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Q3U515

- VWCE_MOUSE

UniProt

Q3U515 - VWCE_MOUSE

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Protein
von Willebrand factor C and EGF domain-containing protein
Gene
Vwce
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C and EGF domain-containing protein
Gene namesi
Name:Vwce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1919018. Vwce.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 929908von Willebrand factor C and EGF domain-containing protein
PRO_0000318581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 155 By similarity
Disulfide bondi151 ↔ 164 By similarity
Disulfide bondi166 ↔ 179 By similarity
Disulfide bondi185 ↔ 194 By similarity
Disulfide bondi190 ↔ 203 By similarity
Disulfide bondi205 ↔ 218 By similarity
Disulfide bondi224 ↔ 237 By similarity
Disulfide bondi233 ↔ 246 By similarity
Disulfide bondi248 ↔ 261 By similarity
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi787 – 7871N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U515.
PRIDEiQ3U515.

PTM databases

PhosphoSiteiQ3U515.

Expressioni

Gene expression databases

BgeeiQ3U515.
CleanExiMM_VWCE.
GenevestigatoriQ3U515.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056958.

Structurei

3D structure databases

ProteinModelPortaliQ3U515.
SMRiQ3U515. Positions 41-288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 9829EGF-like 1
Add
BLAST
Domaini142 – 18039EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini181 – 21939EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini220 – 26243EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini376 – 43358VWFC 1
Add
BLAST
Domaini433 – 49462VWFC 2
Add
BLAST
Domaini491 – 55262VWFC 3
Add
BLAST
Domaini558 – 61861VWFC 4
Add
BLAST
Domaini619 – 67759VWFC 5
Add
BLAST
Domaini677 – 76286VWFC 6
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi289 – 36981Pro-rich
Add
BLAST
Compositional biasi796 – 85459Pro-rich
Add
BLAST
Compositional biasi856 – 8594Poly-Ser
Compositional biasi896 – 8994Poly-Ser

Sequence similaritiesi

Contains 4 EGF-like domains.
Contains 6 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG240200.
GeneTreeiENSGT00730000110775.
HOGENOMiHOG000168460.
HOVERGENiHBG067558.
InParanoidiQ3U515.
OMAiCTCVPVR.
OrthoDBiEOG7D2FCX.
TreeFamiTF330819.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U515-1 [UniParc]FASTAAdd to Basket

« Hide

MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG    50
SGCCPGWAPS MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA 100
HGSCGEYGCD LTCNHGGCQE VARVCPVGFL MTETAVGIRC ADIDECLSSS 150
CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS 200
YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT VGSFLCTCRP 250
GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH 300
SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP 350
SLLQGAVGTP SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL 400
CQDGEVTCGG VRCDATCSHP VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP 450
PEENCTVCVC LAGNVSCISP ECPPGPCKAS PQSDCCTCVP GRCYFHGRWY 500
TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW LLGPGQCCFT 550
CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV 600
DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS 650
VACSPVDCPI TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT 700
RCICQLGEVS CETVPCRPIC TDPSCPDSVF PLEEKQQPSP HGELAKAARN 750
ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL QRLLRTNLSN IQSASPSPPI 800
AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL PPAIPGTPLS 850
PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ 900
RLSAALPDTP NPVPQQSTID TPKKENSTI 929
Length:929
Mass (Da):97,668
Last modified:July 27, 2011 - v2
Checksum:iEDE1A8EA0272E119
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti344 – 3441L → P in BAE32265. 1 Publication
Sequence conflicti375 – 3751S → P in BAE32265. 1 Publication
Sequence conflicti777 – 7771V → I in BAE32265. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK153937 mRNA. Translation: BAE32265.1.
AC132247 Genomic DNA. No translation available.
CCDSiCCDS50390.1.
RefSeqiNP_082189.1. NM_027913.1.
UniGeneiMm.169261.

Genome annotation databases

EnsembliENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
GeneIDi71768.
KEGGimmu:71768.
UCSCiuc008gqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK153937 mRNA. Translation: BAE32265.1 .
AC132247 Genomic DNA. No translation available.
CCDSi CCDS50390.1.
RefSeqi NP_082189.1. NM_027913.1.
UniGenei Mm.169261.

3D structure databases

ProteinModelPortali Q3U515.
SMRi Q3U515. Positions 41-288.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000056958.

PTM databases

PhosphoSitei Q3U515.

Proteomic databases

PaxDbi Q3U515.
PRIDEi Q3U515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055115 ; ENSMUSP00000056958 ; ENSMUSG00000043789 .
GeneIDi 71768.
KEGGi mmu:71768.
UCSCi uc008gqo.2. mouse.

Organism-specific databases

CTDi 220001.
MGIi MGI:1919018. Vwce.

Phylogenomic databases

eggNOGi NOG240200.
GeneTreei ENSGT00730000110775.
HOGENOMi HOG000168460.
HOVERGENi HBG067558.
InParanoidi Q3U515.
OMAi CTCVPVR.
OrthoDBi EOG7D2FCX.
TreeFami TF330819.

Miscellaneous databases

NextBioi 334455.
PROi Q3U515.
SOURCEi Search...

Gene expression databases

Bgeei Q3U515.
CleanExi MM_VWCE.
Genevestigatori Q3U515.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiVWCE_MOUSE
AccessioniPrimary (citable) accession number: Q3U515
Secondary accession number(s): E9QME6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi