHR24418:SF290. PTHR24418:SF290. 1 hit.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3U5I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,238
Last modified:October 11, 2005 - v1
Checksum:i97F4A4FE4B248DDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148148 mRNA. Translation: BAE28376.1.
AK153557 mRNA. Translation: BAE32093.1.
AK166142 mRNA. Translation: BAE38595.1.
AK170845 mRNA. Translation: BAE42068.1.
CH466558 Genomic DNA. Translation: EDL34516.1.
CH466558 Genomic DNA. Translation: EDL34517.1.
RefSeqiNP_001300865.1. NM_001313936.1.
NP_001300866.1. NM_001313937.1.
NP_032189.1. NM_008163.4.
UniGeneiMm.439649.
Mm.490413.

Genome annotation databases

GeneIDi14784.
KEGGimmu:14784.

Similar proteinsi

Entry informationi

Entry nameiQ3U5I5_MOUSE
AccessioniPrimary (citable) accession number: Q3U5I5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)