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Protein
Submitted name:

Growth factor receptor bound protein 2, isoform CRA_b

Gene

Grb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Growth factor receptor bound protein 2, isoform CRA_bImported
Gene namesi
Name:Grb2Imported
ORF Names:mCG_6612Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95805. Grb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000059923.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021090.

Structurei

3D structure databases

SMRiQ3U5I5. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5858SH3InterPro annotationAdd
BLAST
Domaini60 – 15293SH2InterPro annotationAdd
BLAST
Domaini156 – 21560SH3InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 SH3 domains.UniRule annotation
Contains SH2 domain.SAAS annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
HOVERGENiHBG005404.
KOiK04364.
OMAiYDFTPQE.
OrthoDBiEOG091G0HWS.
PhylomeDBiQ3U5I5.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U5I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,238
Last modified:October 11, 2005 - v1
Checksum:i97F4A4FE4B248DDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148148 mRNA. Translation: BAE28376.1.
AK153557 mRNA. Translation: BAE32093.1.
AK166142 mRNA. Translation: BAE38595.1.
AK170845 mRNA. Translation: BAE42068.1.
CH466558 Genomic DNA. Translation: EDL34516.1.
CH466558 Genomic DNA. Translation: EDL34517.1.
RefSeqiNP_001300865.1. NM_001313936.1.
NP_001300866.1. NM_001313937.1.
NP_032189.1. NM_008163.4.
UniGeneiMm.439649.
Mm.490413.

Genome annotation databases

GeneIDi14784.
KEGGimmu:14784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148148 mRNA. Translation: BAE28376.1.
AK153557 mRNA. Translation: BAE32093.1.
AK166142 mRNA. Translation: BAE38595.1.
AK170845 mRNA. Translation: BAE42068.1.
CH466558 Genomic DNA. Translation: EDL34516.1.
CH466558 Genomic DNA. Translation: EDL34517.1.
RefSeqiNP_001300865.1. NM_001313936.1.
NP_001300866.1. NM_001313937.1.
NP_032189.1. NM_008163.4.
UniGeneiMm.439649.
Mm.490413.

3D structure databases

SMRiQ3U5I5. Positions 1-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14784.
KEGGimmu:14784.

Organism-specific databases

CTDi2885.
MGIiMGI:95805. Grb2.

Phylogenomic databases

eggNOGiKOG3601. Eukaryota.
ENOG410XR1G. LUCA.
HOVERGENiHBG005404.
KOiK04364.
OMAiYDFTPQE.
OrthoDBiEOG091G0HWS.
PhylomeDBiQ3U5I5.

Miscellaneous databases

ChiTaRSiGrb2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059923.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U5I5_MOUSE
AccessioniPrimary (citable) accession number: Q3U5I5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.