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Protein

Prickle-like protein 1

Gene

Prickle1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Prickle-like protein 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916034. Prickle1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nuclear membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830271 – 829Prickle-like protein 1Add BLAST829
PropeptideiPRO_0000396713830 – 832Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei829Cysteine methyl esterBy similarity1
Lipidationi829S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ3U5C7.
PeptideAtlasiQ3U5C7.
PRIDEiQ3U5C7.

PTM databases

iPTMnetiQ3U5C7.
PhosphoSitePlusiQ3U5C7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036158.
CleanExiMM_PRICKLE1.
GenevisibleiQ3U5C7. MM.

Interactioni

Subunit structurei

Interacts with REST.By similarity

Protein-protein interaction databases

BioGridi222980. 1 interactor.
STRINGi10090.ENSMUSP00000049204.

Structurei

3D structure databases

ProteinModelPortaliQ3U5C7.
SMRiQ3U5C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 122PETPROSITE-ProRule annotationAdd BLAST109
Domaini124 – 188LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST65
Domaini189 – 249LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini250 – 313LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi817 – 822Poly-Lys6

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated
Contains 3 LIM zinc-binding domains.PROSITE-ProRule annotation
Contains 1 PET domain.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
HOGENOMiHOG000290649.
HOVERGENiHBG053679.
InParanoidiQ3U5C7.
KOiK04511.
OMAiCCLECET.
OrthoDBiEOG091G07C5.
PhylomeDBiQ3U5C7.
TreeFamiTF313265.

Family and domain databases

CDDicd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U5C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLEMEPKMS KLVFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA
60 70 80 90 100
CLPEEKVPYV NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF
110 120 130 140 150
SAQRKKEALG RGTIKLLSRA VMHAVCEQCG LQMNGGEVAV FASRAGPGVC
160 170 180 190 200
WHPSCFVCFT CNELLVDLIY FYQDGKIHCG RHHAELLKPR CSACDEIIFA
210 220 230 240 250
DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC GCFESLYAEY
260 270 280 290 300
CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI
310 320 330 340 350
YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL
360 370 380 390 400
LLSPALNYKF PGLSGNADDT LSRKLDDVSL ASRQGAGFAN EEFWKARVEQ
410 420 430 440 450
EASEDPEEWA EHEDYMTQLL LKFGDKNLFQ QQSSEVDPRA SEHWIPDNMV
460 470 480 490 500
TNKPEVKPNH QGLASKKYQS DMYWAQSQDG LGDSAYGSHP GPASSRRLQE
510 520 530 540 550
LDLDHGAAGY THDQSQWYED SLECLSDLKP EQSIRDSMDS LALSNITGAS
560 570 580 590 600
VDGESKPRPS LYSLQNFEEI EAEDCEKMSN MGTLNSSMLH RSAESLQSLN
610 620 630 640 650
SGLCPEKILP EEKPAHLPVL RRSKSQSRPQ QVKFSDDVID NGSYDIEIRQ
660 670 680 690 700
PPMSERTRRR AYHFEERGSR PHHHRHRRSR KSRSDNALNL VTERKYSAKD
710 720 730 740 750
RLRLYTPDNY EKFIQNKSAR ELQAYMQNAN LYSQYAHATS DYALQNPGMN
760 770 780 790 800
RFLGLCGEDD DSWCSSSTSS SDSEEEGYFL GQPIPQPRPQ RFTYYTDDLS
810 820 830
SPASALPTPQ FTQRTTKSKK KKGHKGKNCI IS
Length:832
Mass (Da):94,131
Last modified:October 11, 2005 - v1
Checksum:i8E664AAEA2E23CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153711 mRNA. Translation: BAE32152.1.
BC117892 mRNA. Translation: AAI17893.1.
BC117893 mRNA. Translation: AAI17894.1.
CCDSiCCDS27769.1.
RefSeqiNP_001028389.1. NM_001033217.4.
XP_006520327.1. XM_006520264.3.
XP_006520328.1. XM_006520265.1.
XP_006520329.1. XM_006520266.3.
UniGeneiMm.150314.

Genome annotation databases

EnsembliENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158.
ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158.
GeneIDi106042.
KEGGimmu:106042.
UCSCiuc007xja.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153711 mRNA. Translation: BAE32152.1.
BC117892 mRNA. Translation: AAI17893.1.
BC117893 mRNA. Translation: AAI17894.1.
CCDSiCCDS27769.1.
RefSeqiNP_001028389.1. NM_001033217.4.
XP_006520327.1. XM_006520264.3.
XP_006520328.1. XM_006520265.1.
XP_006520329.1. XM_006520266.3.
UniGeneiMm.150314.

3D structure databases

ProteinModelPortaliQ3U5C7.
SMRiQ3U5C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222980. 1 interactor.
STRINGi10090.ENSMUSP00000049204.

PTM databases

iPTMnetiQ3U5C7.
PhosphoSitePlusiQ3U5C7.

Proteomic databases

PaxDbiQ3U5C7.
PeptideAtlasiQ3U5C7.
PRIDEiQ3U5C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158.
ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158.
GeneIDi106042.
KEGGimmu:106042.
UCSCiuc007xja.1. mouse.

Organism-specific databases

CTDi144165.
MGIiMGI:1916034. Prickle1.

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
GeneTreeiENSGT00550000074438.
HOGENOMiHOG000290649.
HOVERGENiHBG053679.
InParanoidiQ3U5C7.
KOiK04511.
OMAiCCLECET.
OrthoDBiEOG091G07C5.
PhylomeDBiQ3U5C7.
TreeFamiTF313265.

Enzyme and pathway databases

ReactomeiR-MMU-4608870. Asymmetric localization of PCP proteins.

Miscellaneous databases

ChiTaRSiPrickle1. mouse.
PROiQ3U5C7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036158.
CleanExiMM_PRICKLE1.
GenevisibleiQ3U5C7. MM.

Family and domain databases

CDDicd09418. LIM2_Prickle. 1 hit.
cd09420. LIM3_Prickle. 1 hit.
cd09827. PET_Prickle. 1 hit.
Gene3Di2.10.110.10. 3 hits.
InterProiIPR033726. LIM2_prickle.
IPR033727. LIM3_prickle.
IPR010442. PET_domain.
IPR033723. PET_prickle.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 3 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 3 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 3 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRIC1_MOUSE
AccessioniPrimary (citable) accession number: Q3U5C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.