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Protein

Kelch-like protein 21

Gene

Klhl21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 21
Gene namesi
Name:Klhl21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919288. Klhl21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261281 – 597Kelch-like protein 21Add BLAST597

Proteomic databases

PaxDbiQ3U410.
PRIDEiQ3U410.

PTM databases

PhosphoSitePlusiQ3U410.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073700.
CleanExiMM_KLHL21.
GenevisibleiQ3U410. MM.

Interactioni

Subunit structurei

Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.By similarity

Protein-protein interaction databases

BioGridi232459. 15 interactors.
IntActiQ3U410. 16 interactors.
STRINGi10090.ENSMUSP00000095380.

Structurei

3D structure databases

ProteinModelPortaliQ3U410.
SMRiQ3U410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 103BTBPROSITE-ProRule annotationAdd BLAST69
Domaini138 – 239BACKAdd BLAST102
Repeati287 – 335Kelch 1Add BLAST49
Repeati336 – 382Kelch 2Add BLAST47
Repeati384 – 422Kelch 3Add BLAST39
Repeati423 – 470Kelch 4Add BLAST48
Repeati472 – 512Kelch 5Add BLAST41
Repeati513 – 560Kelch 6Add BLAST48

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ3U410.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiQ3U410.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPAPLAVL PFSDPAHALS LLRGLSQLRA ERKFLDVTLE AAGGRDFPAH
60 70 80 90 100
RAVLAAASPY FRAMFAGQLR ESRAERVRLH GVPPDMLQLL LDFSYTGRVA
110 120 130 140 150
VSGDNAEPLL RAADLLQFPA VKEACGAFLQ QQLDLANCLD MQDFAEAFSC
160 170 180 190 200
SGLASAAQRF ILRHVGELGA EQLERLPLAR LLRYLRDDGL CVPKEEAAYQ
210 220 230 240 250
LALRWVRADP PRRAPHWPQL LEAVRLPFVR RFYLLAHVEA EPLVARCPPC
260 270 280 290 300
LRLLREARDF QAARYDRHDR GPCPRMRPRP STGLAEILVL VGGCDQDCDE
310 320 330 340 350
LVTVDCYNPQ TGQWRYLAEF PDHLGGGYSI VALGNDIYVT GGSDGSRLYD
360 370 380 390 400
CVWRYNSSVN EWTEVAPMLK AREYHSSSVL DGLLYVVAAD STERYDHATD
410 420 430 440 450
SWEALQPMTY PMDNCSTTAC RGRLYAIGSL AGKETMVIQC YDPDTDLWSL
460 470 480 490 500
VNCGQLPPWS FAPKTVTLNG LMYFVRDDSA EVDVYNPTKD EWDKIPSMNQ
510 520 530 540 550
VHVGGSLAVL GGKLYVSGGY DNTFELSDVV EAYDPETRAW SVVGRLPEPT
560 570 580 590
FWHGSVSIFR QFMPQTPAGG RGFELNSGSN DVDAGYHRLP QNPEELH
Length:597
Mass (Da):66,547
Last modified:October 11, 2005 - v1
Checksum:i1EE233F7F8D6F5DD
GO

Sequence cautioni

The sequence BAE34380 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti382G → S in BAE34380 (PubMed:16141072).Curated1
Sequence conflicti438I → V in BAE34380 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154493 mRNA. Translation: BAE32625.1.
AK158141 mRNA. Translation: BAE34380.1. Different initiation.
AL611927 Genomic DNA. Translation: CAM24575.1.
CH466594 Genomic DNA. Translation: EDL14916.1.
BC141158 mRNA. Translation: AAI41159.1.
BC141159 mRNA. Translation: AAI41160.1.
CCDSiCCDS18983.1.
RefSeqiNP_001028524.1. NM_001033352.3.
UniGeneiMm.22306.

Genome annotation databases

EnsembliENSMUST00000097773; ENSMUSP00000095380; ENSMUSG00000073700.
GeneIDi242785.
KEGGimmu:242785.
UCSCiuc008vyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154493 mRNA. Translation: BAE32625.1.
AK158141 mRNA. Translation: BAE34380.1. Different initiation.
AL611927 Genomic DNA. Translation: CAM24575.1.
CH466594 Genomic DNA. Translation: EDL14916.1.
BC141158 mRNA. Translation: AAI41159.1.
BC141159 mRNA. Translation: AAI41160.1.
CCDSiCCDS18983.1.
RefSeqiNP_001028524.1. NM_001033352.3.
UniGeneiMm.22306.

3D structure databases

ProteinModelPortaliQ3U410.
SMRiQ3U410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232459. 15 interactors.
IntActiQ3U410. 16 interactors.
STRINGi10090.ENSMUSP00000095380.

PTM databases

PhosphoSitePlusiQ3U410.

Proteomic databases

PaxDbiQ3U410.
PRIDEiQ3U410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097773; ENSMUSP00000095380; ENSMUSG00000073700.
GeneIDi242785.
KEGGimmu:242785.
UCSCiuc008vyy.1. mouse.

Organism-specific databases

CTDi9903.
MGIiMGI:1919288. Klhl21.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000261671.
HOVERGENiHBG101644.
InParanoidiQ3U410.
KOiK10458.
OMAiWVRADPP.
OrthoDBiEOG091G0380.
PhylomeDBiQ3U410.
TreeFamiTF329218.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiKlhl21. mouse.
PROiQ3U410.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073700.
CleanExiMM_KLHL21.
GenevisibleiQ3U410. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH21_MOUSE
AccessioniPrimary (citable) accession number: Q3U410
Secondary accession number(s): B1AS70, Q3TZ30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.