SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3U485

- Q3U485_MOUSE

UniProt

Q3U485 - Q3U485_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Putative uncharacterized protein
Gene
Tgfbr1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta binding Source: MGI
  5. transforming growth factor beta receptor activity, type I Source: Ensembl
  6. transforming growth factor beta-activated receptor activity Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. angiogenesis Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. artery morphogenesis Source: MGI
  5. blastocyst development Source: MGI
  6. collagen fibril organization Source: MGI
  7. embryonic cranial skeleton morphogenesis Source: MGI
  8. endothelial cell migration Source: MGI
  9. epithelial to mesenchymal transition Source: Ensembl
  10. germ cell migration Source: MGI
  11. heart development Source: MGI
  12. in utero embryonic development Source: MGI
  13. kidney development Source: MGI
  14. lens development in camera-type eye Source: MGI
  15. negative regulation of apoptotic process Source: MGI
  16. negative regulation of endothelial cell proliferation Source: MGI
  17. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  18. neuron fate commitment Source: MGI
  19. palate development Source: MGI
  20. parathyroid gland development Source: MGI
  21. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  22. peptidyl-serine phosphorylation Source: Ensembl
  23. peptidyl-threonine phosphorylation Source: Ensembl
  24. pharyngeal system development Source: MGI
  25. positive regulation of SMAD protein import into nucleus Source: Ensembl
  26. positive regulation of apoptotic signaling pathway Source: Ensembl
  27. positive regulation of cell growth Source: Ensembl
  28. positive regulation of cell proliferation Source: Ensembl
  29. positive regulation of cellular component movement Source: Ensembl
  30. positive regulation of filopodium assembly Source: MGI
  31. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  32. positive regulation of protein kinase B signaling Source: Ensembl
  33. positive regulation of transcription, DNA-templated Source: Ensembl
  34. post-embryonic development Source: MGI
  35. regulation of gene expression Source: MGI
  36. regulation of protein binding Source: MGI
  37. regulation of protein ubiquitination Source: Ensembl
  38. skeletal system development Source: MGI
  39. skeletal system morphogenesis Source: MGI
  40. thymus development Source: MGI
  41. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotations, Serine/threonine-protein kinaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
  4. receptor complex Source: Ensembl
  5. tight junction Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ3U485.
BgeeiQ3U485.
GenevestigatoriQ3U485.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG054502.
InParanoidiQ3U485.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3U485-1 [UniParc]FASTAAdd to Basket

« Hide

RPFVCAPSSK TGAVTTTYCC NQDHCNKIEL PTTGPFSEKQ SAGLGPVELA    50
AVIAGPVCFV CIALMLMVYI CHNRTVIHHR VPNEEDPSLD RPFISEGTTL 100
KDLIYDMTTS GSGSGLPLLV QRTIARTIVL QESIGKGRFG EVWRGKWRGE 150
EVAVKIFSSR EERSWFREAE IYQTVMLRHE NILGFIAADN KDNGTWTQLW 200
LVSDYHEHGS LFDYLNRYTV TVEGMIKLAL STASGLAHLH MEIVGTQGKP 250
AIAHRDLKSK NILVKKNGTC CIADLGLAVR HDSATDTIDI APNHRVGTKR 300
YMAPEVLDDS INMKHFESFK RADIYAMGLV FWEIARRCSI GGIHEDYQLP 350
YYDLVPSDPS VEEMRKVVCE QKLRPNIPNR WQSCEALRVM AKIMRECWYA 400
NGAARLTALR IKKTLSQLSQ QEGIKM 426
Length:426
Mass (Da):47,906
Last modified:October 11, 2005 - v1
Checksum:i72E75751DD1015B7
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK154381 mRNA. Translation: BAE32548.1.
UniGeneiMm.197552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK154381 mRNA. Translation: BAE32548.1 .
UniGenei Mm.197552.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98728. Tgfbr1.

Phylogenomic databases

HOVERGENi HBG054502.
InParanoidi Q3U485.

Miscellaneous databases

ChiTaRSi TGFBR1. mouse.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3U485.
Bgeei Q3U485.
Genevestigatori Q3U485.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U485_MOUSE
AccessioniPrimary (citable) accession number: Q3U485
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi