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Protein
Submitted name:

Tumor necrosis factor receptor superfamily, member 1a

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily, member 1aImported
Gene namesi
Name:Tnfrsf1aImported
ORF Names:mCG_129428Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei213 – 23523HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 454425Sequence analysisPRO_5007923576Add
BLAST

Expressioni

Gene expression databases

BgeeiENSMUSG00000030341.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 8139TNFR-CysInterPro annotationAdd
BLAST
Domaini83 – 12543TNFR-CysInterPro annotationAdd
BLAST
Domaini126 – 16641TNFR-CysInterPro annotationAdd
BLAST
Domaini356 – 44186DeathInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.
HOVERGENiHBG058842.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV
60 70 80 90 100
HSKNNSICCT KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL
110 120 130 140 150
SCKTCRKEMS QVEISPCQAD KDTVCGCKEN QFQRYLSETH FQCVDCSPCF
160 170 180 190 200
NGTVTIPCKE TQNTVCNCHA GFFLRESECV PCSHCKKNEE CMKLCLPPPL
210 220 230 240 250
ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW RPEVYSIICR
260 270 280 290 300
DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP
310 320 330 340 350
IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR
360 370 380 390 400
PDNADLAILY AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ
410 420 430 440 450
YSMLEAWRRR TPRHEDTLEV VGLVLSKMNL AGCLENILEA LRNPAPSSTT

RLPR
Length:454
Mass (Da):50,130
Last modified:October 11, 2005 - v1
Checksum:i0710C2E8C3C2B6D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154388 mRNA. Translation: BAE32554.1.
CH466523 Genomic DNA. Translation: EDK99828.1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

Genome annotation databases

GeneIDi21937.
KEGGimmu:21937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154388 mRNA. Translation: BAE32554.1.
CH466523 Genomic DNA. Translation: EDK99828.1.
RefSeqiNP_035739.2. NM_011609.4.
UniGeneiMm.1258.
Mm.474976.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21937.
KEGGimmu:21937.

Organism-specific databases

CTDi7132.
MGIiMGI:1314884. Tnfrsf1a.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.
HOVERGENiHBG058842.
KOiK03158.
OMAiCLREAHY.
OrthoDBiEOG091G07LE.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030341.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U479_MOUSE
AccessioniPrimary (citable) accession number: Q3U479
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.