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Protein
Submitted name:

Tumor necrosis factor

Gene

Tnf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factorImported
Submitted name:
Tumor necrosis factor alphaImported
Submitted name:
Tumor necrosis factor, isoform CRA_bImported
Gene namesi
Name:TnfImported
Synonyms:TNFAImported
ORF Names:mCG_15911Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104798 Tnf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 56HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024401
ExpressionAtlasiQ3U593 baseline and differential

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3U593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 235TNF_2InterPro annotationAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 118Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISAN Eukaryota
ENOG410YQC4 LUCA
HOVERGENiHBG012516
KOiK03156
OMAiPWYEPIY
OrthoDBiEOG091G0HIG

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3U593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ
110 120 130 140 150
VEEQLEWLSQ RANALLANGM DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD
160 170 180 190 200
YVLLTHTVSR FAISYQEKVN LLSAVKSPCP KDTPEGAELK PWYEPIYLGG
210 220 230
VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL
Length:235
Mass (Da):25,896
Last modified:October 11, 2005 - v1
Checksum:i16DD2A9676D68C5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC117057 mRNA Translation: AAI17058.1
BC137720 mRNA Translation: AAI37721.1
AK153319 mRNA Translation: BAE31899.1
AK153800 mRNA Translation: BAE32187.1
AK155964 mRNA Translation: BAE33525.1
AB185894 Genomic DNA Translation: BAF02298.1
CH466666 Genomic DNA Translation: EDL26632.1
RefSeqiNP_038721.1, NM_013693.3
UniGeneiMm.1293

Genome annotation databases

GeneIDi21926
KEGGimmu:21926

Similar proteinsi

Entry informationi

Entry nameiQ3U593_MOUSE
AccessioniPrimary (citable) accession number: Q3U593
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health