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Reviewed, UniProtKB/Swiss-Prot Q3U5C7 (PRIC1_MOUSE)

Last modified January 19, 2010. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Prickle-like protein 1
Gene names
Name: Prickle1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Necessary for nuclear localization of REST. May serve as nuclear receptor By similarity.

Subunit structure

Interacts with REST By similarity.

Subcellular location

Nucleus membrane By similarity. Cytoplasm › cytosol By similarity. Note: A smaller amount is detected in the cytosol By similarity.

Sequence similarities

Belongs to the prickle / espinas / testin family.

Contains 3 LIM zinc-binding domains.

Contains 1 PET domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
Nucleus
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   PTMLipoprotein
Phosphoprotein
Prenylation
Gene Ontology (GO)
   Cellular componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Prickle-like protein 1
PRO_0000283027

Regions

Domain14 – 122109PET
Domain124 – 18865LIM zinc-binding 1
Domain189 – 24961LIM zinc-binding 2
Domain250 – 31364LIM zinc-binding 3
Compositional bias817 – 8226Poly-Lys

Amino acid modifications

Modified residue6821Phosphoserine Ref.3
Lipidation8291S-farnesyl cysteine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3U5C7-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 8E664AAEA2E23CEA

FASTA83294,131
        10         20         30         40         50         60 
MPLEMEPKMS KLVFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA CLPEEKVPYV 

        70         80         90        100        110        120 
NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF SAQRKKEALG RGTIKLLSRA 

       130        140        150        160        170        180 
VMHAVCEQCG LQMNGGEVAV FASRAGPGVC WHPSCFVCFT CNELLVDLIY FYQDGKIHCG 

       190        200        210        220        230        240 
RHHAELLKPR CSACDEIIFA DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC 

       250        260        270        280        290        300 
GCFESLYAEY CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI 

       310        320        330        340        350        360 
YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL LLSPALNYKF 

       370        380        390        400        410        420 
PGLSGNADDT LSRKLDDVSL ASRQGAGFAN EEFWKARVEQ EASEDPEEWA EHEDYMTQLL 

       430        440        450        460        470        480 
LKFGDKNLFQ QQSSEVDPRA SEHWIPDNMV TNKPEVKPNH QGLASKKYQS DMYWAQSQDG 

       490        500        510        520        530        540 
LGDSAYGSHP GPASSRRLQE LDLDHGAAGY THDQSQWYED SLECLSDLKP EQSIRDSMDS 

       550        560        570        580        590        600 
LALSNITGAS VDGESKPRPS LYSLQNFEEI EAEDCEKMSN MGTLNSSMLH RSAESLQSLN 

       610        620        630        640        650        660 
SGLCPEKILP EEKPAHLPVL RRSKSQSRPQ QVKFSDDVID NGSYDIEIRQ PPMSERTRRR 

       670        680        690        700        710        720 
AYHFEERGSR PHHHRHRRSR KSRSDNALNL VTERKYSAKD RLRLYTPDNY EKFIQNKSAR 

       730        740        750        760        770        780 
ELQAYMQNAN LYSQYAHATS DYALQNPGMN RFLGLCGEDD DSWCSSSTSS SDSEEEGYFL 

       790        800        810        820        830 
GQPIPQPRPQ RFTYYTDDLS SPASALPTPQ FTQRTTKSKK KKGHKGKNCI IS

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK153711 mRNA. Translation: BAE32152.1.
BC117892 mRNA. Translation: AAI17893.1.
BC117893 mRNA. Translation: AAI17894.1.
IPIIPI00406465.
RefSeqNP_001028389.1.
UniGeneMm.476820

3D structure databases

SMRQ3U5C7. Positions 124-262.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3U5C7.

PTM databases

PhosphoSiteQ3U5C7.

Proteomic databases

PRIDEQ3U5C7.

Genome annotation databases

EnsemblENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158; Mus musculus. [Genome view]
ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158; Mus musculus. [Genome view]
GeneID106042.
KEGGmmu:106042.
UCSCuc007xja.1. mouse.

Organism-specific databases

CTD106042.
MGIMGI:1916034. Prickle1.

Phylogenomic databases

eggNOGroNOG13089.
HOGENOMHBG447030.
HOVERGENQ3U5C7.
InParanoidQ3U5C7.
OMACCLECET.
OrthoDBEOG9NP9NT.

Gene expression databases

ArrayExpressQ3U5C7.
BgeeQ3U5C7.
CleanExMM_PRICKLE1.
GenevestigatorQ3U5C7.

Family and domain databases

InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
Gene3DG3DSA:2.10.110.10. Znf_LIM. 2 hits.
PfamPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 3 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio358030.
SOURCESearch...

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Entry information

Entry namePRIC1_MOUSE
AccessionPrimary (citable) accession number: Q3U5C7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents