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Protein

Probable G-protein coupled receptor 174

Gene

Gpr174

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

  • bioactive lipid receptor activity Source: MGI

GO - Biological processi

  • T cell homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 174
Gene namesi
Name:Gpr174
Synonyms:Gm376
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685222. Gpr174.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 53CytoplasmicSequence analysis5
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 134CytoplasmicSequence analysisAdd BLAST22
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 182ExtracellularSequence analysisAdd BLAST27
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 231CytoplasmicSequence analysisAdd BLAST28
Transmembranei232 – 252Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini253 – 268ExtracellularSequence analysisAdd BLAST16
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 335CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696551 – 335Probable G-protein coupled receptor 174Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U507.
PRIDEiQ3U507.

PTM databases

iPTMnetiQ3U507.
PhosphoSitePlusiQ3U507.

Expressioni

Tissue specificityi

Expressed in spleen and, at low levels, in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000073008.
CleanExiMM_GPR174.
GenevisibleiQ3U507. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098852.

Structurei

3D structure databases

ProteinModelPortaliQ3U507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ3U507.
KOiK08391.
OMAiFTTDEFR.
OrthoDBiEOG091G0DAI.
PhylomeDBiQ3U507.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNFTCNKT DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE
60 70 80 90 100
TKRAVVFMIN LAIADLLQIL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV
110 120 130 140 150
NMYASIYFLV CISVRRFWFL MYPFRFNDCK QKYDLYISII GWLIICLACL
160 170 180 190 200
LFPLLRTNDD TPGNRTKCFV DLPIRNVNLA QSVAMITIGE VVGFVTPLMI
210 220 230 240 250
VLYCTWKTAL SLQNKYPISQ HLGEKKKALK MILTCAGVFL VCFVPYHFSF
260 270 280 290 300
PLDFLVKSNE IKSCFARRVI LIFHSVALCL ASLNSCLDPV IYYFTTNEFR
310 320 330
RRLSRQDLPD NIQLHTKSYK IASNHATSTV AAELC
Length:335
Mass (Da):38,761
Last modified:October 11, 2005 - v1
Checksum:iE1125388C0A7923D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153611 mRNA. Translation: BAE32116.1.
AK153950 mRNA. Translation: BAE32273.1.
AK156069 mRNA. Translation: BAE33570.1.
AK171832 mRNA. Translation: BAE42688.1.
CCDSiCCDS30348.1.
RefSeqiNP_001028423.1. NM_001033251.4.
NP_001171252.1. NM_001177781.1.
NP_001171253.1. NM_001177782.1.
UniGeneiMm.383562.

Genome annotation databases

EnsembliENSMUST00000101294; ENSMUSP00000098852; ENSMUSG00000073008.
ENSMUST00000117310; ENSMUSP00000112808; ENSMUSG00000073008.
ENSMUST00000118820; ENSMUSP00000113032; ENSMUSG00000073008.
ENSMUST00000120971; ENSMUSP00000112974; ENSMUSG00000073008.
ENSMUST00000178838; ENSMUSP00000137372; ENSMUSG00000073008.
GeneIDi213439.
KEGGimmu:213439.
UCSCiuc009ucd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153611 mRNA. Translation: BAE32116.1.
AK153950 mRNA. Translation: BAE32273.1.
AK156069 mRNA. Translation: BAE33570.1.
AK171832 mRNA. Translation: BAE42688.1.
CCDSiCCDS30348.1.
RefSeqiNP_001028423.1. NM_001033251.4.
NP_001171252.1. NM_001177781.1.
NP_001171253.1. NM_001177782.1.
UniGeneiMm.383562.

3D structure databases

ProteinModelPortaliQ3U507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098852.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3U507.
PhosphoSitePlusiQ3U507.

Proteomic databases

PaxDbiQ3U507.
PRIDEiQ3U507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101294; ENSMUSP00000098852; ENSMUSG00000073008.
ENSMUST00000117310; ENSMUSP00000112808; ENSMUSG00000073008.
ENSMUST00000118820; ENSMUSP00000113032; ENSMUSG00000073008.
ENSMUST00000120971; ENSMUSP00000112974; ENSMUSG00000073008.
ENSMUST00000178838; ENSMUSP00000137372; ENSMUSG00000073008.
GeneIDi213439.
KEGGimmu:213439.
UCSCiuc009ucd.2. mouse.

Organism-specific databases

CTDi84636.
MGIiMGI:2685222. Gpr174.

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ3U507.
KOiK08391.
OMAiFTTDEFR.
OrthoDBiEOG091G0DAI.
PhylomeDBiQ3U507.
TreeFamiTF350009.

Miscellaneous databases

PROiQ3U507.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073008.
CleanExiMM_GPR174.
GenevisibleiQ3U507. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP174_MOUSE
AccessioniPrimary (citable) accession number: Q3U507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.