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Protein

8-oxo-dGDP phosphatase NUDT18

Gene

Nudt18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).By similarity

Catalytic activityi

8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Magnesium or manganeseBy similarity1
Metal bindingi95Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2393930. Phosphate bond hydrolysis by NUDT proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
8-oxo-dGDP phosphatase NUDT18 (EC:3.6.1.58)
Alternative name(s):
2-hydroxy-dADP phosphatase
7,8-dihydro-8-oxoguanine phosphatase
MutT homolog 3
Nucleoside diphosphate-linked moiety X motif 18
Short name:
Nudix motif 18
Gene namesi
Name:Nudt18
Synonyms:Mth3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2385853. Nudt18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245681 – 3238-oxo-dGDP phosphatase NUDT18Add BLAST323

Proteomic databases

MaxQBiQ3U2V3.
PaxDbiQ3U2V3.
PRIDEiQ3U2V3.

PTM databases

PhosphoSitePlusiQ3U2V3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045211.
GenevisibleiQ3U2V3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086450.

Structurei

3D structure databases

ProteinModelPortaliQ3U2V3.
SMRiQ3U2V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 167Nudix hydrolasePROSITE-ProRule annotationAdd BLAST131

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 97Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IN6N. Eukaryota.
ENOG41102IB. LUCA.
GeneTreeiENSGT00390000002931.
HOGENOMiHOG000035136.
HOVERGENiHBG108203.
InParanoidiQ3U2V3.
KOiK17817.
OMAiGENFFWW.
OrthoDBiEOG091G0XZN.
PhylomeDBiQ3U2V3.
TreeFamiTF106355.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U2V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATEGLAGAL ATVLGGKGLL VQSCDSEPAG KPLFPVRLRK NVCYVVLAVF
60 70 80 90 100
LNEQDEVLMI QEAKRECRGT WYLPAGRMEP GETIVEAMQR EVKEEAGLLC
110 120 130 140 150
EPVTLLSVEE RGASWIRFVF LARPTGGVLK TSKDADSESL QAGWYPRVSL
160 170 180 190 200
PTPLRAHDVL HLVELGAKFC QQAMHPLILP QELPCSVVCQ RLVTTFTTVQ
210 220 230 240 250
SVWVLVGTVG TPHLPITACG FTPMEQRGGI KVAILRLLQE CLTLHSLAVE
260 270 280 290 300
TKGLLGLQHL GRDHVDGVCL NVLVTVAFRN PGIQDEPPKI RGENYFWWKV
310 320
LEEDLQKLLL YRLQESSVIP LSR
Length:323
Mass (Da):35,694
Last modified:October 11, 2005 - v1
Checksum:i6056DF1DB350CF9F
GO
Isoform 2 (identifier: Q3U2V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):27,362
Checksum:iAEC44BBE84358DE4
GO
Isoform 3 (identifier: Q3U2V3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):16,788
Checksum:i952FE84AB1DA6B1A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0322781 – 173Missing in isoform 3. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_0322791 – 77Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089446 mRNA. Translation: BAC40887.1.
AK145997 mRNA. Translation: BAE26818.1.
AK155086 mRNA. Translation: BAE33037.1.
AK157937 mRNA. Translation: BAE34271.1.
BC036718 mRNA. Translation: AAH36718.1.
CCDSiCCDS27258.1. [Q3U2V3-1]
RefSeqiNP_694776.2. NM_153136.4. [Q3U2V3-1]
XP_006518856.1. XM_006518793.2. [Q3U2V3-2]
UniGeneiMm.34191.

Genome annotation databases

EnsembliENSMUST00000089049; ENSMUSP00000086450; ENSMUSG00000045211. [Q3U2V3-1]
GeneIDi213484.
KEGGimmu:213484.
UCSCiuc007uok.1. mouse. [Q3U2V3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089446 mRNA. Translation: BAC40887.1.
AK145997 mRNA. Translation: BAE26818.1.
AK155086 mRNA. Translation: BAE33037.1.
AK157937 mRNA. Translation: BAE34271.1.
BC036718 mRNA. Translation: AAH36718.1.
CCDSiCCDS27258.1. [Q3U2V3-1]
RefSeqiNP_694776.2. NM_153136.4. [Q3U2V3-1]
XP_006518856.1. XM_006518793.2. [Q3U2V3-2]
UniGeneiMm.34191.

3D structure databases

ProteinModelPortaliQ3U2V3.
SMRiQ3U2V3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086450.

PTM databases

PhosphoSitePlusiQ3U2V3.

Proteomic databases

MaxQBiQ3U2V3.
PaxDbiQ3U2V3.
PRIDEiQ3U2V3.

Protocols and materials databases

DNASUi213484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089049; ENSMUSP00000086450; ENSMUSG00000045211. [Q3U2V3-1]
GeneIDi213484.
KEGGimmu:213484.
UCSCiuc007uok.1. mouse. [Q3U2V3-1]

Organism-specific databases

CTDi79873.
MGIiMGI:2385853. Nudt18.

Phylogenomic databases

eggNOGiENOG410IN6N. Eukaryota.
ENOG41102IB. LUCA.
GeneTreeiENSGT00390000002931.
HOGENOMiHOG000035136.
HOVERGENiHBG108203.
InParanoidiQ3U2V3.
KOiK17817.
OMAiGENFFWW.
OrthoDBiEOG091G0XZN.
PhylomeDBiQ3U2V3.
TreeFamiTF106355.

Enzyme and pathway databases

ReactomeiR-MMU-2393930. Phosphate bond hydrolysis by NUDT proteins.

Miscellaneous databases

PROiQ3U2V3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045211.
GenevisibleiQ3U2V3. MM.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUD18_MOUSE
AccessioniPrimary (citable) accession number: Q3U2V3
Secondary accession number(s): Q8C223, Q8K1Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.