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Q3U492

- KCP_MOUSE

UniProt

Q3U492 - KCP_MOUSE

Protein

Kielin/chordin-like protein

Gene

Kcp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. hematopoietic progenitor cell differentiation Source: MGI
    2. positive regulation of BMP signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kielin/chordin-like protein
    Alternative name(s):
    Cysteine-rich BMP regulator 2
    Cysteine-rich motor neuron 2 protein
    Short name:
    CRIM-2
    Kielin/chordin-like protein 1
    Short name:
    KCP-1
    Gene namesi
    Name:Kcp
    Synonyms:Crim2, Kcp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2141640. Kcp.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 15501529Kielin/chordin-like proteinPRO_0000318587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1236 ↔ 1244PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ3U492.

    Expressioni

    Tissue specificityi

    Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines.1 Publication

    Developmental stagei

    Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At E9.5 the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as E9 in the intermediate mesoderm. By E10, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At E18.5, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone.1 Publication

    Inductioni

    By renal stresses.1 Publication

    Gene expression databases

    BgeeiQ3U492.
    CleanExiMM_CRIM2.
    GenevestigatoriQ3U492.

    Interactioni

    Subunit structurei

    Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.2 Publications

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000099135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini134 – 19158VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 25160VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini253 – 31260VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini313 – 37058VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini371 – 42555VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini426 – 48560VWFC 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini486 – 54459VWFC 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini545 – 60258VWFC 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini603 – 66159VWFC 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini665 – 72460VWFC 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini725 – 78157VWFC 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini782 – 84059VWFC 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini841 – 90262VWFC 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini903 – 95856VWFC 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini959 – 101658VWFC 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini1017 – 108468VWFC 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini1085 – 114460VWFC 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1148 – 120861VWFC 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini1213 – 1425213VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini1489 – 154254TILAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili60 – 9233Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 18 VWFC domains.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG283828.
    GeneTreeiENSGT00730000110288.
    HOGENOMiHOG000168484.
    InParanoidiQ3U492.
    OMAiLVGCPPS.
    TreeFamiTF106451.

    Family and domain databases

    InterProiIPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF00093. VWC. 9 hits.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00832. C8. 1 hit.
    SM00214. VWC. 17 hits.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 1 hit.
    PROSITEiPS01208. VWFC_1. 13 hits.
    PS50184. VWFC_2. 14 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3U492-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGARAALLP LLLHLGSLAL AARGGEVSRE QPRLADAISQ QQAPSHSLVP     50
    GETHQQQWCP LEERLERLEA EVTDLRKQNR ELQARVVQLE SCECWGPGHT 100
    CPEGARWEPD ACTACVCRDG TAHCGPQPNL PHCRGCSHNG QSYGHGETFS 150
    PDACTTCRCL AGTVQCQGPS CSELNCLESF IPPGECCPIC RPGCEYEGQL 200
    HQEGSSFLSS SNPCLQCSCL RSLVRCVPVK CQPSPCLNPV PRLGHCCPVC 250
    QASGCTEGNS HRDHGQEWTT PGDPCRICQC LEGHIQCRQR ECASLCPYPA 300
    RPLPGTCCPV CDGCFLNGRE HSSGEPVGSQ DPCSSCRCTN GSVQCEPLPC 350
    PPAPCRYPGR IPGQCCPVCD GCKYQGHEYR SQETFTLQEN GRCLRCVCQA 400
    GEVSCEEQDC PVTPCVRSAS GPQLCSACVL NGEEFAEGIQ WEPDDQPCTS 450
    CSCQDGVPVC RAVLCSPVPC QHPTQPPGAC CPSCDSCTYH SLVYANGQNF 500
    TDVDSPCQTC YCEDGTVRCS LINCPFTTCA KPQNGPGQCC PKCPDCILEA 550
    QVFVDGERFP HPRDPCQECW CQEGQAHCQL RACPSAPCVH PLPGTCCKND 600
    CTGCAFGGKE YPNGADFPHP TDPCRLCRCL SGNVQCLARR CPPLSCPQPV 650
    LTPGDCCPQC PDAPADCPQS GNMVPVRHQE HFFQPGDPCS RCLCLDGSVS 700
    CQRLTCPPAP CAHPRRDACC PSCDGCLYQG KEFASGERFP SPNVACHVCL 750
    CWEGSVKCEP RTCAPAQCPF PTREDCCPAC DSCDYLGVSY LSSQEFPDPR 800
    EACNLCTCLG GFVTCTRRPC EPPACSHPLI VPEHCCPTCQ GCLYHGITAA 850
    LGETLPDPLD PTCSLCTCEE GSMRCQKKPC PPAPCAHPSP GPCFCPVCRS 900
    CLSQGREHQD GEEFEGPEGS CERCRCLAGQ VSCTRLQCPS LPCLHQVTEP 950
    GTCCPRCTGC LARGEEHPEG SSWVPADSPC SSCMCHKGII TCAQVQCVSA 1000
    CIWPQEGPSD CCPQCSGCEH GGRKYEPGES FQPGADPCEV CICKQKREGP 1050
    PSLHCSRRQC PSLVGCPPSQ LLPPGPQHCC PTCAQALSNC TEDLVGSELV 1100
    PPDPCYTCQC QDLTWLCTHR ACPELSCPLW ERHTTPGSCC PVCKDPTQSC 1150
    MHQGRWVASG EQWAVDACTS CSCVAGTVHC QTQRCRKLAC SRDEVPALSP 1200
    GSCCLRCLPR PASCMAFGDP HYRTFDGRLL HFQGSCSYVL AKDCHGEDFS 1250
    VHVTNDDRGR RGVAWTQEVA VLLGTVAVRL LQGRTVMVDQ HTVTLPFLRE 1300
    PLLYIELRGH TVILHAQPGL QVLWDGQSQV EVRVPSSYRG QTCGLCGNFN 1350
    GFAQDDLQGP DGRLLPTEAS FGNSWKVPKG LGPGRPCSAG REVDPCRAAG 1400
    YRARREANAR CGILKTSPFS HCHAVVPPEP FFAACVYDLC ACGPGSSSDT 1450
    CLCDALEAYA SHCRQAGVTP VWRGPTLCVV GCPVDRGFVF DECGPPCPRT 1500
    CFNRHIPLGE LAAHCVRPCV PGCQCPAGLV EHEGHCISPE VCPPVLLTGD 1550
    Length:1,550
    Mass (Da):166,628
    Last modified:July 27, 2011 - v2
    Checksum:i6E6630EDA239D744
    GO
    Isoform 2 (identifier: Q3U492-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1250-1255: SVHVTN → RWTSTQ
         1256-1550: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,255
    Mass (Da):135,115
    Checksum:i01A83D89AB0109E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti385 – 3851F → L in AAX77677. (PubMed:15793581)Curated
    Sequence conflicti829 – 8291L → F in BAE32541. (PubMed:16141072)Curated
    Sequence conflicti1045 – 10451Missing in AAX77677. (PubMed:15793581)Curated
    Sequence conflicti1147 – 11471T → N in BAE32541. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1250 – 12556SVHVTN → RWTSTQ in isoform 2. 1 PublicationVSP_031232
    Alternative sequencei1256 – 1550295Missing in isoform 2. 1 PublicationVSP_031233Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY884211 mRNA. Translation: AAX77677.1.
    AK154369 mRNA. Translation: BAE32541.1.
    AC079276 Genomic DNA. No translation available.
    CCDSiCCDS57415.1. [Q3U492-1]
    RefSeqiNP_001025156.3. NM_001029985.4. [Q3U492-1]
    UniGeneiMm.332961.

    Genome annotation databases

    EnsembliENSMUST00000078112; ENSMUSP00000077251; ENSMUSG00000059022. [Q3U492-2]
    ENSMUST00000101614; ENSMUSP00000099135; ENSMUSG00000059022. [Q3U492-1]
    GeneIDi333088.
    KEGGimmu:333088.
    UCSCiuc009bdt.2. mouse. [Q3U492-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY884211 mRNA. Translation: AAX77677.1 .
    AK154369 mRNA. Translation: BAE32541.1 .
    AC079276 Genomic DNA. No translation available.
    CCDSi CCDS57415.1. [Q3U492-1 ]
    RefSeqi NP_001025156.3. NM_001029985.4. [Q3U492-1 ]
    UniGenei Mm.332961.

    3D structure databases

    ProteinModelPortali Q3U492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000099135.

    Proteomic databases

    PRIDEi Q3U492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078112 ; ENSMUSP00000077251 ; ENSMUSG00000059022 . [Q3U492-2 ]
    ENSMUST00000101614 ; ENSMUSP00000099135 ; ENSMUSG00000059022 . [Q3U492-1 ]
    GeneIDi 333088.
    KEGGi mmu:333088.
    UCSCi uc009bdt.2. mouse. [Q3U492-1 ]

    Organism-specific databases

    CTDi 375616.
    MGIi MGI:2141640. Kcp.

    Phylogenomic databases

    eggNOGi NOG283828.
    GeneTreei ENSGT00730000110288.
    HOGENOMi HOG000168484.
    InParanoidi Q3U492.
    OMAi LVGCPPS.
    TreeFami TF106451.

    Miscellaneous databases

    NextBioi 399938.
    PROi Q3U492.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3U492.
    CleanExi MM_CRIM2.
    Genevestigatori Q3U492.

    Family and domain databases

    InterProi IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF00093. VWC. 9 hits.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00832. C8. 1 hit.
    SM00214. VWC. 17 hits.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 1 hit.
    PROSITEi PS01208. VWFC_1. 13 hits.
    PS50184. VWFC_2. 14 hits.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease."
      Lin J., Patel S.R., Cheng X., Cho E.A., Levitan I., Ullenbruch M., Phan S.H., Park J.M., Dressler G.R.
      Nat. Med. 11:387-393(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH BMP7, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INDUCTION BY RENAL STRESSES.
      Strain: FVB/N.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: NOD.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia."
      Lin J., Patel S.R., Wang M., Dressler G.R.
      Mol. Cell. Biol. 26:4577-4585(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ACTIVIN A AND TGFB1.

    Entry informationi

    Entry nameiKCP_MOUSE
    AccessioniPrimary (citable) accession number: Q3U492
    Secondary accession number(s): E9QJU0, Q56NI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3