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Unreviewed, UniProtKB/TrEMBL Q3U5G1 (Q3U5G1_MOUSE)

Last modified February 9, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAE32118.1
Gene names
Name: Itk MGI 96621
OrganismMus musculus (Mouse) EMBL BAE32118.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Spearmint SPM020635

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 PH domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Contains 1 protein kinase domain.

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Sequences

Sequence LengthMass (Da)Tools
Q3U5G1-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 77BDD985078C354B

FASTA62271,888
        10         20         30         40         50         60 
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 

        70         80         90        100        110        120 
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ RWVLTLKEKT RNNNSLVSKY 

       130        140        150        160        170        180 
HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK NASKKPLPPT PEDNRVSERS FQEPEETLVI 

       190        200        210        220        230        240 
ALYDYQTNDP QELALRCDEE YYLLDSSEIH WWRVQDKNGH EGYAPSSYLV EKSPNNLETY 

       250        260        270        280        290        300 
EWYNKSISRD KAEKLLLDTG KEGAFMVRDS RTPGTYTVSV FTKAIISENP CIKHYHIKET 

       310        320        330        340        350        360 
NDSPKRYYVA EKYVFDSIPL LIQYHQYNGG GLVTRLRYPV CSWRQKAPVT AGLRYGKWVI 

       370        380        390        400        410        420 
QPSELTFVQE IGSGQFGLVH LGYWLNKDKV AIKTIQEGAM SEEDFIEEAE VMMKLSHPKL 

       430        440        450        460        470        480 
VQLYGVCLEQ APICLVFEFM EHGCLSDYLR SQRGLFAAET LLGMCLDVCE GMAYLEKACV 

       490        500        510        520        530        540 
IHRDLAARNC LVGENQVIKV SDFGMTRFVL DDQYTSSTGT KFPVKWASPE VFSFSRYSSK 

       550        560        570        580        590        600 
SDVWSFGVLM WEVFSEGKIP YENRSNSEVV EDISTGFRLY KPRLASCHVY QIMNHCWKEK 

       610        620 
PEDRPPFSQL LSQLAEIAEA GL

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE32118.1.
Tissue: Thymus EMBL BAE32118.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK153613 mRNA. Translation: BAE32118.1.
IPIIPI00133425.
UniGeneMm.339927

3D structure databases

SMRQ3U5G1. Positions 5-146, 116-165, 154-233, 235-341, 359-621.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3U5G1.

Genome annotation databases

EnsemblENSMUST00000109237; ENSMUSP00000104860; ENSMUSG00000020395; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:96621. Itk.

Phylogenomic databases

HOVERGENQ3U5G1.

Gene expression databases

ArrayExpressQ3U5G1.
BgeeQ3U5G1.
GenevestigatorQ3U5G1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR001562. Znf_Btk_motif.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 1 hit.
G3DSA:3.30.505.10. SH2. 1 hit.
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00779. BTK. 1 hit.
PF00169. PH. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ3U5G1_MOUSE
AccessionPrimary (citable) accession number: Q3U5G1
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information