Reviewed, UniProtKB/Swiss-Prot Q3U5C7 (PRIC1_MOUSE)

Names and origin

Protein names

Recommended name:
    Prickle-like protein 1

Gene names

Name:

Prickle1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	832 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Necessary for nuclear localization of REST. May serve as nuclear receptor By similarity.
Subunit structure	Interacts with REST By similarity.
Subcellular location	Nucleus membrane By similarity. Cytoplasm › cytosol By similarity. Note: A smaller amount is detected in the cytosol By similarity.
Sequence similarities	Belongs to the prickle / espinas / testin family. Contains 3 LIM zinc-binding domains. Contains 1 PET domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Lipoprotein Phosphoprotein Prenylation
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 832	832	Prickle-like protein 1		PRO_0000283027
Regions
	Domain	14 – 122	109	PET
	Domain	124 – 188	65	LIM zinc-binding 1
	Domain	189 – 249	61	LIM zinc-binding 2
	Domain	250 – 313	64	LIM zinc-binding 3
	Compositional bias	817 – 822	6	Poly-Lys
Amino acid modifications
	Modified residue	682	1	Phosphoserine Ref.3
	Lipidation	829	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3U5C7-1 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 8E664AAEA2E23CEA	FASTA	832	94,131
	10 20 30 40 50 60 MPLEMEPKMS KLVFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 70 80 90 100 110 120 NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 130 140 150 160 170 180 VMHAVCEQCG LQMNGGEVAV FASRAGPGVC WHPSCFVCFT CNELLVDLIY FYQDGKIHCG 190 200 210 220 230 240 RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 250 260 270 280 290 300 GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 310 320 330 340 350 360 YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF 370 380 390 400 410 420 PGLSGNADDT LSRKLDDVSL ASRQGAGFAN EEFWKARVEQ EASEDPEEWA EHEDYMTQLL 430 440 450 460 470 480 LKFGDKNLFQ QQSSEVDPRA SEHWIPDNMV TNKPEVKPNH QGLASKKYQS DMYWAQSQDG 490 500 510 520 530 540 LGDSAYGSHP GPASSRRLQE LDLDHGAAGY THDQSQWYED SLECLSDLKP EQSIRDSMDS 550 560 570 580 590 600 LALSNITGAS VDGESKPRPS LYSLQNFEEI EAEDCEKMSN MGTLNSSMLH RSAESLQSLN 610 620 630 640 650 660 SGLCPEKILP EEKPAHLPVL RRSKSQSRPQ QVKFSDDVID NGSYDIEIRQ PPMSERTRRR 670 680 690 700 710 720 AYHFEERGSR PHHHRHRRSR KSRSDNALNL VTERKYSAKD RLRLYTPDNY EKFIQNKSAR 730 740 750 760 770 780 ELQAYMQNAN LYSQYAHATS DYALQNPGMN RFLGLCGEDD DSWCSSSTSS SDSEEEGYFL 790 800 810 820 830 GQPIPQPRPQ RFTYYTDDLS SPASALPTPQ FTQRTTKSKK KKGHKGKNCI IS

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Thymus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK153711 mRNA. Translation: BAE32152.1. BC117892 mRNA. Translation: AAI17893.1. BC117893 mRNA. Translation: AAI17894.1.
IPI	IPI00406465.
RefSeq	NP_001028389.1.
UniGene	Mm.476820
3D structure databases
SMR	Q3U5C7. Positions 124-262.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3U5C7.
PTM databases
PhosphoSite	Q3U5C7.
Proteomic databases
PRIDE	Q3U5C7.
Genome annotation databases
Ensembl	ENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158; Mus musculus. [Genome view] ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158; Mus musculus. [Genome view]
GeneID	106042.
KEGG	mmu:106042.
UCSC	uc007xja.1. mouse.
Organism-specific databases
CTD	106042.
MGI	MGI:1916034. Prickle1.
Phylogenomic databases
eggNOG	roNOG13089.
HOGENOM	HBG447030.
HOVERGEN	Q3U5C7.
InParanoid	Q3U5C7.
OMA	CCLECET.
OrthoDB	EOG9NP9NT.
Gene expression databases
ArrayExpress	Q3U5C7.
Bgee	Q3U5C7.
CleanEx	MM_PRICKLE1.
Genevestigator	Q3U5C7.
Family and domain databases
InterPro	IPR010442. PET_domain. IPR001781. Znf_LIM. [Graphical view]
Gene3D	G3DSA:2.10.110.10. Znf_LIM. 2 hits.
Pfam	PF00412. LIM. 3 hits. PF06297. PET. 1 hit. [Graphical view]
SMART	SM00132. LIM. 3 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 3 hits. PS51303. PET. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	358030.
SOURCE	Search...

Entry information

Entry name

PRIC1_MOUSE

Accession

Primary (citable) accession number: Q3U5C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 11, 2005
Last modified:	January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)