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Q3U515

- VWCE_MOUSE

UniProt

Q3U515 - VWCE_MOUSE

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Protein

von Willebrand factor C and EGF domain-containing protein

Gene

Vwce

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C and EGF domain-containing protein
Gene namesi
Name:Vwce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1919018. Vwce.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 929908von Willebrand factor C and EGF domain-containing proteinPRO_0000318581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
Disulfide bondi151 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 179PROSITE-ProRule annotation
Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
Disulfide bondi190 ↔ 203PROSITE-ProRule annotation
Disulfide bondi205 ↔ 218PROSITE-ProRule annotation
Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
Disulfide bondi233 ↔ 246PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U515.
PRIDEiQ3U515.

PTM databases

PhosphoSiteiQ3U515.

Expressioni

Gene expression databases

BgeeiQ3U515.
CleanExiMM_VWCE.
GenevestigatoriQ3U515.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056958.

Structurei

3D structure databases

ProteinModelPortaliQ3U515.
SMRiQ3U515. Positions 41-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 9829EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini142 – 18039EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 21939EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini220 – 26243EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini376 – 43358VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 49462VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini491 – 55262VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini558 – 61861VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini619 – 67759VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini677 – 76286VWFC 6PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 36981Pro-richAdd
BLAST
Compositional biasi796 – 85459Pro-richAdd
BLAST
Compositional biasi856 – 8594Poly-Ser
Compositional biasi896 – 8994Poly-Ser

Sequence similaritiesi

Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG240200.
GeneTreeiENSGT00760000119335.
HOGENOMiHOG000168460.
HOVERGENiHBG067558.
InParanoidiQ3U515.
OMAiCTCVPVR.
OrthoDBiEOG7D2FCX.
TreeFamiTF330819.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U515-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG
60 70 80 90 100
SGCCPGWAPS MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA
110 120 130 140 150
HGSCGEYGCD LTCNHGGCQE VARVCPVGFL MTETAVGIRC ADIDECLSSS
160 170 180 190 200
CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS
210 220 230 240 250
YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT VGSFLCTCRP
260 270 280 290 300
GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH
310 320 330 340 350
SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP
360 370 380 390 400
SLLQGAVGTP SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL
410 420 430 440 450
CQDGEVTCGG VRCDATCSHP VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP
460 470 480 490 500
PEENCTVCVC LAGNVSCISP ECPPGPCKAS PQSDCCTCVP GRCYFHGRWY
510 520 530 540 550
TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW LLGPGQCCFT
560 570 580 590 600
CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV
610 620 630 640 650
DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS
660 670 680 690 700
VACSPVDCPI TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT
710 720 730 740 750
RCICQLGEVS CETVPCRPIC TDPSCPDSVF PLEEKQQPSP HGELAKAARN
760 770 780 790 800
ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL QRLLRTNLSN IQSASPSPPI
810 820 830 840 850
AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL PPAIPGTPLS
860 870 880 890 900
PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ
910 920
RLSAALPDTP NPVPQQSTID TPKKENSTI
Length:929
Mass (Da):97,668
Last modified:July 27, 2011 - v2
Checksum:iEDE1A8EA0272E119
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti344 – 3441L → P in BAE32265. (PubMed:16141072)Curated
Sequence conflicti375 – 3751S → P in BAE32265. (PubMed:16141072)Curated
Sequence conflicti777 – 7771V → I in BAE32265. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153937 mRNA. Translation: BAE32265.1.
AC132247 Genomic DNA. No translation available.
CCDSiCCDS50390.1.
RefSeqiNP_082189.1. NM_027913.1.
UniGeneiMm.169261.

Genome annotation databases

EnsembliENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
GeneIDi71768.
KEGGimmu:71768.
UCSCiuc008gqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153937 mRNA. Translation: BAE32265.1 .
AC132247 Genomic DNA. No translation available.
CCDSi CCDS50390.1.
RefSeqi NP_082189.1. NM_027913.1.
UniGenei Mm.169261.

3D structure databases

ProteinModelPortali Q3U515.
SMRi Q3U515. Positions 41-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000056958.

PTM databases

PhosphoSitei Q3U515.

Proteomic databases

PaxDbi Q3U515.
PRIDEi Q3U515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055115 ; ENSMUSP00000056958 ; ENSMUSG00000043789 .
GeneIDi 71768.
KEGGi mmu:71768.
UCSCi uc008gqo.2. mouse.

Organism-specific databases

CTDi 220001.
MGIi MGI:1919018. Vwce.

Phylogenomic databases

eggNOGi NOG240200.
GeneTreei ENSGT00760000119335.
HOGENOMi HOG000168460.
HOVERGENi HBG067558.
InParanoidi Q3U515.
OMAi CTCVPVR.
OrthoDBi EOG7D2FCX.
TreeFami TF330819.

Miscellaneous databases

NextBioi 334455.
PROi Q3U515.
SOURCEi Search...

Gene expression databases

Bgeei Q3U515.
CleanExi MM_VWCE.
Genevestigatori Q3U515.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiVWCE_MOUSE
AccessioniPrimary (citable) accession number: Q3U515
Secondary accession number(s): E9QME6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3