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Protein
Submitted name:

Putative uncharacterized protein

Gene

Sorl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP-ribosylation factor binding Source: MGI
  2. beta-amyloid binding Source: MGI
  3. low-density lipoprotein particle binding Source: MGI

GO - Biological processi

  1. cell migration Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: MGI
  4. negative regulation of beta-amyloid formation Source: MGI
  5. negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: MGI
  6. negative regulation of protein binding Source: MGI
  7. negative regulation of protein oligomerization Source: MGI
  8. positive regulation of early endosome to recycling endosome transport Source: MGI
  9. positive regulation of endocytic recycling Source: MGI
  10. positive regulation of ER to Golgi vesicle-mediated transport Source: MGI
  11. positive regulation of protein catabolic process Source: MGI
  12. positive regulation of protein exit from endoplasmic reticulum Source: MGI
  13. positive regulation of protein localization to early endosome Source: MGI
  14. post-Golgi vesicle-mediated transport Source: MGI
  15. protein maturation Source: MGI
  16. protein retention in Golgi apparatus Source: MGI
  17. protein targeting Source: MGI
  18. protein targeting to Golgi Source: MGI
  19. protein targeting to lysosome Source: MGI
  20. regulation of smooth muscle cell migration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Sorl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1202296. Sorl1.

Subcellular locationi

GO - Cellular componenti

  1. early endosome Source: MGI
  2. endoplasmic reticulum Source: MGI
  3. endosome Source: MGI
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: MGI
  6. Golgi apparatus Source: MGI
  7. Golgi cisterna Source: MGI
  8. integral component of membrane Source: UniProtKB-KW
  9. membrane Source: MGI
  10. multivesicular body Source: Ensembl
  11. neuronal cell body Source: Ensembl
  12. nuclear envelope lumen Source: MGI
  13. perinuclear region of cytoplasm Source: MGI
  14. recycling endosome Source: MGI
  15. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ3U2X9.
ExpressionAtlasiQ3U2X9. baseline and differential.
GenevestigatoriQ3U2X9.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

InterProiIPR006581. VPS10.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3U2X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRSSRRES RLPFLFALVA LLPRGALGGG WTQRLHGGPA PLPQDRGFFV
60 70 80 90 100
VQGDPRDLRL GTHGDAPGAS PAARKPLRTR RSAALQPQPI QVYGQVSLND
110 120 130 140 150
SHNQMVVHWA GEKSNVIVAL ARDSLALARP KSSDVYVSYD YGKSFSKISE
160 170 180 190 200
KLNFGVGNNS EAVISQFYHS PADNKRYIFV DAYAQYLWIT FDFCSTIHGF
210 220 230 240 250
SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT WIMIQEHVKS
260 270 280 290 300
FSWGIDPYDQ PNAIYIERHE PFGFSTVLRS TDFFQSRENQ EVILEEVRDF
310 320 330 340 350
QLRDKYMFAT KVVHLPGSQQ QSSVQLWVSF GRKPMRAAQF VTKHPINEYY
360 370 380 390 400
IADAAEDQVF VCVSHSNNST NLYISEAEGL KFSLSLENVL YYSPGGAGSD
410 420 430 440 450
TLVRYFANEP FADFHRVEGL QGVYIATLIN GSMNEENMRS VITFDKGGTW
460 470 480 490 500
EFLQAPAFTG YGEKINCELS QGCSLHLAQR LSQLLNLQLR RMPILSKESA
510 520 530 540 550
PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY TWGDHGGIIM
560 570 580 590 600
AIAQGMETNE LKYSTNEGET WKTFVFSEKP VFVYGLLTEP GEKSTVFTIF
610 620 630 640 650
GSNKESVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV
660 670 680 690 700
FKRRTPHATC FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV
710 720 730 740 750
PDPEFSGKPY SPPVPCPVGS SYRRTRGYRK ISGDTCSGGD VEARLEGELV
760 770 780
PCPLAEENEF ILYAMRKSIY RYDLASGATE
Length:780
Mass (Da):87,209
Last modified:October 11, 2005 - v1
Checksum:i948AFA9BBC8BAD07
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei780 – 7801Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155045 mRNA. Translation: BAE33011.1.
UniGeneiMm.121920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155045 mRNA. Translation: BAE33011.1.
UniGeneiMm.121920.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1202296. Sorl1.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3U2X9.
ExpressionAtlasiQ3U2X9. baseline and differential.
GenevestigatoriQ3U2X9.

Family and domain databases

InterProiIPR006581. VPS10.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U2X9_MOUSE
AccessioniPrimary (citable) accession number: Q3U2X9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.