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Q3U4C5 (Q3U4C5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Adenosine receptor A3 RuleBase RU201114
Gene names
Name:Adora3 EMBL EDL07541.1 MGI 104847 Ensembl ENSMUSP00000000574
ORF Names:mCG_10744 EMBL EDL07541.1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase By similarity. RuleBase RU201114

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU201114

Caution

Lacks conserved residue(s) required for the propagation of feature annotation. RuleBase RU201114

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix RuleBase RU201114
   Molecular functionG-protein coupled receptor RuleBase RU201114
Receptor
Transducer
   PTMDisulfide bond RuleBase RU201114
Glycoprotein RuleBase RU201114
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenosine receptor signaling pathway

Inferred from mutant phenotype PubMed 12817016. Source: MGI

histamine secretion by mast cell

Inferred from direct assay PubMed 12817016. Source: MGI

positive regulation of calcium-mediated signaling

Inferred from direct assay PubMed 12817016. Source: MGI

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 15240734. Source: MGI

positive regulation of leukocyte migration

Inferred from mutant phenotype PubMed 15240734. Source: MGI

positive regulation of mast cell degranulation

Inferred from direct assay PubMed 12817016. Source: MGI

positive regulation of mucus secretion

Inferred from mutant phenotype PubMed 15240734. Source: MGI

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 12817016. Source: MGI

   Cellular_componentintegral component of plasma membrane

Inferred from mutant phenotype PubMed 10660615. Source: MGI

mast cell granule

Inferred from direct assay PubMed 12817016. Source: GOC

plasma membrane

Inferred from direct assay PubMed 12817016. Source: MGI

   Molecular_functionG-protein coupled adenosine receptor activity

Inferred from direct assay PubMed 12817016. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q3U4C5 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: F771EBA37DC9286E

FASTA31936,435
        10         20         30         40         50         60 
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTFY FIVSLALADI 

        70         80         90        100        110        120 
AVGVLVTPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM SLLAIAVDRY LRVKLTVRYR 

       130        140        150        160        170        180 
TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW NRKATLASSQ NSSTLLCHFR SVVSLDYMVF 

       190        200        210        220        230        240 
FSFVTWILVP LVVMCVIYLD IFYIIRNKLS QNLSGFRETR AFYGREFKTA KSLFLVLFLF 

       250        260        270        280        290        300 
ALCWLPLSII NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA 

       310 
LRLCQTSDSL DSNMEQTTE 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[6]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL07541.1.
[7]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE32507.1.
[10]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL07541.1.
[11]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000000574.
[12]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000000574.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC121847 Genomic DNA. No translation available.
AK154312 mRNA. Translation: BAE32507.1.
CH466608 Genomic DNA. Translation: EDL07541.1.
RefSeqNP_033761.2. NM_009631.4.
UniGeneMm.235024.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

DNASU11542.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000574; ENSMUSP00000000574; ENSMUSG00000000562.
GeneID11542.
KEGGmmu:11542.
UCSCuc008qvi.1. mouse.

Organism-specific databases

CTD140.
MGIMGI:104847. Adora3.

Phylogenomic databases

GeneTreeENSGT00550000074524.
HOVERGENHBG106962.
InParanoidQ3U4C5.
KOK04268.
OMASHANSMM.
OrthoDBEOG79SDXQ.
TreeFamTF325296.

Gene expression databases

GenevestigatorQ3U4C5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279008.
SOURCESearch...

Entry information

Entry nameQ3U4C5_MOUSE
AccessionPrimary (citable) accession number: Q3U4C5
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)