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Q3U4W8

- Q3U4W8_MOUSE

UniProt

Q3U4W8 - Q3U4W8_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Usp5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei209 – 2091SubstrateUniRule annotation
    Binding sitei259 – 2591SubstrateUniRule annotation
    Binding sitei261 – 2611Substrate; via carbonyl oxygenUniRule annotation
    Binding sitei264 – 2641SubstrateUniRule annotation
    Active sitei335 – 3351NucleophileUniRule annotation
    Active sitei795 – 7951Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. omega peptidase activity Source: InterPro
    3. protein binding Source: MGI
    4. ubiquitinyl hydrolase activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
    Gene namesi
    Name:Usp5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1347343. Usp5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3U4W8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni221 – 2244Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the peptidase C19 family.UniRule annotation
    Contains USP domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000000874.
    HOGENOMiHOG000162311.
    HOVERGENiHBG002833.
    KOiK11836.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00627. UBA. 2 hits.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016308. UBP. 1 hit.
    SMARTiSM00165. UBA. 2 hits.
    SM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    PROSITEiPS50030. UBA. 2 hits.
    PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3U4W8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF    50
    LGFGKQYVER HFNKTGQRVY LHLRRTRRPK EEDTSAGTGD PPRKKPTRLA 100
    IGVEGGFDLT EDKFEFDEDV KIVILPDYLE IARDGLGGLP DIVRDRVTSA 150
    VEALLSADSA SRKQEVQAWD GEVRQVSKHA FNLKQLDNPA RIPPCGWKCS 200
    KCDMRENLWL NLTDGSILCG RRYFDGSGGN NHAVEHYRET GYPLAVKLGT 250
    ITPDGADVYS YDEDDMVLDP SLAEHLSHFG IDMLKMQKTD KTMTELEIDM 300
    NQRIGEWELI QESGVPLKPL FGPGYTGIRN LGNSCYLNSV VQVLFSIPDF 350
    QRKYVDKLEK IFQNAPTDPT QDFSTQVAKL GHGLLSGEYS KPALESGDGE 400
    QVPEQKEVQD GIAPRMFKAL IGKGHPEFST NRQQDAQEFF LHLINMVERN 450
    CRSSENPNEV FRFLVEEKIK CLATEKVKYT QRVDYIMQLP VPMDAALNKE 500
    ELLEYEEKKR QAEEEKVPLP ELVRAQVPFS SCLEAYGAPE QVDDFWSTAL 550
    QAKSVAVKTT RFASFPDYLV IQIKKFTFGL DWVPKKLDVS IEMPEELDIS 600
    QLRGTGLQPG EEELPDIAPP LVTPDEPKAP MLDESVIIQL VEMGFPMDAC 650
    RKAVYYTGNS GAEAAMNWVM SHMDDPDFAN PLILPGSSGP GSTSAAADPP 700
    PEDCVTTIVS MGFSRDQALK ALRATNNSLE RAVDWIFSHI DDLDAEAAMD 750
    ISEGRSAAES ISESVPVGPK VRDGPGKYQL FAFISHMGTS TMCGHYVCHI 800
    KKEGRWVIYN DQKVCASEKP PKDLGYIYFY QRVVS 835
    Length:835
    Mass (Da):93,355
    Last modified:October 11, 2005 - v1
    Checksum:iE7E920647E8CB9AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142254 Genomic DNA. No translation available.
    AK154008 mRNA. Translation: BAE32312.1.
    RefSeqiXP_006505978.1. XM_006505915.1.
    UniGeneiMm.3571.

    Genome annotation databases

    EnsembliENSMUST00000122110; ENSMUSP00000114000; ENSMUSG00000038429.
    GeneIDi22225.
    KEGGimmu:22225.
    UCSCiuc009dsb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142254 Genomic DNA. No translation available.
    AK154008 mRNA. Translation: BAE32312.1 .
    RefSeqi XP_006505978.1. XM_006505915.1.
    UniGenei Mm.3571.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000122110 ; ENSMUSP00000114000 ; ENSMUSG00000038429 .
    GeneIDi 22225.
    KEGGi mmu:22225.
    UCSCi uc009dsb.1. mouse.

    Organism-specific databases

    CTDi 8078.
    MGIi MGI:1347343. Usp5.

    Phylogenomic databases

    GeneTreei ENSGT00390000000874.
    HOGENOMi HOG000162311.
    HOVERGENi HBG002833.
    KOi K11836.

    Miscellaneous databases

    ChiTaRSi USP5. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3U4W8.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00627. UBA. 2 hits.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016308. UBP. 1 hit.
    SMARTi SM00165. UBA. 2 hits.
    SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    PROSITEi PS50030. UBA. 2 hits.
    PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: ThymusImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    11. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3U4W8_MOUSE
    AccessioniPrimary (citable) accession number: Q3U4W8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3