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Protein

DNA ligase

Gene

Lig1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-110362. POLB-Dependent Long Patch Base Excision Repair.
R-MMU-174414. Processive synthesis on the C-strand of the telomere.
R-MMU-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-MMU-5358606. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
R-MMU-5651801. PCNA-Dependent Long Patch Base Excision Repair.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-MMU-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Lig1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:101789. Lig1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000056394.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini662 – 798DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967. Eukaryota.
COG1793. LUCA.
GeneTreeiENSGT00860000133792.
HOGENOMiHOG000036006.
HOVERGENiHBG005514.
KOiK10747.
OMAiETVCNIG.
OrthoDBiEOG091G06OS.
TreeFamiTF300342.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
InterProiView protein in InterPro
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
PfamiView protein in Pfam
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiView protein in PROSITE
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3U4X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKEQERKG ETSAANMQRS IMSFFQPTKE GKAKKPEKET PSSIREKEPP
60 70 80 90 100
PKVALKERNQ VVPESDSPVK RTGRKVAQVL SCEGEDEDEA PGTPKVQKPV
110 120 130 140 150
SDSEQSSPPS PDTCPENSPV FNCSSPMDIS PSGFPKRRTA RKQLPKRTIQ
160 170 180 190 200
DTLEEQNEDK TKTAKKRKKE EETPKESLAE AEDVKQKEEK EGDQLIVPSE
210 220 230 240 250
PTKSPESVTL TKTENIPVCK AGVKLKPQEE EQSKPPARGA KTLSSFFTPR
260 270 280 290 300
KPAVKTEVKQ EESGTLRKEE TKGTLDPANY NPSKNNYHPI EDACWKHGQK
310 320 330 340 350
VPFLAVARTF EKIEEVSARL KMVETLSNLL RSVVALSPPD LLPVLYLSLN
360 370 380 390 400
RLGPPQQGLE LGVGDGVLLK AVAQATGRQL ESIRAEVAEK GDVGLVAENS
410 420 430 440 450
RSTQRLMLPP PPLTISGVFT KFCDIARLTG SASMAKKMDI IKGLFVACRH
460 470 480 490 500
SEARYIARSL SGRLRLGLAE QSVLAALAQA VSLTPPGQEF PTAVVDAGKG
510 520 530 540 550
KTAEARKMWL EEQGMILKQT FCEVPDLDRI IPVLLEHGLE RLPEHCKLSP
560 570 580 590 600
GVPLKPMLAH PTRGVSEVLK RFEEVDFTCE YKYDGQRAQI HVLEGGEVKI
610 620 630 640 650
FSRNQEDNTG KYPDIISRIP KIKHPSVTSF ILDTEAVAWD REKKQIQPFQ
660 670 680 690 700
VLTTRKRKEV DASEIQVQVC LYAFDLIYLN GESLVRQPLS RRRQLLRENF
710 720 730 740 750
VETEGEFVFT TSLDTKDTEQ IAEFLEQSVK DSCEGLMVKT LDVDATYEIA
760 770 780 790 800
KRSHNWLKLK KDYLDGVGDT LDLVVIGAYL GRGKRAGRYG GFLLAAYDEE
810 820 830 840 850
SEELQAICKL GTGFSDEELE EHHQSLQALV LPTPRPYVRI DGAVAPDHWL
860 870 880 890 900
DPSIVWEVKC ADLSLSPIYP AARGLVDKEK GISLRFPRFI RVRKDKQPEQ
910 920 930
ATTSNQVASL YRKQSQIQNQ QSSDLDSDVE DY
Length:932
Mass (Da):104,093
Last modified:October 11, 2005 - v1
Checksum:iBAC3966B2D3D523A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161792 Genomic DNA. No translation available.
BC138541 mRNA. Translation: AAI38542.1.
BC138542 mRNA. Translation: AAI38543.1.
AK153993 mRNA. Translation: BAE32302.1.
RefSeqiNP_001076657.1. NM_001083188.1.
NP_001186239.1. NM_001199310.1.
NP_034845.2. NM_010715.2.
UniGeneiMm.288179.
Mm.421129.

Genome annotation databases

EnsembliENSMUST00000098814; ENSMUSP00000096411; ENSMUSG00000056394.
ENSMUST00000165964; ENSMUSP00000126525; ENSMUSG00000056394.
ENSMUST00000177588; ENSMUSP00000136972; ENSMUSG00000056394.
GeneIDi16881.
KEGGimmu:16881.
UCSCiuc009ffq.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3U4X8_MOUSE
AccessioniPrimary (citable) accession number: Q3U4X8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported