Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

von Willebrand factor C and EGF domain-containing protein

Gene

Vwce

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C and EGF domain-containing protein
Gene namesi
Name:Vwce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1919018. Vwce.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031858122 – 929von Willebrand factor C and EGF domain-containing proteinAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
Disulfide bondi151 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 179PROSITE-ProRule annotation
Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
Disulfide bondi190 ↔ 203PROSITE-ProRule annotation
Disulfide bondi205 ↔ 218PROSITE-ProRule annotation
Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
Disulfide bondi233 ↔ 246PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Glycosylationi464N-linked (GlcNAc...)Sequence analysis1
Glycosylationi787N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U515.
PRIDEiQ3U515.

PTM databases

iPTMnetiQ3U515.
PhosphoSitePlusiQ3U515.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043789.
CleanExiMM_VWCE.
GenevisibleiQ3U515. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056958.

Structurei

3D structure databases

ProteinModelPortaliQ3U515.
SMRiQ3U515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 98EGF-like 1PROSITE-ProRule annotationAdd BLAST29
Domaini142 – 180EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini181 – 219EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini220 – 262EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini376 – 433VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini433 – 494VWFC 2PROSITE-ProRule annotationAdd BLAST62
Domaini491 – 552VWFC 3PROSITE-ProRule annotationAdd BLAST62
Domaini558 – 618VWFC 4PROSITE-ProRule annotationAdd BLAST61
Domaini619 – 677VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini677 – 762VWFC 6PROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 369Pro-richAdd BLAST81
Compositional biasi796 – 854Pro-richAdd BLAST59
Compositional biasi856 – 859Poly-Ser4
Compositional biasi896 – 899Poly-Ser4

Sequence similaritiesi

Contains 4 EGF-like domains.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
KOG1217. Eukaryota.
ENOG4110VWF. LUCA.
GeneTreeiENSGT00840000129763.
HOGENOMiHOG000168460.
HOVERGENiHBG067558.
InParanoidiQ3U515.
OMAiRCTCQLG.
OrthoDBiEOG091G01PY.
TreeFamiTF330819.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR030123. Vwce.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR11339:SF250. PTHR11339:SF250. 2 hits.
PfamiPF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWARLLLHVA YILIPLLGSS ARGYTGRKAP GHYSAERRRL GPHVCLSGFG
60 70 80 90 100
SGCCPGWAPS MGSGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPEA
110 120 130 140 150
HGSCGEYGCD LTCNHGGCQE VARVCPVGFL MTETAVGIRC ADIDECLSSS
160 170 180 190 200
CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS
210 220 230 240 250
YKCSCRAGFH LHGNRHSCID VNECRRPQER RVCHHTCHNT VGSFLCTCRP
260 270 280 290 300
GFRLRSDRVS CEAFPKAVLA PSAILQPRQH PAKMSLLLPE AGRPALSPGH
310 320 330 340 350
SPPPGAPGYP TGVRTISQPS TTQVLPTFFP TQLISTPVPS SSPLGTLGPP
360 370 380 390 400
SLLQGAVGTP SSPRGPESPK LGAGSSSCWH LGATYESGSR WNQPGCSQCL
410 420 430 440 450
CQDGEVTCGG VRCDATCSHP VPPRDGGCCP SCTGCFHSGA IRAEGDVFSP
460 470 480 490 500
PEENCTVCVC LAGNVSCISP ECPPGPCKAS PQSDCCTCVP GRCYFHGRWY
510 520 530 540 550
TDGAVFSGGG DDCTTCVCQN GEVECSFTPC PELECPREEW LLGPGQCCFT
560 570 580 590 600
CREPTPTTGC SLDDNGVEFP IGQIWSPGDP CELCVCQADG SVSCKRTDCV
610 620 630 640 650
DSCPHPIRIP GQCCPDCSAG CTYTGRIFYN NETFPSVLDP CLSCICLLGS
660 670 680 690 700
VACSPVDCPI TCTYPFHPDG ECCPVCHDCN FEGRKVVNGQ VFTLDDEPCT
710 720 730 740 750
RCICQLGEVS CETVPCRPIC TDPSCPDSVF PLEEKQQPSP HGELAKAARN
760 770 780 790 800
ARGDTEVPVN CSSCPGPPSA SPTRPMVHLL QRLLRTNLSN IQSASPSPPI
810 820 830 840 850
AQTSSSPLLE PEGISLGKPR ASQPPEPSAG SPVSPRLSTL PPAIPGTPLS
860 870 880 890 900
PVTPESSSST FGTQTAFQWL LSATPLTEAE TPSMTNADLS ETLTTSSSSQ
910 920
RLSAALPDTP NPVPQQSTID TPKKENSTI
Length:929
Mass (Da):97,668
Last modified:July 27, 2011 - v2
Checksum:iEDE1A8EA0272E119
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344L → P in BAE32265 (PubMed:16141072).Curated1
Sequence conflicti375S → P in BAE32265 (PubMed:16141072).Curated1
Sequence conflicti777V → I in BAE32265 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153937 mRNA. Translation: BAE32265.1.
AC132247 Genomic DNA. No translation available.
CCDSiCCDS50390.1.
RefSeqiNP_082189.1. NM_027913.1.
UniGeneiMm.169261.

Genome annotation databases

EnsembliENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
GeneIDi71768.
KEGGimmu:71768.
UCSCiuc008gqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153937 mRNA. Translation: BAE32265.1.
AC132247 Genomic DNA. No translation available.
CCDSiCCDS50390.1.
RefSeqiNP_082189.1. NM_027913.1.
UniGeneiMm.169261.

3D structure databases

ProteinModelPortaliQ3U515.
SMRiQ3U515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056958.

PTM databases

iPTMnetiQ3U515.
PhosphoSitePlusiQ3U515.

Proteomic databases

PaxDbiQ3U515.
PRIDEiQ3U515.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055115; ENSMUSP00000056958; ENSMUSG00000043789.
GeneIDi71768.
KEGGimmu:71768.
UCSCiuc008gqo.2. mouse.

Organism-specific databases

CTDi220001.
MGIiMGI:1919018. Vwce.

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
KOG1217. Eukaryota.
ENOG4110VWF. LUCA.
GeneTreeiENSGT00840000129763.
HOGENOMiHOG000168460.
HOVERGENiHBG067558.
InParanoidiQ3U515.
OMAiRCTCQLG.
OrthoDBiEOG091G01PY.
TreeFamiTF330819.

Miscellaneous databases

PROiQ3U515.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043789.
CleanExiMM_VWCE.
GenevisibleiQ3U515. MM.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR030123. Vwce.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR11339:SF250. PTHR11339:SF250. 2 hits.
PfamiPF07645. EGF_CA. 3 hits.
PF00093. VWC. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 4 hits.
PS50184. VWFC_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVWCE_MOUSE
AccessioniPrimary (citable) accession number: Q3U515
Secondary accession number(s): E9QME6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.