Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mesoderm induction early response protein 2

Gene

Mier2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm induction early response protein 2
Short name:
Mi-er2
Gene namesi
Name:Mier2
Synonyms:Kiaa1193
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917677. Mier2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Mesoderm induction early response protein 2PRO_0000313679Add
BLAST

Proteomic databases

EPDiQ3U3N0.
MaxQBiQ3U3N0.
PaxDbiQ3U3N0.
PRIDEiQ3U3N0.

PTM databases

PhosphoSiteiQ3U3N0.

Expressioni

Gene expression databases

BgeeiQ3U3N0.
ExpressionAtlasiQ3U3N0. baseline and differential.
GenevisibleiQ3U3N0. MM.

Interactioni

Subunit structurei

Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.By similarity

Protein-protein interaction databases

BioGridi214043. 1 interaction.
STRINGi10090.ENSMUSP00000059864.

Structurei

3D structure databases

ProteinModelPortaliQ3U3N0.
SMRiQ3U3N0. Positions 195-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 29198ELM2PROSITE-ProRule annotationAdd
BLAST
Domaini296 – 34853SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ3U3N0.
OMAiWDPNILP.
OrthoDBiEOG7HQN7T.
PhylomeDBiQ3U3N0.
TreeFamiTF106453.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U3N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEASSLERQ SPRVASCLVH SLCPREPSLQ TTAVVSMGSA DHQFNLAELL
60 70 80 90 100
TQNYNLQEGC AEAPQCPDKP EEELDKDFID QSSDMPLDEL LALYGYESSD
110 120 130 140 150
PISEQESEGG DTAPALPDMT LDKEQIAKDL LSGEEEEETQ SSADDLTPSV
160 170 180 190 200
TSHEASDLFH NQSGSRFLAG DNGPGSSASS DTEEDALPAN KCKKEIMVGP
210 220 230 240 250
QFQADLNILH LNRHCDKIYE NEDQLLWSPS VLPEREVEEF LYRAVKRRWQ
260 270 280 290 300
EMAGPQIPEG EVVKDSEQAL YELVKCNFNV EEALRRLRFN VKVIRDGLCA
310 320 330 340 350
WSEEECRNFE HGFRVHGKNF HLIQANKVRT RSVGECVEYY YLWKKSERYD
360 370 380 390 400
YFAQQTRLGR RKFVSSGTTD TEQDLDGLDP DGHARLHSEA GVPVEPLNVD
410 420 430 440 450
IEAGGLDQPG VGSDDLPSSE PGPRPFQQLD EPPAVPSLQQ PTSLAASAEL
460 470 480 490 500
PPAAAAAPEP GTSPRLPVDL ALPEELPLVS SPVALSEDTA EPMAPAQVAL
510 520 530 540
SVTEFGLIGI GDVNPFLTGH PACPTSTLHS EPLSQCNVMT C
Length:541
Mass (Da):59,268
Last modified:October 11, 2005 - v1
Checksum:i8967FE4C67D3B815
GO
Isoform 2 (identifier: Q3U3N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-125: Missing.

Show »
Length:539
Mass (Da):59,010
Checksum:i7C914CEC74175CE1
GO
Isoform 3 (identifier: Q3U3N0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     124-125: Missing.
     390-397: Missing.

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):54,424
Checksum:i025ADDF0C7128C1E
GO

Sequence cautioni

The sequence BAD32406.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 3. 1 PublicationVSP_030096Add
BLAST
Alternative sequencei124 – 1252Missing in isoform 2 and isoform 3. 2 PublicationsVSP_030097
Alternative sequencei390 – 3978Missing in isoform 3. 1 PublicationVSP_030098

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154672 mRNA. Translation: BAE32755.1.
AK173128 mRNA. Translation: BAD32406.1. Different initiation.
BC067013 mRNA. Translation: AAH67013.2.
BC080757 mRNA. Translation: AAH80757.1.
BC083321 mRNA. Translation: AAH83321.1.
CCDSiCCDS48619.1. [Q3U3N0-2]
RefSeqiNP_001303628.1. NM_001316699.1. [Q3U3N0-1]
NP_081698.2. NM_027422.3. [Q3U3N0-2]
UniGeneiMm.334193.

Genome annotation databases

EnsembliENSMUST00000062855; ENSMUSP00000059864; ENSMUSG00000042570. [Q3U3N0-2]
ENSMUST00000165028; ENSMUSP00000127387; ENSMUSG00000042570. [Q3U3N0-1]
GeneIDi70427.
KEGGimmu:70427.
UCSCiuc007fyw.1. mouse. [Q3U3N0-2]
uc007fyy.1. mouse. [Q3U3N0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154672 mRNA. Translation: BAE32755.1.
AK173128 mRNA. Translation: BAD32406.1. Different initiation.
BC067013 mRNA. Translation: AAH67013.2.
BC080757 mRNA. Translation: AAH80757.1.
BC083321 mRNA. Translation: AAH83321.1.
CCDSiCCDS48619.1. [Q3U3N0-2]
RefSeqiNP_001303628.1. NM_001316699.1. [Q3U3N0-1]
NP_081698.2. NM_027422.3. [Q3U3N0-2]
UniGeneiMm.334193.

3D structure databases

ProteinModelPortaliQ3U3N0.
SMRiQ3U3N0. Positions 195-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214043. 1 interaction.
STRINGi10090.ENSMUSP00000059864.

PTM databases

PhosphoSiteiQ3U3N0.

Proteomic databases

EPDiQ3U3N0.
MaxQBiQ3U3N0.
PaxDbiQ3U3N0.
PRIDEiQ3U3N0.

Protocols and materials databases

DNASUi70427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062855; ENSMUSP00000059864; ENSMUSG00000042570. [Q3U3N0-2]
ENSMUST00000165028; ENSMUSP00000127387; ENSMUSG00000042570. [Q3U3N0-1]
GeneIDi70427.
KEGGimmu:70427.
UCSCiuc007fyw.1. mouse. [Q3U3N0-2]
uc007fyy.1. mouse. [Q3U3N0-1]

Organism-specific databases

CTDi54531.
MGIiMGI:1917677. Mier2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ3U3N0.
OMAiWDPNILP.
OrthoDBiEOG7HQN7T.
PhylomeDBiQ3U3N0.
TreeFamiTF106453.

Miscellaneous databases

PROiQ3U3N0.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U3N0.
ExpressionAtlasiQ3U3N0. baseline and differential.
GenevisibleiQ3U3N0. MM.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryonic intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiMIER2_MOUSE
AccessioniPrimary (citable) accession number: Q3U3N0
Secondary accession number(s): Q5XJI0
, Q66JU5, Q69ZP0, Q6NXL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.