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Q3U515

- VWCE_MOUSE

UniProt

Q3U515 - VWCE_MOUSE

Protein

von Willebrand factor C and EGF domain-containing protein

Gene

Vwce

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    von Willebrand factor C and EGF domain-containing protein
    Gene namesi
    Name:Vwce
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1919018. Vwce.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 929908von Willebrand factor C and EGF domain-containing proteinPRO_0000318581Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi151 ↔ 164PROSITE-ProRule annotation
    Disulfide bondi166 ↔ 179PROSITE-ProRule annotation
    Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
    Disulfide bondi190 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
    Disulfide bondi233 ↔ 246PROSITE-ProRule annotation
    Disulfide bondi248 ↔ 261PROSITE-ProRule annotation
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ3U515.
    PRIDEiQ3U515.

    PTM databases

    PhosphoSiteiQ3U515.

    Expressioni

    Gene expression databases

    BgeeiQ3U515.
    CleanExiMM_VWCE.
    GenevestigatoriQ3U515.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U515.
    SMRiQ3U515. Positions 41-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 9829EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 18039EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 21939EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini220 – 26243EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini376 – 43358VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini433 – 49462VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini491 – 55262VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini558 – 61861VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini619 – 67759VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 76286VWFC 6PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi289 – 36981Pro-richAdd
    BLAST
    Compositional biasi796 – 85459Pro-richAdd
    BLAST
    Compositional biasi856 – 8594Poly-Ser
    Compositional biasi896 – 8994Poly-Ser

    Sequence similaritiesi

    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG240200.
    GeneTreeiENSGT00730000110775.
    HOGENOMiHOG000168460.
    HOVERGENiHBG067558.
    InParanoidiQ3U515.
    OMAiCTCVPVR.
    OrthoDBiEOG7D2FCX.
    TreeFamiTF330819.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07645. EGF_CA. 3 hits.
    PF00093. VWC. 3 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 4 hits.
    PS50184. VWFC_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3U515-1 [UniParc]FASTAAdd to Basket

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    MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG    50
    SGCCPGWAPS MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA 100
    HGSCGEYGCD LTCNHGGCQE VARVCPVGFL MTETAVGIRC ADIDECLSSS 150
    CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS 200
    YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT VGSFLCTCRP 250
    GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH 300
    SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP 350
    SLLQGAVGTP SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL 400
    CQDGEVTCGG VRCDATCSHP VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP 450
    PEENCTVCVC LAGNVSCISP ECPPGPCKAS PQSDCCTCVP GRCYFHGRWY 500
    TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW LLGPGQCCFT 550
    CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV 600
    DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS 650
    VACSPVDCPI TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT 700
    RCICQLGEVS CETVPCRPIC TDPSCPDSVF PLEEKQQPSP HGELAKAARN 750
    ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL QRLLRTNLSN IQSASPSPPI 800
    AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL PPAIPGTPLS 850
    PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ 900
    RLSAALPDTP NPVPQQSTID TPKKENSTI 929
    Length:929
    Mass (Da):97,668
    Last modified:July 27, 2011 - v2
    Checksum:iEDE1A8EA0272E119
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti344 – 3441L → P in BAE32265. (PubMed:16141072)Curated
    Sequence conflicti375 – 3751S → P in BAE32265. (PubMed:16141072)Curated
    Sequence conflicti777 – 7771V → I in BAE32265. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK153937 mRNA. Translation: BAE32265.1.
    AC132247 Genomic DNA. No translation available.
    CCDSiCCDS50390.1.
    RefSeqiNP_082189.1. NM_027913.1.
    UniGeneiMm.169261.

    Genome annotation databases

    EnsembliENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
    GeneIDi71768.
    KEGGimmu:71768.
    UCSCiuc008gqo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK153937 mRNA. Translation: BAE32265.1 .
    AC132247 Genomic DNA. No translation available.
    CCDSi CCDS50390.1.
    RefSeqi NP_082189.1. NM_027913.1.
    UniGenei Mm.169261.

    3D structure databases

    ProteinModelPortali Q3U515.
    SMRi Q3U515. Positions 41-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056958.

    PTM databases

    PhosphoSitei Q3U515.

    Proteomic databases

    PaxDbi Q3U515.
    PRIDEi Q3U515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055115 ; ENSMUSP00000056958 ; ENSMUSG00000043789 .
    GeneIDi 71768.
    KEGGi mmu:71768.
    UCSCi uc008gqo.2. mouse.

    Organism-specific databases

    CTDi 220001.
    MGIi MGI:1919018. Vwce.

    Phylogenomic databases

    eggNOGi NOG240200.
    GeneTreei ENSGT00730000110775.
    HOGENOMi HOG000168460.
    HOVERGENi HBG067558.
    InParanoidi Q3U515.
    OMAi CTCVPVR.
    OrthoDBi EOG7D2FCX.
    TreeFami TF330819.

    Miscellaneous databases

    NextBioi 334455.
    PROi Q3U515.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3U515.
    CleanExi MM_VWCE.
    Genevestigatori Q3U515.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 3 hits.
    PF00093. VWC. 3 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 4 hits.
    PS50184. VWFC_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiVWCE_MOUSE
    AccessioniPrimary (citable) accession number: Q3U515
    Secondary accession number(s): E9QME6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3