Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosine receptor A3

Gene

Adora3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973 Adenosine P1 receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3UniRule annotation
Gene namesi
Name:Adora3Imported
ORF Names:mCG_10744Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:104847 Adora3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 37HelicalUniRule annotationAdd BLAST24
Transmembranei49 – 73HelicalUniRule annotationAdd BLAST25
Transmembranei79 – 107HelicalUniRule annotationAdd BLAST29
Transmembranei128 – 150HelicalUniRule annotationAdd BLAST23
Transmembranei179 – 205HelicalUniRule annotationAdd BLAST27
Transmembranei233 – 256HelicalUniRule annotationAdd BLAST24
Transmembranei262 – 285HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000562

Structurei

3D structure databases

SMRiQ3U4C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 283G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOVERGENiHBG106962
KOiK04268
OMAiMRMDYMV
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR000466 Adeno_A3_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00555 ADENOSINEA3R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3U4C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTFY
60 70 80 90 100
FIVSLALADI AVGVLVTPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM
110 120 130 140 150
SLLAIAVDRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW
160 170 180 190 200
NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFVTWILVP LVVMCVIYLD
210 220 230 240 250
IFYIIRNKLS QNLSGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII
260 270 280 290 300
NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA
310
LRLCQTSDSL DSNMEQTTE
Length:319
Mass (Da):36,435
Last modified:October 11, 2005 - v1
Checksum:iF771EBA37DC9286E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121847 Genomic DNA No translation available.
AK154312 mRNA Translation: BAE32507.1
CH466608 Genomic DNA Translation: EDL07541.1
RefSeqiNP_033761.2, NM_009631.4
UniGeneiMm.235024

Genome annotation databases

EnsembliENSMUST00000000574; ENSMUSP00000000574; ENSMUSG00000000562
GeneIDi11542
KEGGimmu:11542
UCSCiuc008qvi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3U4C5_MOUSE
AccessioniPrimary (citable) accession number: Q3U4C5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health