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Q3U492

- KCP_MOUSE

UniProt

Q3U492 - KCP_MOUSE

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Protein

Kielin/chordin-like protein

Gene

Kcp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.1 Publication

GO - Biological processi

  1. hematopoietic progenitor cell differentiation Source: MGI
  2. positive regulation of BMP signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kielin/chordin-like protein
Alternative name(s):
Cysteine-rich BMP regulator 2
Cysteine-rich motor neuron 2 protein
Short name:
CRIM-2
Kielin/chordin-like protein 1
Short name:
KCP-1
Gene namesi
Name:Kcp
Synonyms:Crim2, Kcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2141640. Kcp.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 15501529Kielin/chordin-like proteinPRO_0000318587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1236 ↔ 1244PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ3U492.

Expressioni

Tissue specificityi

Weakly expressed in embryonic kidney and brain. Not expressed in adult tissues and several cell lines.1 Publication

Developmental stagei

Prominently expressed in two areas, the limb buds and the developing kidney, with diffuse staining in the central nervous system. At E9.5 the limb bud mesenchyme is positive. Expression in the kidney region could be detected as early as E9 in the intermediate mesoderm. By E10, the mesonephric tubules and nephric ducts are clearly positive. At later stages, high levels are localized to the developing tubules. At E18.5, it is localized to more mature renal tubules located in the developing cortex with little expression detected in the nephrogenic zone.1 Publication

Inductioni

By renal stresses.1 Publication

Gene expression databases

BgeeiQ3U492.
CleanExiMM_CRIM2.
ExpressionAtlasiQ3U492. baseline and differential.
GenevestigatoriQ3U492.

Interactioni

Subunit structurei

Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099135.

Structurei

3D structure databases

ProteinModelPortaliQ3U492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 19158VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 25160VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 31260VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini313 – 37058VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini371 – 42555VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini426 – 48560VWFC 6PROSITE-ProRule annotationAdd
BLAST
Domaini486 – 54459VWFC 7PROSITE-ProRule annotationAdd
BLAST
Domaini545 – 60258VWFC 8PROSITE-ProRule annotationAdd
BLAST
Domaini603 – 66159VWFC 9PROSITE-ProRule annotationAdd
BLAST
Domaini665 – 72460VWFC 10PROSITE-ProRule annotationAdd
BLAST
Domaini725 – 78157VWFC 11PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 84059VWFC 12PROSITE-ProRule annotationAdd
BLAST
Domaini841 – 90262VWFC 13PROSITE-ProRule annotationAdd
BLAST
Domaini903 – 95856VWFC 14PROSITE-ProRule annotationAdd
BLAST
Domaini959 – 101658VWFC 15PROSITE-ProRule annotationAdd
BLAST
Domaini1017 – 108468VWFC 16PROSITE-ProRule annotationAdd
BLAST
Domaini1085 – 114460VWFC 17PROSITE-ProRule annotationAdd
BLAST
Domaini1148 – 120861VWFC 18PROSITE-ProRule annotationAdd
BLAST
Domaini1213 – 1425213VWFDPROSITE-ProRule annotationAdd
BLAST
Domaini1489 – 154254TILAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 9233Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 18 VWFC domains.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000168484.
InParanoidiQ3U492.
OMAiLVGCPPS.
TreeFamiTF106451.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00093. VWC. 9 hits.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00832. C8. 1 hit.
SM00214. VWC. 17 hits.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 1 hit.
PROSITEiPS01208. VWFC_1. 13 hits.
PS50184. VWFC_2. 14 hits.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3U492-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGARAALLP LLLHLGSLAL AARGGEVSRE QPRLADAISQ QQAPSHSLVP
60 70 80 90 100
GETHQQQWCP LEERLERLEA EVTDLRKQNR ELQARVVQLE SCECWGPGHT
110 120 130 140 150
CPEGARWEPD ACTACVCRDG TAHCGPQPNL PHCRGCSHNG QSYGHGETFS
160 170 180 190 200
PDACTTCRCL AGTVQCQGPS CSELNCLESF IPPGECCPIC RPGCEYEGQL
210 220 230 240 250
HQEGSSFLSS SNPCLQCSCL RSLVRCVPVK CQPSPCLNPV PRLGHCCPVC
260 270 280 290 300
QASGCTEGNS HRDHGQEWTT PGDPCRICQC LEGHIQCRQR ECASLCPYPA
310 320 330 340 350
RPLPGTCCPV CDGCFLNGRE HSSGEPVGSQ DPCSSCRCTN GSVQCEPLPC
360 370 380 390 400
PPAPCRYPGR IPGQCCPVCD GCKYQGHEYR SQETFTLQEN GRCLRCVCQA
410 420 430 440 450
GEVSCEEQDC PVTPCVRSAS GPQLCSACVL NGEEFAEGIQ WEPDDQPCTS
460 470 480 490 500
CSCQDGVPVC RAVLCSPVPC QHPTQPPGAC CPSCDSCTYH SLVYANGQNF
510 520 530 540 550
TDVDSPCQTC YCEDGTVRCS LINCPFTTCA KPQNGPGQCC PKCPDCILEA
560 570 580 590 600
QVFVDGERFP HPRDPCQECW CQEGQAHCQL RACPSAPCVH PLPGTCCKND
610 620 630 640 650
CTGCAFGGKE YPNGADFPHP TDPCRLCRCL SGNVQCLARR CPPLSCPQPV
660 670 680 690 700
LTPGDCCPQC PDAPADCPQS GNMVPVRHQE HFFQPGDPCS RCLCLDGSVS
710 720 730 740 750
CQRLTCPPAP CAHPRRDACC PSCDGCLYQG KEFASGERFP SPNVACHVCL
760 770 780 790 800
CWEGSVKCEP RTCAPAQCPF PTREDCCPAC DSCDYLGVSY LSSQEFPDPR
810 820 830 840 850
EACNLCTCLG GFVTCTRRPC EPPACSHPLI VPEHCCPTCQ GCLYHGITAA
860 870 880 890 900
LGETLPDPLD PTCSLCTCEE GSMRCQKKPC PPAPCAHPSP GPCFCPVCRS
910 920 930 940 950
CLSQGREHQD GEEFEGPEGS CERCRCLAGQ VSCTRLQCPS LPCLHQVTEP
960 970 980 990 1000
GTCCPRCTGC LARGEEHPEG SSWVPADSPC SSCMCHKGII TCAQVQCVSA
1010 1020 1030 1040 1050
CIWPQEGPSD CCPQCSGCEH GGRKYEPGES FQPGADPCEV CICKQKREGP
1060 1070 1080 1090 1100
PSLHCSRRQC PSLVGCPPSQ LLPPGPQHCC PTCAQALSNC TEDLVGSELV
1110 1120 1130 1140 1150
PPDPCYTCQC QDLTWLCTHR ACPELSCPLW ERHTTPGSCC PVCKDPTQSC
1160 1170 1180 1190 1200
MHQGRWVASG EQWAVDACTS CSCVAGTVHC QTQRCRKLAC SRDEVPALSP
1210 1220 1230 1240 1250
GSCCLRCLPR PASCMAFGDP HYRTFDGRLL HFQGSCSYVL AKDCHGEDFS
1260 1270 1280 1290 1300
VHVTNDDRGR RGVAWTQEVA VLLGTVAVRL LQGRTVMVDQ HTVTLPFLRE
1310 1320 1330 1340 1350
PLLYIELRGH TVILHAQPGL QVLWDGQSQV EVRVPSSYRG QTCGLCGNFN
1360 1370 1380 1390 1400
GFAQDDLQGP DGRLLPTEAS FGNSWKVPKG LGPGRPCSAG REVDPCRAAG
1410 1420 1430 1440 1450
YRARREANAR CGILKTSPFS HCHAVVPPEP FFAACVYDLC ACGPGSSSDT
1460 1470 1480 1490 1500
CLCDALEAYA SHCRQAGVTP VWRGPTLCVV GCPVDRGFVF DECGPPCPRT
1510 1520 1530 1540 1550
CFNRHIPLGE LAAHCVRPCV PGCQCPAGLV EHEGHCISPE VCPPVLLTGD
Length:1,550
Mass (Da):166,628
Last modified:July 27, 2011 - v2
Checksum:i6E6630EDA239D744
GO
Isoform 2 (identifier: Q3U492-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1255: SVHVTN → RWTSTQ
     1256-1550: Missing.

Note: No experimental confirmation available.

Show »
Length:1,255
Mass (Da):135,115
Checksum:i01A83D89AB0109E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti385 – 3851F → L in AAX77677. (PubMed:15793581)Curated
Sequence conflicti829 – 8291L → F in BAE32541. (PubMed:16141072)Curated
Sequence conflicti1045 – 10451Missing in AAX77677. (PubMed:15793581)Curated
Sequence conflicti1147 – 11471T → N in BAE32541. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1250 – 12556SVHVTN → RWTSTQ in isoform 2. 1 PublicationVSP_031232
Alternative sequencei1256 – 1550295Missing in isoform 2. 1 PublicationVSP_031233Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY884211 mRNA. Translation: AAX77677.1.
AK154369 mRNA. Translation: BAE32541.1.
AC079276 Genomic DNA. No translation available.
CCDSiCCDS57415.1. [Q3U492-1]
RefSeqiNP_001025156.3. NM_001029985.4. [Q3U492-1]
UniGeneiMm.332961.

Genome annotation databases

EnsembliENSMUST00000078112; ENSMUSP00000077251; ENSMUSG00000059022. [Q3U492-2]
ENSMUST00000101614; ENSMUSP00000099135; ENSMUSG00000059022. [Q3U492-1]
GeneIDi333088.
KEGGimmu:333088.
UCSCiuc009bdt.2. mouse. [Q3U492-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY884211 mRNA. Translation: AAX77677.1 .
AK154369 mRNA. Translation: BAE32541.1 .
AC079276 Genomic DNA. No translation available.
CCDSi CCDS57415.1. [Q3U492-1 ]
RefSeqi NP_001025156.3. NM_001029985.4. [Q3U492-1 ]
UniGenei Mm.332961.

3D structure databases

ProteinModelPortali Q3U492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000099135.

Proteomic databases

PRIDEi Q3U492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078112 ; ENSMUSP00000077251 ; ENSMUSG00000059022 . [Q3U492-2 ]
ENSMUST00000101614 ; ENSMUSP00000099135 ; ENSMUSG00000059022 . [Q3U492-1 ]
GeneIDi 333088.
KEGGi mmu:333088.
UCSCi uc009bdt.2. mouse. [Q3U492-1 ]

Organism-specific databases

CTDi 375616.
MGIi MGI:2141640. Kcp.

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00760000118896.
HOGENOMi HOG000168484.
InParanoidi Q3U492.
OMAi LVGCPPS.
TreeFami TF106451.

Miscellaneous databases

NextBioi 399938.
PROi Q3U492.
SOURCEi Search...

Gene expression databases

Bgeei Q3U492.
CleanExi MM_CRIM2.
ExpressionAtlasi Q3U492. baseline and differential.
Genevestigatori Q3U492.

Family and domain databases

InterProi IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00093. VWC. 9 hits.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00832. C8. 1 hit.
SM00214. VWC. 17 hits.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 1 hit.
PROSITEi PS01208. VWFC_1. 13 hits.
PS50184. VWFC_2. 14 hits.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease."
    Lin J., Patel S.R., Cheng X., Cho E.A., Levitan I., Ullenbruch M., Phan S.H., Park J.M., Dressler G.R.
    Nat. Med. 11:387-393(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH BMP7, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INDUCTION BY RENAL STRESSES.
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia."
    Lin J., Patel S.R., Wang M., Dressler G.R.
    Mol. Cell. Biol. 26:4577-4585(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTIVIN A AND TGFB1.

Entry informationi

Entry nameiKCP_MOUSE
AccessioniPrimary (citable) accession number: Q3U492
Secondary accession number(s): E9QJU0, Q56NI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3