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Q3U435

- MMP25_MOUSE

UniProt

Q3U435 - MMP25_MOUSE

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Protein
Matrix metalloproteinase-25
Gene
Mmp25
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May activate progelatinase A By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.
Calcium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi145 – 1451Zinc; in inhibited form By similarity
Metal bindingi287 – 2871Zinc; catalytic By similarity
Active sitei288 – 2881 By similarity
Metal bindingi291 – 2911Zinc; catalytic By similarity
Metal bindingi297 – 2971Zinc; catalytic By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. hard palate development Source: MGI
  2. inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM10.024.

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinase-25 (EC:3.4.24.-)
Short name:
MMP-25
Gene namesi
Name:Mmp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2443938. Mmp25.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular matrix Source: InterPro
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 162162 By similarity
PRO_0000288635Add
BLAST
Chaini163 – 593431Matrix metalloproteinase-25
PRO_0000288636Add
BLAST
Propeptidei594 – 61522Removed in mature form Reviewed prediction
PRO_0000288637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi371 ↔ 562 By similarity
Lipidationi593 – 5931GPI-anchor amidated alanine Reviewed prediction

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Zymogen

Proteomic databases

PRIDEiQ3U435.

PTM databases

PhosphoSiteiQ3U435.

Expressioni

Gene expression databases

BgeeiQ3U435.
CleanExiMM_MMP25.
GenevestigatoriQ3U435.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024696.

Structurei

3D structure databases

ProteinModelPortaliQ3U435.
SMRiQ3U435. Positions 113-564.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati368 – 41750Hemopexin 1
Add
BLAST
Repeati421 – 46646Hemopexin 2
Add
BLAST
Repeati467 – 51549Hemopexin 3
Add
BLAST
Repeati516 – 56247Hemopexin 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi143 – 1508Cysteine switch By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1625Poly-Arg
Compositional biasi340 – 36829Pro-rich
Add
BLAST

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295915.
GeneTreeiENSGT00750000117336.
HOGENOMiHOG000217928.
HOVERGENiHBG052484.
InParanoidiQ3U435.
KOiK08003.
OMAiHYWRFPK.
OrthoDBiEOG7XPZ57.
PhylomeDBiQ3U435.
TreeFamiTF315428.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028733. MMP25.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF21. PTHR10201:SF21. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U435-1 [UniParc]FASTAAdd to Basket

« Hide

MCFPGSQISP ARLYYLVSAP WICTGSLTSS RLPRRRESGP LRVPPRSVQA    50
ERILRLPAFG LPLLALLLVP LLPVRAQNPD AKVVSMGVEW LTRYGYLPPA 100
DPVHAQMQSL EKLQDAIKVM QRFAGLPETG QMDPMTIKTM RKPRCSLPDV 150
LGAAGLVRRR RRYSLSGSVW KKRTLTWSIR SFSQKSQLSP QIVRTLLSYA 200
LAVWATESGL TFQEVNSQYQ EPDIIIHFAR AYHQDSYPFD GSGGTLAHAF 250
FPGEHPISGD THFDDEETWT FGSTDDNGID LFAVAVHEFG HALGLGHSSA 300
PNSIMRPFYQ GPVGDPATYR LPQDDRDGLQ QLYGRVSQNP NARPTRKPLV 350
PPPQPPAMPP DSPATPVPDR CEGNFDAVAN IRGEIFLFKG PWFWRLQPSG 400
QLVSPRPAGL HRFWEGLPTH VKVIQAAYAR PLDGRIILFS GPQFWVFQER 450
QLEGAARPLV EFGLPPGEDV DAVFSWPHNG KTYLIRGQKY WRYDEVAARP 500
DPGYPRALSL WDGAPFAPDD VTISNTGDTY FFKGTHFWRF AEGSVKAESD 550
SPQPIGPKWL DCPAPNSDPR VTSPPKTTSK TRSCDCHCEL NQASEQLSPL 600
LLPLLPLVAG EVFSY 615
Length:615
Mass (Da):68,496
Last modified:October 11, 2005 - v1
Checksum:i7B0842CACF06382D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK154458 mRNA. Translation: BAE32600.1.
BC112379 mRNA. Translation: AAI12380.1.
CCDSiCCDS28452.1.
RefSeqiNP_001028511.1. NM_001033339.3.
UniGeneiMm.235343.

Genome annotation databases

EnsembliENSMUST00000024696; ENSMUSP00000024696; ENSMUSG00000023903.
GeneIDi240047.
KEGGimmu:240047.
UCSCiuc008asq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK154458 mRNA. Translation: BAE32600.1 .
BC112379 mRNA. Translation: AAI12380.1 .
CCDSi CCDS28452.1.
RefSeqi NP_001028511.1. NM_001033339.3.
UniGenei Mm.235343.

3D structure databases

ProteinModelPortali Q3U435.
SMRi Q3U435. Positions 113-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000024696.

Protein family/group databases

MEROPSi M10.024.

PTM databases

PhosphoSitei Q3U435.

Proteomic databases

PRIDEi Q3U435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024696 ; ENSMUSP00000024696 ; ENSMUSG00000023903 .
GeneIDi 240047.
KEGGi mmu:240047.
UCSCi uc008asq.1. mouse.

Organism-specific databases

CTDi 64386.
MGIi MGI:2443938. Mmp25.

Phylogenomic databases

eggNOGi NOG295915.
GeneTreei ENSGT00750000117336.
HOGENOMi HOG000217928.
HOVERGENi HBG052484.
InParanoidi Q3U435.
KOi K08003.
OMAi HYWRFPK.
OrthoDBi EOG7XPZ57.
PhylomeDBi Q3U435.
TreeFami TF315428.

Miscellaneous databases

NextBioi 384387.
PROi Q3U435.
SOURCEi Search...

Gene expression databases

Bgeei Q3U435.
CleanExi MM_MMP25.
Genevestigatori Q3U435.

Family and domain databases

Gene3Di 1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028733. MMP25.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
PANTHERi PTHR10201:SF21. PTHR10201:SF21. 1 hit.
Pfami PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMMP25_MOUSE
AccessioniPrimary (citable) accession number: Q3U435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to the human ortholog it does not have a signal sequence as it has an additional 53 residue sequence at the N-terminus. At the position of the human initiation methionine there is a leucine (Leu-54).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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