Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3U4C5

- Q3U4C5_MOUSE

UniProt

Q3U4C5 - Q3U4C5_MOUSE

Protein

Adenosine receptor A3

Gene

Adora3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.UniRule annotation

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: MGI

    GO - Biological processi

    1. adenosine receptor signaling pathway Source: MGI
    2. histamine secretion by mast cell Source: MGI
    3. positive regulation of calcium-mediated signaling Source: MGI
    4. positive regulation of inflammatory response Source: MGI
    5. positive regulation of leukocyte migration Source: MGI
    6. positive regulation of mast cell degranulation Source: MGI
    7. positive regulation of mucus secretion Source: MGI
    8. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A3UniRule annotation
    Gene namesi
    Name:Adora3Imported
    ORF Names:mCG_10744Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:104847. Adora3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. mast cell granule Source: GOC
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ3U4C5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074524.
    HOVERGENiHBG106962.
    InParanoidiQ3U4C5.
    KOiK04268.
    OMAiSHANSMM.
    OrthoDBiEOG79SDXQ.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000466. Adeno_A3_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00555. ADENOSINEA3R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3U4C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTFY    50
    FIVSLALADI AVGVLVTPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM 100
    SLLAIAVDRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW 150
    NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFVTWILVP LVVMCVIYLD 200
    IFYIIRNKLS QNLSGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII 250
    NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA 300
    LRLCQTSDSL DSNMEQTTE 319
    Length:319
    Mass (Da):36,435
    Last modified:October 11, 2005 - v1
    Checksum:iF771EBA37DC9286E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC121847 Genomic DNA. No translation available.
    AK154312 mRNA. Translation: BAE32507.1.
    CH466608 Genomic DNA. Translation: EDL07541.1.
    RefSeqiNP_033761.2. NM_009631.4.
    UniGeneiMm.235024.

    Genome annotation databases

    EnsembliENSMUST00000000574; ENSMUSP00000000574; ENSMUSG00000000562.
    GeneIDi11542.
    KEGGimmu:11542.
    UCSCiuc008qvi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC121847 Genomic DNA. No translation available.
    AK154312 mRNA. Translation: BAE32507.1 .
    CH466608 Genomic DNA. Translation: EDL07541.1 .
    RefSeqi NP_033761.2. NM_009631.4.
    UniGenei Mm.235024.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    DNASUi 11542.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000574 ; ENSMUSP00000000574 ; ENSMUSG00000000562 .
    GeneIDi 11542.
    KEGGi mmu:11542.
    UCSCi uc008qvi.1. mouse.

    Organism-specific databases

    CTDi 140.
    MGIi MGI:104847. Adora3.

    Phylogenomic databases

    GeneTreei ENSGT00550000074524.
    HOVERGENi HBG106962.
    InParanoidi Q3U4C5.
    KOi K04268.
    OMAi SHANSMM.
    OrthoDBi EOG79SDXQ.
    TreeFami TF325296.

    Miscellaneous databases

    NextBioi 279008.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3U4C5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000466. Adeno_A3_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00555. ADENOSINEA3R.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    12. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3U4C5_MOUSE
    AccessioniPrimary (citable) accession number: Q3U4C5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3