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Q3U3J1

- Q3U3J1_MOUSE

UniProt

Q3U3J1 - Q3U3J1_MOUSE

Protein
Submitted name:

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Gene

Bckdha

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Source: InterPro

    GO - Biological processi

    1. response to cAMP Source: Ensembl
    2. response to glucocorticoid Source: Ensembl
    3. response to nutrient Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialImported
    Submitted name:
    Branched chain ketoacid dehydrogenase E1, alpha polypeptideImported
    Gene namesi
    Name:BckdhaImported
    ORF Names:mCG_7651Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107701. Bckdha.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3U3J1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000071292.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063174.
    HOGENOMiHOG000281337.
    HOVERGENiHBG002459.
    InParanoidiQ3U3J1.
    KOiK00166.
    OMAiQYKEHYP.
    OrthoDBiEOG7WT41H.
    TreeFamiTF300863.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3U3J1-1 [UniParc]FASTAAdd to Basket

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    MAIVMSAAKI WRPSRGLRQA ALLLLGRSGV RGLARSHPSR QQQQQFPSLD    50
    DKPQFPGASA EFVDKLEFIQ PNVISGIPIY RVMDRQGQII NPSEDPHLPQ 100
    EEVLKFYRSM TLLNTMDRIL YESQRQGRIS FYMTNYGEEG THVGSAAALE 150
    RTDLVFGQYR EAGVLMYRDY PLELFMSQCY GNVNDPGKGR QMPVHYGCKE 200
    RHFVTISSPL ATQIPQAVGA AYAAKRANAN RIVICYFGEG AASEGDAHAG 250
    FNFAATLECP IIFFCRNNGY AISTPTSEQY RGDGIAARGP GYGIMSIRVD 300
    GNDVFAVYNA TKEARRRAVA ENQPFLIEAM TYRIGHHSTS DDSSAYRSVD 350
    EVNYWDKQDH PISRLRQYLL NQGWWDEEQE KAWRKQSRKK VMEAFEQAER 400
    KLKPNPSLLF SDVYQEMPAQ LRRQQESLAR HLQTYGEHYP LDHFDK 446
    Length:446
    Mass (Da):50,773
    Last modified:October 11, 2005 - v1
    Checksum:i110D5F3FA8A3108D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC162614 Genomic DNA. No translation available.
    AK154734 mRNA. Translation: BAE32795.1.
    CH466593 Genomic DNA. Translation: EDL24248.1.
    RefSeqiNP_031559.3. NM_007533.5.
    UniGeneiMm.25848.

    Genome annotation databases

    EnsembliENSMUST00000071329; ENSMUSP00000071292; ENSMUSG00000060376.
    GeneIDi12039.
    KEGGimmu:12039.
    UCSCiuc009fth.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC162614 Genomic DNA. No translation available.
    AK154734 mRNA. Translation: BAE32795.1 .
    CH466593 Genomic DNA. Translation: EDL24248.1 .
    RefSeqi NP_031559.3. NM_007533.5.
    UniGenei Mm.25848.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000071292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071329 ; ENSMUSP00000071292 ; ENSMUSG00000060376 .
    GeneIDi 12039.
    KEGGi mmu:12039.
    UCSCi uc009fth.2. mouse.

    Organism-specific databases

    CTDi 593.
    MGIi MGI:107701. Bckdha.

    Phylogenomic databases

    GeneTreei ENSGT00530000063174.
    HOGENOMi HOG000281337.
    HOVERGENi HBG002459.
    InParanoidi Q3U3J1.
    KOi K00166.
    OMAi QYKEHYP.
    OrthoDBi EOG7WT41H.
    TreeFami TF300863.

    Miscellaneous databases

    NextBioi 280297.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3U3J1.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    14. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    15. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQ3U3J1_MOUSE
    AccessioniPrimary (citable) accession number: Q3U3J1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3