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Protein
Submitted name:

Putative uncharacterized protein

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Submitted name:
Tumor necrosis factor receptor superfamily, member 1aImported
Gene namesi
Name:Tnfrsf1aImported
ORF Names:mCG_129428Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 235HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500934287730 – 454Sequence analysisAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000030341.
ExpressionAtlasiQ3U479. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Structurei

3D structure databases

SMRiQ3U479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 81TNFR-CysInterPro annotationAdd BLAST39
Repeati43 – 81TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Repeati83 – 125TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini126 – 166TNFR-CysInterPro annotationAdd BLAST41
Repeati126 – 166TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini356 – 441DeathInterPro annotationAdd BLAST86

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOVERGENiHBG058842.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.

Family and domain databases

CDDicd08313. Death_TNFR1. 1 hit.
cd10576. TNFRSF1A. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033994. TNFRSF1A_death.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q3U479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV
60 70 80 90 100
HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL
110 120 130 140 150
SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL
210 220 230 240 250
ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW RPEVYSIICR
260 270 280 290 300
DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP
310 320 330 340 350
IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR
360 370 380 390 400
PDNADLAILY AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ
410 420 430 440 450
YSMLEAWRRR TPRHEDTLEV VGLVLSKMNL AGCLENILEA LRNPAPSSTT

RLPR
Length:454
Mass (Da):50,130
Last modified:October 11, 2005 - v1
Checksum:i0710C2E8C3C2B6D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154388 mRNA. Translation: BAE32554.1.
CH466523 Genomic DNA. Translation: EDK99828.1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

Genome annotation databases

GeneIDi21937.
KEGGimmu:21937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154388 mRNA. Translation: BAE32554.1.
CH466523 Genomic DNA. Translation: EDK99828.1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

3D structure databases

SMRiQ3U479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21937.
KEGGimmu:21937.

Organism-specific databases

CTDi7132.
MGIiMGI:1314884. Tnfrsf1a.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOVERGENiHBG058842.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030341.
ExpressionAtlasiQ3U479. baseline and differential.

Family and domain databases

CDDicd08313. Death_TNFR1. 1 hit.
cd10576. TNFRSF1A. 1 hit.
Gene3Di1.10.533.10. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033994. TNFRSF1A_death.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U479_MOUSE
AccessioniPrimary (citable) accession number: Q3U479
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 15, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.