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Protein
Submitted name:

Tumor necrosis factor receptor superfamily, member 1a

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily, member 1aImported
Gene namesi
Name:Tnfrsf1aImported
ORF Names:mCG_129428Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1314884 Tnfrsf1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 235HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501430920630 – 454Sequence analysisAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiQ3U479

Expressioni

Gene expression databases

BgeeiENSMUSG00000030341
ExpressionAtlasiQ3U479 baseline and differential

Structurei

3D structure databases

SMRiQ3U479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 81TNFR-CysInterPro annotationAdd BLAST39
Repeati43 – 81TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Repeati83 – 125TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini126 – 166TNFR-CysInterPro annotationAdd BLAST41
Repeati126 – 166TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini356 – 441DeathInterPro annotationAdd BLAST86

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
HOVERGENiHBG058842
KOiK03158
OMAiGCLEDIE
OrthoDBiEOG091G07LE

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd10576 TNFRSF1A, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020419 TNFR_1A
IPR033994 TNFRSF1A_death
IPR033993 TNFRSF1A_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 3 hits
PRINTSiPR01918 TNFACTORR1A
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q3U479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV
60 70 80 90 100
HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL
110 120 130 140 150
SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL
210 220 230 240 250
ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW RPEVYSIICR
260 270 280 290 300
DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP
310 320 330 340 350
IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR
360 370 380 390 400
PDNADLAILY AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ
410 420 430 440 450
YSMLEAWRRR TPRHEDTLEV VGLVLSKMNL AGCLENILEA LRNPAPSSTT

RLPR
Length:454
Mass (Da):50,130
Last modified:October 11, 2005 - v1
Checksum:i0710C2E8C3C2B6D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154388 mRNA Translation: BAE32554.1
CH466523 Genomic DNA Translation: EDK99828.1
RefSeqiNP_035739.2, NM_011609.4
UniGeneiMm.1258
Mm.474976

Genome annotation databases

GeneIDi21937
KEGGimmu:21937

Similar proteinsi

Entry informationi

Entry nameiQ3U479_MOUSE
AccessioniPrimary (citable) accession number: Q3U479
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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