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Protein

Probable G-protein coupled receptor 174

Gene

Gpr174

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.By similarity

GO - Molecular functioni

  • bioactive lipid receptor activity Source: MGI

GO - Biological processi

  • T cell homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 174
Gene namesi
Name:Gpr174
Synonyms:Gm376
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2685222. Gpr174.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 535CytoplasmicSequence analysis
Transmembranei54 – 7421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 9117ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13422CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini156 – 18227ExtracellularSequence analysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini204 – 23128CytoplasmicSequence analysisAdd
BLAST
Transmembranei232 – 25221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini253 – 26816ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 33546CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Probable G-protein coupled receptor 174PRO_0000069655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 168PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3U507.
PRIDEiQ3U507.

PTM databases

iPTMnetiQ3U507.
PhosphoSiteiQ3U507.

Expressioni

Tissue specificityi

Expressed in spleen and, at low levels, in brain.1 Publication

Gene expression databases

BgeeiQ3U507.
CleanExiMM_GPR174.
GenevisibleiQ3U507. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098852.

Structurei

3D structure databases

ProteinModelPortaliQ3U507.
SMRiQ3U507. Positions 4-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ3U507.
KOiK08391.
OMAiYFTTDEF.
OrthoDBiEOG72JWGC.
PhylomeDBiQ3U507.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNFTCNKT DGDNTDFRYF IYAVTYTVIL VPGLIGNILA LWVFYGYMKE
60 70 80 90 100
TKRAVVFMIN LAIADLLQIL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV
110 120 130 140 150
NMYASIYFLV CISVRRFWFL MYPFRFNDCK QKYDLYISII GWLIICLACL
160 170 180 190 200
LFPLLRTNDD TPGNRTKCFV DLPIRNVNLA QSVAMITIGE VVGFVTPLMI
210 220 230 240 250
VLYCTWKTAL SLQNKYPISQ HLGEKKKALK MILTCAGVFL VCFVPYHFSF
260 270 280 290 300
PLDFLVKSNE IKSCFARRVI LIFHSVALCL ASLNSCLDPV IYYFTTNEFR
310 320 330
RRLSRQDLPD NIQLHTKSYK IASNHATSTV AAELC
Length:335
Mass (Da):38,761
Last modified:October 11, 2005 - v1
Checksum:iE1125388C0A7923D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153611 mRNA. Translation: BAE32116.1.
AK153950 mRNA. Translation: BAE32273.1.
AK156069 mRNA. Translation: BAE33570.1.
AK171832 mRNA. Translation: BAE42688.1.
CCDSiCCDS30348.1.
RefSeqiNP_001028423.1. NM_001033251.4.
NP_001171252.1. NM_001177781.1.
NP_001171253.1. NM_001177782.1.
UniGeneiMm.383562.

Genome annotation databases

EnsembliENSMUST00000101294; ENSMUSP00000098852; ENSMUSG00000073008.
ENSMUST00000117310; ENSMUSP00000112808; ENSMUSG00000073008.
ENSMUST00000118820; ENSMUSP00000113032; ENSMUSG00000073008.
ENSMUST00000120971; ENSMUSP00000112974; ENSMUSG00000073008.
ENSMUST00000178838; ENSMUSP00000137372; ENSMUSG00000073008.
GeneIDi213439.
KEGGimmu:213439.
UCSCiuc009ucd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153611 mRNA. Translation: BAE32116.1.
AK153950 mRNA. Translation: BAE32273.1.
AK156069 mRNA. Translation: BAE33570.1.
AK171832 mRNA. Translation: BAE42688.1.
CCDSiCCDS30348.1.
RefSeqiNP_001028423.1. NM_001033251.4.
NP_001171252.1. NM_001177781.1.
NP_001171253.1. NM_001177782.1.
UniGeneiMm.383562.

3D structure databases

ProteinModelPortaliQ3U507.
SMRiQ3U507. Positions 4-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098852.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3U507.
PhosphoSiteiQ3U507.

Proteomic databases

PaxDbiQ3U507.
PRIDEiQ3U507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101294; ENSMUSP00000098852; ENSMUSG00000073008.
ENSMUST00000117310; ENSMUSP00000112808; ENSMUSG00000073008.
ENSMUST00000118820; ENSMUSP00000113032; ENSMUSG00000073008.
ENSMUST00000120971; ENSMUSP00000112974; ENSMUSG00000073008.
ENSMUST00000178838; ENSMUSP00000137372; ENSMUSG00000073008.
GeneIDi213439.
KEGGimmu:213439.
UCSCiuc009ucd.2. mouse.

Organism-specific databases

CTDi84636.
MGIiMGI:2685222. Gpr174.

Phylogenomic databases

eggNOGiENOG410IH6K. Eukaryota.
ENOG410ZJNT. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231258.
HOVERGENiHBG099867.
InParanoidiQ3U507.
KOiK08391.
OMAiYFTTDEF.
OrthoDBiEOG72JWGC.
PhylomeDBiQ3U507.
TreeFamiTF350009.

Miscellaneous databases

PROiQ3U507.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U507.
CleanExiMM_GPR174.
GenevisibleiQ3U507. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Thymus.
  2. "Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP."
    Sugita K., Yamamura C., Tabata K., Fujita N.
    Biochem. Biophys. Res. Commun. 430:190-195(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGP174_MOUSE
AccessioniPrimary (citable) accession number: Q3U507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.