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Q3U515 (VWCE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
von Willebrand factor C and EGF domain-containing protein
Gene names
Name:Vwce
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length929 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Contains 4 EGF-like domains.

Contains 6 VWFC domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 929908von Willebrand factor C and EGF domain-containing protein
PRO_0000318581

Regions

Domain70 – 9829EGF-like 1
Domain142 – 18039EGF-like 2; calcium-binding Potential
Domain181 – 21939EGF-like 3; calcium-binding Potential
Domain220 – 26243EGF-like 4; calcium-binding Potential
Domain376 – 43358VWFC 1
Domain433 – 49462VWFC 2
Domain491 – 55262VWFC 3
Domain558 – 61861VWFC 4
Domain619 – 67759VWFC 5
Domain677 – 76286VWFC 6
Compositional bias289 – 36981Pro-rich
Compositional bias796 – 85459Pro-rich
Compositional bias856 – 8594Poly-Ser
Compositional bias896 – 8994Poly-Ser

Amino acid modifications

Glycosylation4541N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential
Glycosylation7871N-linked (GlcNAc...) Potential
Disulfide bond146 ↔ 155 By similarity
Disulfide bond151 ↔ 164 By similarity
Disulfide bond166 ↔ 179 By similarity
Disulfide bond185 ↔ 194 By similarity
Disulfide bond190 ↔ 203 By similarity
Disulfide bond205 ↔ 218 By similarity
Disulfide bond224 ↔ 237 By similarity
Disulfide bond233 ↔ 246 By similarity
Disulfide bond248 ↔ 261 By similarity

Experimental info

Sequence conflict3441L → P in BAE32265. Ref.1
Sequence conflict3751S → P in BAE32265. Ref.1
Sequence conflict7771V → I in BAE32265. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3U515 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: EDE1A8EA0272E119

FASTA92997,668
        10         20         30         40         50         60 
MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG SGCCPGWAPS 

        70         80         90        100        110        120 
MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA HGSCGEYGCD LTCNHGGCQE 

       130        140        150        160        170        180 
VARVCPVGFL MTETAVGIRC ADIDECLSSS CEGHCVNTEG GFVCECGPGM QLSADRHSCQ 

       190        200        210        220        230        240 
DTDECLGTPC QQRCKNSIGS YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT 

       250        260        270        280        290        300 
VGSFLCTCRP GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH 

       310        320        330        340        350        360 
SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP SLLQGAVGTP 

       370        380        390        400        410        420 
SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL CQDGEVTCGG VRCDATCSHP 

       430        440        450        460        470        480 
VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP PEENCTVCVC LAGNVSCISP ECPPGPCKAS 

       490        500        510        520        530        540 
PQSDCCTCVP GRCYFHGRWY TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW 

       550        560        570        580        590        600 
LLGPGQCCFT CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV 

       610        620        630        640        650        660 
DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS VACSPVDCPI 

       670        680        690        700        710        720 
TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT RCICQLGEVS CETVPCRPIC 

       730        740        750        760        770        780 
TDPSCPDSVF PLEEKQQPSP HGELAKAARN ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL 

       790        800        810        820        830        840 
QRLLRTNLSN IQSASPSPPI AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL 

       850        860        870        880        890        900 
PPAIPGTPLS PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ 

       910        920 
RLSAALPDTP NPVPQQSTID TPKKENSTI 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Thymus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK153937 mRNA. Translation: BAE32265.1.
AC132247 Genomic DNA. No translation available.
RefSeqNP_082189.1. NM_027913.1.
UniGeneMm.169261.

3D structure databases

ProteinModelPortalQ3U515.
SMRQ3U515. Positions 41-288, 375-433, 490-554, 562-719.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056958.

PTM databases

PhosphoSiteQ3U515.

Proteomic databases

PaxDbQ3U515.
PRIDEQ3U515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
GeneID71768.
KEGGmmu:71768.
UCSCuc008gqo.2. mouse.

Organism-specific databases

CTD220001.
MGIMGI:1919018. Vwce.

Phylogenomic databases

eggNOGNOG240200.
GeneTreeENSGT00730000110775.
HOGENOMHOG000168460.
HOVERGENHBG067558.
InParanoidQ3U515.
OMACTCVPVR.
OrthoDBEOG7D2FCX.
TreeFamTF330819.

Gene expression databases

BgeeQ3U515.
CleanExMM_VWCE.
GenevestigatorQ3U515.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamPF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio334455.
PROQ3U515.
SOURCESearch...

Entry information

Entry nameVWCE_MOUSE
AccessionPrimary (citable) accession number: Q3U515
Secondary accession number(s): E9QME6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot