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Protein
Submitted name:

Putative uncharacterized protein

Gene

Mapkapk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. 3'-UTR-mediated mRNA stabilization Source: MGI
  2. cellular response to DNA damage stimulus Source: MGI
  3. cellular response to vascular endothelial growth factor stimulus Source: MGI
  4. G2 DNA damage checkpoint Source: Ensembl
  5. inner ear development Source: MGI
  6. mRNA stabilization Source: MGI
  7. peptidyl-serine phosphorylation Source: MGI
  8. regulation of tumor necrosis factor production Source: MGI
  9. response to cytokine Source: MGI
  10. vascular endothelial growth factor receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Mapkapk2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109298. Mapkapk2.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. nucleoplasm Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ3U2P8.

Expressioni

Gene expression databases

BgeeiQ3U2P8.
ExpressionAtlasiQ3U2P8. baseline and differential.
GenevestigatoriQ3U2P8.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ3U2P8.
SMRiQ3U2P8. Positions 37-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00780000121860.
HOVERGENiHBG106948.
KOiK04443.
OMAiLQMLQDC.
PhylomeDBiQ3U2P8.

Family and domain databases

Gene3Di4.10.1170.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027442. MAPKAPK_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U2P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSGSPGQTP PAPFPSPPPP APAQPPPPFP QFHVKSGLQI RKNAITDDYK
60 70 80 90 100
VTSQVLGLGI NGKVLRIFDK RTQQKFALKM LQDCPKARRE VELHWRASQC
110 120 130 140 150
PHIVHIVDVY ENLYAGRKCL LIVMECLDGG ELFSRIQDRG DQAFTEREAS
160 170 180 190 200
EIMKSIGEAI QYLHSINIAH RDVKPENLLY TSKRPNAILK LTDFGFAKET
210 220 230 240 250
TSHNSLTTPC YTPYYVAPEV LGPEKYDKSC DMWSLGVIMY ILLCGYPPFY
260 270 280 290 300
SNHGLAISPG MKTRIRMGQY EFPNPEWSEV SEEVKMLIRN LLKTEPTQRM
310 320 330 340 350
TITEFMNHPW IMQSTKVPQT PLHTSRVLKE DKERWEDVKE EMTSALATMR
360 370 380
VDYEQIKIKK IEDASNPLLL KRRKKARAVE DAALAH
Length:386
Mass (Da):44,050
Last modified:October 10, 2005 - v1
Checksum:iED7827641A826BF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155171 mRNA. Translation: BAE33092.1.
RefSeqiNP_032577.1. NM_008551.1.
UniGeneiMm.221235.
Mm.490983.

Genome annotation databases

GeneIDi17164.
KEGGimmu:17164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155171 mRNA. Translation: BAE33092.1.
RefSeqiNP_032577.1. NM_008551.1.
UniGeneiMm.221235.
Mm.490983.

3D structure databases

ProteinModelPortaliQ3U2P8.
SMRiQ3U2P8. Positions 37-376.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ3U2P8.

Proteomic databases

PRIDEiQ3U2P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17164.
KEGGimmu:17164.

Organism-specific databases

CTDi9261.
MGIiMGI:109298. Mapkapk2.

Phylogenomic databases

GeneTreeiENSGT00780000121860.
HOVERGENiHBG106948.
KOiK04443.
OMAiLQMLQDC.
PhylomeDBiQ3U2P8.

Miscellaneous databases

ChiTaRSiMapkapk2. mouse.
NextBioi291442.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U2P8.
ExpressionAtlasiQ3U2P8. baseline and differential.
GenevestigatoriQ3U2P8.

Family and domain databases

Gene3Di4.10.1170.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR027442. MAPKAPK_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U2P8_MOUSE
AccessioniPrimary (citable) accession number: Q3U2P8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 10, 2005
Last sequence update: October 10, 2005
Last modified: March 3, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.