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Protein

IGF-like family receptor 1

Gene

Igflr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable cell membrane receptor for the IGF-like family protein IGFL.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
IGF-like family receptor 1
Alternative name(s):
Transmembrane protein 149
Gene namesi
Name:Igflr1
Synonyms:Tmem149
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3655979. Igflr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 163ExtracellularSequence analysisAdd BLAST143
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 345CytoplasmicSequence analysisAdd BLAST161

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000029035821 – 345IGF-like family receptor 1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3U4N7.
PRIDEiQ3U4N7.

PTM databases

PhosphoSitePlusiQ3U4N7.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lymph node. Highly expressed in T-cells and monocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000036826.
CleanExiMM_TMEM149.
MM_U2AF1L4.
ExpressionAtlasiQ3U4N7. differential.
GenevisibleiQ3U4N7. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IgflQ6B9Z03EBI-3870498,EBI-3870418

Protein-protein interaction databases

IntActiQ3U4N7. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ3U4N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJZ. Eukaryota.
ENOG410YY5D. LUCA.
GeneTreeiENSGT00390000005702.
HOVERGENiHBG099100.
InParanoidiQ3U4N7.
PhylomeDBiQ3U4N7.
TreeFamiTF338761.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U4N7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPSWLLWTV AVAVLLLTRA ASMEASSFCG HLEYWNSDKR CCSRCLQRFG
60 70 80 90 100
PPACPDHEFT ENCGLNDFGD TVAHPFKKCS PGYCNPNGTE LCSQCSSGAA
110 120 130 140 150
AAPAHVESPG RTHKQCRKKP VPPKDVCPLK PEDAGASSSP GRWSLGQTTK
160 170 180 190 200
NEVSSRPGFV SASVLPLAVL PLLLVLLLIL AVVLLSLFKR KVRSRPGSSS
210 220 230 240 250
AFGDPSTSLH YWPCPGTLEV LESRNRGKAN LLQLSSWELQ GLASQPLSLL
260 270 280 290 300
LDELEVLEEL IMLLDPEPGP SGSTAYGTTR HLAARYGLPA TWSTFAYSLR
310 320 330 340
PSRSPLRALI EMVVAREPSA TLGQFGTYLA QLGRTDALQV LSKLG
Length:345
Mass (Da):37,172
Last modified:October 11, 2005 - v1
Checksum:iB66AF0D33849BE9A
GO
Isoform 2 (identifier: Q3U4N7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):37,044
Checksum:iB9A45D2AD1383D7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156R → Q in AAH19733 (PubMed:15489334).Curated1
Sequence conflicti197G → S in AAH19733 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026146118Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154129 mRNA. Translation: BAE32394.1.
BC019733 mRNA. Translation: AAH19733.1.
CCDSiCCDS39886.1. [Q3U4N7-1]
RefSeqiNP_663555.2. NM_145580.2. [Q3U4N7-1]
UniGeneiMm.333757.

Genome annotation databases

EnsembliENSMUST00000043850; ENSMUSP00000042312; ENSMUSG00000036826. [Q3U4N7-1]
GeneIDi101883.
KEGGimmu:101883.
UCSCiuc009gfb.1. mouse. [Q3U4N7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154129 mRNA. Translation: BAE32394.1.
BC019733 mRNA. Translation: AAH19733.1.
CCDSiCCDS39886.1. [Q3U4N7-1]
RefSeqiNP_663555.2. NM_145580.2. [Q3U4N7-1]
UniGeneiMm.333757.

3D structure databases

ProteinModelPortaliQ3U4N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3U4N7. 1 interactor.

PTM databases

PhosphoSitePlusiQ3U4N7.

Proteomic databases

PaxDbiQ3U4N7.
PRIDEiQ3U4N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043850; ENSMUSP00000042312; ENSMUSG00000036826. [Q3U4N7-1]
GeneIDi101883.
KEGGimmu:101883.
UCSCiuc009gfb.1. mouse. [Q3U4N7-1]

Organism-specific databases

CTDi79713.
MGIiMGI:3655979. Igflr1.

Phylogenomic databases

eggNOGiENOG410IKJZ. Eukaryota.
ENOG410YY5D. LUCA.
GeneTreeiENSGT00390000005702.
HOVERGENiHBG099100.
InParanoidiQ3U4N7.
PhylomeDBiQ3U4N7.
TreeFamiTF338761.

Miscellaneous databases

PROiQ3U4N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036826.
CleanExiMM_TMEM149.
MM_U2AF1L4.
ExpressionAtlasiQ3U4N7. differential.
GenevisibleiQ3U4N7. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIGFR1_MOUSE
AccessioniPrimary (citable) accession number: Q3U4N7
Secondary accession number(s): Q8VE58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.