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Protein

Probable G-protein coupled receptor 160

Gene

Gpr160

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 160
Gene namesi
Name:Gpr160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1919112. Gpr160.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini42 – 5615CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9518ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini117 – 13620CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 18629ExtracellularSequence analysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini208 – 24336CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini265 – 2728ExtracellularSequence analysis
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 33643CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Probable G-protein coupled receptor 160PRO_0000069644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3U3F9.
PRIDEiQ3U3F9.

PTM databases

PhosphoSiteiQ3U3F9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037661.
CleanExiMM_GPR160.
ExpressionAtlasiQ3U3F9. baseline and differential.
GenevisibleiQ3U3F9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045165.

Structurei

3D structure databases

ProteinModelPortaliQ3U3F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK2K. Eukaryota.
ENOG410YX66. LUCA.
GeneTreeiENSGT00390000015520.
HOGENOMiHOG000112776.
HOVERGENiHBG062414.
InParanoidiQ3U3F9.
KOiK08438.
OMAiEMNVPWL.
OrthoDBiEOG091G0XC8.
PhylomeDBiQ3U3F9.
TreeFamiTF335541.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U3F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALSSKNCS LQYQLHQSPQ LLEASCLLFL IILGKVLLNI LLLRVRRGDA
60 70 80 90 100
RWTLMEYFCF SLALVDLLLL VNISILTYFR DFVVLGIRFT RYHICLLTQI
110 120 130 140 150
ISFTYGFLHY PVCSLACIDY WCNLSRASKQ SSRWQKLLYF LTVILTWISV
160 170 180 190 200
LAYVLVDPAI SVSLKAHRGY VYQCPAYVST QSHWLSLSML MVLFVAFLIS
210 220 230 240 250
WQEVVALLQA MRIASYKSKA ALYFPFPLHC GYALSCREAL LPRLIVCFLG
260 270 280 290 300
TWFPFVALQV LILSLRVQIP AYIEMNVPWL YFVNSFLIAA VYWFNCHKLD
310 320 330
LRDSSLPVDP FINWKCCFVP VHRLKQVERP MSIVIC
Length:336
Mass (Da):38,922
Last modified:October 11, 2005 - v1
Checksum:iE2AF0DCB28B36B95
GO

Sequence cautioni

The sequence BAB24531 differs from that shown. Reason: Frameshift at position 300. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211L → F in BAB24531 (PubMed:16141072).Curated
Sequence conflicti183 – 1831H → R in BAB24531 (PubMed:16141072).Curated
Sequence conflicti203 – 2031E → K in BAB24531 (PubMed:16141072).Curated
Sequence conflicti207 – 2082LL → VF in BAB24531 (PubMed:16141072).Curated
Sequence conflicti300 – 3001D → I in BAB24531 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006330 mRNA. Translation: BAB24531.1. Frameshift.
AK154620 mRNA. Translation: BAE32719.1.
AK154784 mRNA. Translation: BAE32827.1.
CCDSiCCDS50883.1.
RefSeqiNP_001127857.1. NM_001134385.2.
NP_001127858.1. NM_001134386.2.
NP_001273923.1. NM_001286994.1.
NP_001273924.1. NM_001286995.1.
NP_001273925.1. NM_001286996.1.
NP_082241.1. NM_027965.2.
XP_006535600.1. XM_006535537.2.
XP_006535602.1. XM_006535539.1.
UniGeneiMm.272019.

Genome annotation databases

EnsembliENSMUST00000046748; ENSMUSP00000045165; ENSMUSG00000037661.
ENSMUST00000108258; ENSMUSP00000103893; ENSMUSG00000037661.
ENSMUST00000108259; ENSMUSP00000103894; ENSMUSG00000037661.
ENSMUST00000108261; ENSMUSP00000103896; ENSMUSG00000037661.
ENSMUST00000166278; ENSMUSP00000128666; ENSMUSG00000037661.
GeneIDi71862.
KEGGimmu:71862.
UCSCiuc008ovi.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006330 mRNA. Translation: BAB24531.1. Frameshift.
AK154620 mRNA. Translation: BAE32719.1.
AK154784 mRNA. Translation: BAE32827.1.
CCDSiCCDS50883.1.
RefSeqiNP_001127857.1. NM_001134385.2.
NP_001127858.1. NM_001134386.2.
NP_001273923.1. NM_001286994.1.
NP_001273924.1. NM_001286995.1.
NP_001273925.1. NM_001286996.1.
NP_082241.1. NM_027965.2.
XP_006535600.1. XM_006535537.2.
XP_006535602.1. XM_006535539.1.
UniGeneiMm.272019.

3D structure databases

ProteinModelPortaliQ3U3F9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045165.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ3U3F9.

Proteomic databases

PaxDbiQ3U3F9.
PRIDEiQ3U3F9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046748; ENSMUSP00000045165; ENSMUSG00000037661.
ENSMUST00000108258; ENSMUSP00000103893; ENSMUSG00000037661.
ENSMUST00000108259; ENSMUSP00000103894; ENSMUSG00000037661.
ENSMUST00000108261; ENSMUSP00000103896; ENSMUSG00000037661.
ENSMUST00000166278; ENSMUSP00000128666; ENSMUSG00000037661.
GeneIDi71862.
KEGGimmu:71862.
UCSCiuc008ovi.3. mouse.

Organism-specific databases

CTDi26996.
MGIiMGI:1919112. Gpr160.

Phylogenomic databases

eggNOGiENOG410IK2K. Eukaryota.
ENOG410YX66. LUCA.
GeneTreeiENSGT00390000015520.
HOGENOMiHOG000112776.
HOVERGENiHBG062414.
InParanoidiQ3U3F9.
KOiK08438.
OMAiEMNVPWL.
OrthoDBiEOG091G0XC8.
PhylomeDBiQ3U3F9.
TreeFamiTF335541.

Miscellaneous databases

PROiQ3U3F9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037661.
CleanExiMM_GPR160.
ExpressionAtlasiQ3U3F9. baseline and differential.
GenevisibleiQ3U3F9. MM.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP160_MOUSE
AccessioniPrimary (citable) accession number: Q3U3F9
Secondary accession number(s): Q9D9Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.