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Q3U4C5

- Q3U4C5_MOUSE

UniProt

Q3U4C5 - Q3U4C5_MOUSE

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Protein

Adenosine receptor A3

Gene

Adora3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.UniRule annotation

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  1. adenosine receptor signaling pathway Source: MGI
  2. histamine secretion by mast cell Source: MGI
  3. positive regulation of calcium-mediated signaling Source: MGI
  4. positive regulation of inflammatory response Source: MGI
  5. positive regulation of leukocyte migration Source: MGI
  6. positive regulation of mast cell degranulation Source: MGI
  7. positive regulation of mucus secretion Source: MGI
  8. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3UniRule annotation
Gene namesi
Name:Adora3Imported
ORF Names:mCG_10744Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:104847. Adora3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. mast cell granule Source: GOC
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation, GlycoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ3U4C5.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074524.
HOVERGENiHBG106962.
KOiK04268.
OMAiSHANSMM.
OrthoDBiEOG79SDXQ.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U4C5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADNTTETD WLNITYITME AAIGLCAVVG NMLVIWVVKL NPTLRTTTFY
60 70 80 90 100
FIVSLALADI AVGVLVTPLA IAVSLQVKMH FYACLFMSCV LLIFTHASIM
110 120 130 140 150
SLLAIAVDRY LRVKLTVRYR TVTTQRRIWL FLGLCWLVSF LVGLTPMFGW
160 170 180 190 200
NRKATLASSQ NSSTLLCHFR SVVSLDYMVF FSFVTWILVP LVVMCVIYLD
210 220 230 240 250
IFYIIRNKLS QNLSGFRETR AFYGREFKTA KSLFLVLFLF ALCWLPLSII
260 270 280 290 300
NFVSYFDVKI PDVAMCLGIL LSHANSMMNP IVYACKIKKF KETYFLILRA
310
LRLCQTSDSL DSNMEQTTE
Length:319
Mass (Da):36,435
Last modified:October 11, 2005 - v1
Checksum:iF771EBA37DC9286E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC121847 Genomic DNA. No translation available.
AK154312 mRNA. Translation: BAE32507.1.
CH466608 Genomic DNA. Translation: EDL07541.1.
RefSeqiNP_033761.2. NM_009631.4.
UniGeneiMm.235024.

Genome annotation databases

EnsembliENSMUST00000000574; ENSMUSP00000000574; ENSMUSG00000000562.
GeneIDi11542.
KEGGimmu:11542.
UCSCiuc008qvi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC121847 Genomic DNA. No translation available.
AK154312 mRNA. Translation: BAE32507.1 .
CH466608 Genomic DNA. Translation: EDL07541.1 .
RefSeqi NP_033761.2. NM_009631.4.
UniGenei Mm.235024.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

DNASUi 11542.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000574 ; ENSMUSP00000000574 ; ENSMUSG00000000562 .
GeneIDi 11542.
KEGGi mmu:11542.
UCSCi uc008qvi.1. mouse.

Organism-specific databases

CTDi 140.
MGIi MGI:104847. Adora3.

Phylogenomic databases

GeneTreei ENSGT00550000074524.
HOVERGENi HBG106962.
KOi K04268.
OMAi SHANSMM.
OrthoDBi EOG79SDXQ.
TreeFami TF325296.

Miscellaneous databases

NextBioi 279008.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3U4C5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3U4C5_MOUSE
AccessioniPrimary (citable) accession number: Q3U4C5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3