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Protein

Receptor protein serine/threonine kinase

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. I-SMAD binding Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. receptor signaling protein serine/threonine kinase activity Source: InterPro
  6. SMAD binding Source: MGI
  7. transforming growth factor beta-activated receptor activity Source: MGI
  8. transforming growth factor beta binding Source: MGI
  9. transforming growth factor beta receptor activity, type I Source: MGI
  10. type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. angiogenesis Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. artery morphogenesis Source: MGI
  5. blastocyst development Source: MGI
  6. cell motility Source: MGI
  7. cellular response to transforming growth factor beta stimulus Source: MGI
  8. collagen fibril organization Source: MGI
  9. embryonic cranial skeleton morphogenesis Source: MGI
  10. endothelial cell migration Source: MGI
  11. epithelial to mesenchymal transition Source: MGI
  12. germ cell migration Source: MGI
  13. heart development Source: MGI
  14. in utero embryonic development Source: MGI
  15. kidney development Source: MGI
  16. lens development in camera-type eye Source: MGI
  17. male gonad development Source: MGI
  18. negative regulation of apoptotic process Source: MGI
  19. negative regulation of endothelial cell proliferation Source: MGI
  20. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  21. neuron fate commitment Source: MGI
  22. palate development Source: MGI
  23. parathyroid gland development Source: MGI
  24. pathway-restricted SMAD protein phosphorylation Source: MGI
  25. peptidyl-serine phosphorylation Source: MGI
  26. peptidyl-threonine phosphorylation Source: MGI
  27. pharyngeal system development Source: MGI
  28. positive regulation of apoptotic signaling pathway Source: MGI
  29. positive regulation of cell growth Source: MGI
  30. positive regulation of cell proliferation Source: MGI
  31. positive regulation of cellular component movement Source: MGI
  32. positive regulation of filopodium assembly Source: MGI
  33. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  34. positive regulation of protein kinase B signaling Source: MGI
  35. positive regulation of SMAD protein import into nucleus Source: MGI
  36. positive regulation of transcription, DNA-templated Source: MGI
  37. post-embryonic development Source: MGI
  38. protein phosphorylation Source: MGI
  39. regulation of gene expression Source: MGI
  40. regulation of protein binding Source: MGI
  41. regulation of protein ubiquitination Source: MGI
  42. regulation of transcription, DNA-templated Source: MGI
  43. response to cholesterol Source: MGI
  44. signal transduction Source: MGI
  45. skeletal system development Source: MGI
  46. skeletal system morphogenesis Source: MGI
  47. thymus development Source: MGI
  48. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
  4. plasma membrane Source: MGI
  5. receptor complex Source: MGI
  6. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ3U485.
ExpressionAtlasiQ3U485. baseline and differential.
GenevestigatoriQ3U485.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG054502.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3U485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RPFVCAPSSK TGAVTTTYCC NQDHCNKIEL PTTGPFSEKQ SAGLGPVELA
60 70 80 90 100
AVIAGPVCFV CIALMLMVYI CHNRTVIHHR VPNEEDPSLD RPFISEGTTL
110 120 130 140 150
KDLIYDMTTS GSGSGLPLLV QRTIARTIVL QESIGKGRFG EVWRGKWRGE
160 170 180 190 200
EVAVKIFSSR EERSWFREAE IYQTVMLRHE NILGFIAADN KDNGTWTQLW
210 220 230 240 250
LVSDYHEHGS LFDYLNRYTV TVEGMIKLAL STASGLAHLH MEIVGTQGKP
260 270 280 290 300
AIAHRDLKSK NILVKKNGTC CIADLGLAVR HDSATDTIDI APNHRVGTKR
310 320 330 340 350
YMAPEVLDDS INMKHFESFK RADIYAMGLV FWEIARRCSI GGIHEDYQLP
360 370 380 390 400
YYDLVPSDPS VEEMRKVVCE QKLRPNIPNR WQSCEALRVM AKIMRECWYA
410 420
NGAARLTALR IKKTLSQLSQ QEGIKM
Length:426
Mass (Da):47,906
Last modified:October 11, 2005 - v1
Checksum:i72E75751DD1015B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154381 mRNA. Translation: BAE32548.1.
UniGeneiMm.197552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154381 mRNA. Translation: BAE32548.1.
UniGeneiMm.197552.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3U485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Phylogenomic databases

HOVERGENiHBG054502.

Miscellaneous databases

ChiTaRSiTgfbr1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U485.
ExpressionAtlasiQ3U485. baseline and differential.
GenevestigatoriQ3U485.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U485_MOUSE
AccessioniPrimary (citable) accession number: Q3U485
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.