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Protein

Calmodulin-lysine N-methyltransferase

Gene

Camkmt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the trimethylation of 'Lys-116' in calmodulin.By similarity

Catalytic activityi

S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N(6)-methyl-L-lysine.PROSITE-ProRule annotation

GO - Molecular functioni

  • calmodulin-lysine N-methyltransferase activity Source: MGI

GO - Biological processi

  • mitochondrion organization Source: MGI
  • peptidyl-lysine methylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-lysine N-methyltransferase (EC:2.1.1.60)
Short name:
CLNMT
Short name:
CaM KMT
Gene namesi
Name:Camkmt
Synonyms:Clnmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1920832. Camkmt.

Subcellular locationi

Isoform 1 :
  • Cytoplasm By similarity
  • Nucleus By similarity
Isoform 2 :
  • Golgi apparatus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Calmodulin-lysine N-methyltransferasePRO_0000300116Add
BLAST

Proteomic databases

MaxQBiQ3U2J5.
PaxDbiQ3U2J5.
PRIDEiQ3U2J5.

PTM databases

iPTMnetiQ3U2J5.
PhosphoSiteiQ3U2J5.

Expressioni

Tissue specificityi

Detected in most of the tissues examined, with the highest expression in the brain and muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000071037.
CleanExiMM_1700106N22RIK.
ExpressionAtlasiQ3U2J5. baseline and differential.
GenevisibleiQ3U2J5. MM.

Interactioni

Subunit structurei

Monomer. Interacts with HSP90, probably as a client (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092811.

Structurei

3D structure databases

ProteinModelPortaliQ3U2J5.
SMRiQ3U2J5. Positions 61-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3201. Eukaryota.
ENOG4110DEX. LUCA.
GeneTreeiENSGT00390000002168.
HOVERGENiHBG105701.
InParanoidiQ3U2J5.
KOiK18826.
OMAiFQDECVA.
OrthoDBiEOG091G0FGE.
PhylomeDBiQ3U2J5.
TreeFamiTF316589.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025800. CaM-Lys-N-MeTrfase.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51610. SAM_CLNMT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U2J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESQVAAAGA AETEAEAGKR PAMGSASQGS LVSAPKGAVR WQLLRQVLKQ
60 70 80 90 100
KQLDDHLRHV SVRRFESFNL FSVTEATKKG TEKEAGVWVQ YTSIFYPKYS
110 120 130 140 150
ISVRHNSGSL NVEDVLTSFD NTGNVCIWPS EEVLAHYCLK HSHIFRDLAV
160 170 180 190 200
CELGGGMTCL AGLMVAISAD VKEVLLTDGN EKAIRNVDSI IACNKKTGVF
210 220 230 240 250
KTPKISSRVL RWDNETDVSQ LEGHFDIVMC ADCLFLDQYR ASLVDAIKRL
260 270 280 290 300
LQPTGKAVVF APRRGNTFNQ FCNLAEKAGF SLQRHENYDE PISNFHSKLK
310 320
KEGSDIYEEN LHYPLLLILT KTG
Length:323
Mass (Da):35,887
Last modified:October 11, 2005 - v1
Checksum:i26EF97905B6790CD
GO
Isoform 2 (identifier: Q3U2J5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-145: IWPSEEVLAHYCLKHSHIF → DPPPAPHTGGVDGDVFLTT
     146-323: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):15,666
Checksum:iF75B04168A488F00
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 14519IWPSE…HSHIF → DPPPAPHTGGVDGDVFLTT in isoform 2. 1 PublicationVSP_027786Add
BLAST
Alternative sequencei146 – 323178Missing in isoform 2. 1 PublicationVSP_027787Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007130 mRNA. Translation: BAB24867.1.
AK155246 mRNA. Translation: BAE33145.1.
CCDSiCCDS37712.1. [Q3U2J5-1]
RefSeqiNP_082852.1. NM_028576.2. [Q3U2J5-1]
UniGeneiMm.260753.
Mm.441531.

Genome annotation databases

EnsembliENSMUST00000095188; ENSMUSP00000092811; ENSMUSG00000071037. [Q3U2J5-1]
GeneIDi73582.
KEGGimmu:73582.
UCSCiuc008dtt.1. mouse. [Q3U2J5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007130 mRNA. Translation: BAB24867.1.
AK155246 mRNA. Translation: BAE33145.1.
CCDSiCCDS37712.1. [Q3U2J5-1]
RefSeqiNP_082852.1. NM_028576.2. [Q3U2J5-1]
UniGeneiMm.260753.
Mm.441531.

3D structure databases

ProteinModelPortaliQ3U2J5.
SMRiQ3U2J5. Positions 61-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092811.

PTM databases

iPTMnetiQ3U2J5.
PhosphoSiteiQ3U2J5.

Proteomic databases

MaxQBiQ3U2J5.
PaxDbiQ3U2J5.
PRIDEiQ3U2J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095188; ENSMUSP00000092811; ENSMUSG00000071037. [Q3U2J5-1]
GeneIDi73582.
KEGGimmu:73582.
UCSCiuc008dtt.1. mouse. [Q3U2J5-1]

Organism-specific databases

CTDi79823.
MGIiMGI:1920832. Camkmt.

Phylogenomic databases

eggNOGiKOG3201. Eukaryota.
ENOG4110DEX. LUCA.
GeneTreeiENSGT00390000002168.
HOVERGENiHBG105701.
InParanoidiQ3U2J5.
KOiK18826.
OMAiFQDECVA.
OrthoDBiEOG091G0FGE.
PhylomeDBiQ3U2J5.
TreeFamiTF316589.

Enzyme and pathway databases

ReactomeiR-MMU-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

PROiQ3U2J5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071037.
CleanExiMM_1700106N22RIK.
ExpressionAtlasiQ3U2J5. baseline and differential.
GenevisibleiQ3U2J5. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025800. CaM-Lys-N-MeTrfase.
IPR019410. Methyltransf_16.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51610. SAM_CLNMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMKMT_MOUSE
AccessioniPrimary (citable) accession number: Q3U2J5
Secondary accession number(s): Q9D9C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.