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Q3U492

- KCP_MOUSE

UniProt

Q3U492 - KCP_MOUSE

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Protein

Kielin/chordin-like protein

Gene
Kcp, Crim2, Kcp1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: MGI
  2. positive regulation of BMP signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
Gene namesi
Name:Kcp
Synonyms:Crim2, Kcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2141640. Kcp.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 15501529Kielin/chordin-like proteinPRO_0000318587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1236 ↔ 1244 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ3U492.

Expressioni

Tissue specificityi

Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines.1 Publication

Developmental stagei

Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At E9.5 the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as E9 in the intermediate mesoderm. By E10, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At E18.5, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone.1 Publication

Inductioni

By renal stresses.1 Publication

Gene expression databases

BgeeiQ3U492.
CleanExiMM_CRIM2.
GenevestigatoriQ3U492.

Interactioni

Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099135.

Structurei

3D structure databases

ProteinModelPortaliQ3U492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 19158VWFC 1Add
BLAST
Domaini192 – 25160VWFC 2Add
BLAST
Domaini253 – 31260VWFC 3Add
BLAST
Domaini313 – 37058VWFC 4Add
BLAST
Domaini371 – 42555VWFC 5Add
BLAST
Domaini426 – 48560VWFC 6Add
BLAST
Domaini486 – 54459VWFC 7Add
BLAST
Domaini545 – 60258VWFC 8Add
BLAST
Domaini603 – 66159VWFC 9Add
BLAST
Domaini665 – 72460VWFC 10Add
BLAST
Domaini725 – 78157VWFC 11Add
BLAST
Domaini782 – 84059VWFC 12Add
BLAST
Domaini841 – 90262VWFC 13Add
BLAST
Domaini903 – 95856VWFC 14Add
BLAST
Domaini959 – 101658VWFC 15Add
BLAST
Domaini1017 – 108468VWFC 16Add
BLAST
Domaini1085 – 114460VWFC 17Add
BLAST
Domaini1148 – 120861VWFC 18Add
BLAST
Domaini1213 – 1425213VWFDAdd
BLAST
Domaini1489 – 154254TILAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 9233 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 18 VWFC domains.
Contains 1 VWFD domain.

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00730000110288.
HOGENOMiHOG000168484.
InParanoidiQ3U492.
OMAiLVGCPPS.
TreeFamiTF106451.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 9 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 17 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 13 hits.
PS50184. VWFC_2. 14 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3U492-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGARAALLP LLLHLGSLAL AARGGEVSRE QPRLADAISQ QQAPSHSLVP     50
GETHQQQWCP LEERLERLEA EVTDLRKQNR ELQARVVQLE SCECWGPGHT 100
CPEGARWEPD ACTACVCRDG TAHCGPQPNL PHCRGCSHNG QSYGHGETFS 150
PDACTTCRCL AGTVQCQGPS CSELNCLESF IPPGECCPIC RPGCEYEGQL 200
HQEGSSFLSS SNPCLQCSCL RSLVRCVPVK CQPSPCLNPV PRLGHCCPVC 250
QASGCTEGNS HRDHGQEWTT PGDPCRICQC LEGHIQCRQR ECASLCPYPA 300
RPLPGTCCPV CDGCFLNGRE HSSGEPVGSQ DPCSSCRCTN GSVQCEPLPC 350
PPAPCRYPGR IPGQCCPVCD GCKYQGHEYR SQETFTLQEN GRCLRCVCQA 400
GEVSCEEQDC PVTPCVRSAS GPQLCSACVL NGEEFAEGIQ WEPDDQPCTS 450
CSCQDGVPVC RAVLCSPVPC QHPTQPPGAC CPSCDSCTYH SLVYANGQNF 500
TDVDSPCQTC YCEDGTVRCS LINCPFTTCA KPQNGPGQCC PKCPDCILEA 550
QVFVDGERFP HPRDPCQECW CQEGQAHCQL RACPSAPCVH PLPGTCCKND 600
CTGCAFGGKE YPNGADFPHP TDPCRLCRCL SGNVQCLARR CPPLSCPQPV 650
LTPGDCCPQC PDAPADCPQS GNMVPVRHQE HFFQPGDPCS RCLCLDGSVS 700
CQRLTCPPAP CAHPRRDACC PSCDGCLYQG KEFASGERFP SPNVACHVCL 750
CWEGSVKCEP RTCAPAQCPF PTREDCCPAC DSCDYLGVSY LSSQEFPDPR 800
EACNLCTCLG GFVTCTRRPC EPPACSHPLI VPEHCCPTCQ GCLYHGITAA 850
LGETLPDPLD PTCSLCTCEE GSMRCQKKPC PPAPCAHPSP GPCFCPVCRS 900
CLSQGREHQD GEEFEGPEGS CERCRCLAGQ VSCTRLQCPS LPCLHQVTEP 950
GTCCPRCTGC LARGEEHPEG SSWVPADSPC SSCMCHKGII TCAQVQCVSA 1000
CIWPQEGPSD CCPQCSGCEH GGRKYEPGES FQPGADPCEV CICKQKREGP 1050
PSLHCSRRQC PSLVGCPPSQ LLPPGPQHCC PTCAQALSNC TEDLVGSELV 1100
PPDPCYTCQC QDLTWLCTHR ACPELSCPLW ERHTTPGSCC PVCKDPTQSC 1150
MHQGRWVASG EQWAVDACTS CSCVAGTVHC QTQRCRKLAC SRDEVPALSP 1200
GSCCLRCLPR PASCMAFGDP HYRTFDGRLL HFQGSCSYVL AKDCHGEDFS 1250
VHVTNDDRGR RGVAWTQEVA VLLGTVAVRL LQGRTVMVDQ HTVTLPFLRE 1300
PLLYIELRGH TVILHAQPGL QVLWDGQSQV EVRVPSSYRG QTCGLCGNFN 1350
GFAQDDLQGP DGRLLPTEAS FGNSWKVPKG LGPGRPCSAG REVDPCRAAG 1400
YRARREANAR CGILKTSPFS HCHAVVPPEP FFAACVYDLC ACGPGSSSDT 1450
CLCDALEAYA SHCRQAGVTP VWRGPTLCVV GCPVDRGFVF DECGPPCPRT 1500
CFNRHIPLGE LAAHCVRPCV PGCQCPAGLV EHEGHCISPE VCPPVLLTGD 1550
Length:1,550
Mass (Da):166,628
Last modified:July 27, 2011 - v2
Checksum:i6E6630EDA239D744
GO
Isoform 2 (identifier: Q3U492-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1255: SVHVTN → RWTSTQ
     1256-1550: Missing.

Note: No experimental confirmation available.

Show »
Length:1,255
Mass (Da):135,115
Checksum:i01A83D89AB0109E6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1250 – 12556SVHVTN → RWTSTQ in isoform 2. VSP_031232
Alternative sequencei1256 – 1550295Missing in isoform 2. VSP_031233Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti385 – 3851F → L in AAX77677. 1 Publication
Sequence conflicti829 – 8291L → F in BAE32541. 1 Publication
Sequence conflicti1045 – 10451Missing in AAX77677. 1 Publication
Sequence conflicti1147 – 11471T → N in BAE32541. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY884211 mRNA. Translation: AAX77677.1.
AK154369 mRNA. Translation: BAE32541.1.
AC079276 Genomic DNA. No translation available.
CCDSiCCDS57415.1. [Q3U492-1]
RefSeqiNP_001025156.3. NM_001029985.4. [Q3U492-1]
UniGeneiMm.332961.

Genome annotation databases

EnsembliENSMUST00000078112; ENSMUSP00000077251; ENSMUSG00000059022. [Q3U492-2]
ENSMUST00000101614; ENSMUSP00000099135; ENSMUSG00000059022. [Q3U492-1]
GeneIDi333088.
KEGGimmu:333088.
UCSCiuc009bdt.2. mouse. [Q3U492-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY884211 mRNA. Translation: AAX77677.1 .
AK154369 mRNA. Translation: BAE32541.1 .
AC079276 Genomic DNA. No translation available.
CCDSi CCDS57415.1. [Q3U492-1 ]
RefSeqi NP_001025156.3. NM_001029985.4. [Q3U492-1 ]
UniGenei Mm.332961.

3D structure databases

ProteinModelPortali Q3U492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000099135.

Proteomic databases

PRIDEi Q3U492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078112 ; ENSMUSP00000077251 ; ENSMUSG00000059022 . [Q3U492-2 ]
ENSMUST00000101614 ; ENSMUSP00000099135 ; ENSMUSG00000059022 . [Q3U492-1 ]
GeneIDi 333088.
KEGGi mmu:333088.
UCSCi uc009bdt.2. mouse. [Q3U492-1 ]

Organism-specific databases

CTDi 375616.
MGIi MGI:2141640. Kcp.

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00730000110288.
HOGENOMi HOG000168484.
InParanoidi Q3U492.
OMAi LVGCPPS.
TreeFami TF106451.

Miscellaneous databases

NextBioi 399938.
PROi Q3U492.
SOURCEi Search...

Gene expression databases

Bgeei Q3U492.
CleanExi MM_CRIM2.
Genevestigatori Q3U492.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00093. VWC. 9 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 17 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 13 hits.
PS50184. VWFC_2. 14 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease."
    Lin J., Patel S.R., Cheng X., Cho E.A., Levitan I., Ullenbruch M., Phan S.H., Park J.M., Dressler G.R.
    Nat. Med. 11:387-393(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH BMP7, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INDUCTION BY RENAL STRESSES.
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia."
    Lin J., Patel S.R., Wang M., Dressler G.R.
    Mol. Cell. Biol. 26:4577-4585(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTIVIN A AND TGFB1.

Entry informationi

Entry nameiKCP_MOUSE
AccessioniPrimary (citable) accession number: Q3U492
Secondary accession number(s): E9QJU0, Q56NI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi