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Q3U2I0

- Q3U2I0_MOUSE

UniProt

Q3U2I0 - Q3U2I0_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene
Irs2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phosphatidylinositol 3-kinase binding Source: MGI
  2. protein kinase binding Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. cell proliferation Source: MGI
  3. cellular response to insulin stimulus Source: MGI
  4. insulin receptor signaling pathway Source: MGI
  5. mammary gland development Source: MGI
  6. positive regulation of cell migration Source: MGI
  7. positive regulation of cell proliferation Source: MGI
  8. positive regulation of mesenchymal cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Irs2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109334. Irs2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3U2I0.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000542.
InParanoidiQ3U2I0.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
PRINTSiPR00628. INSULINRSI.
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3U2I0-1 [UniParc]FASTAAdd to Basket

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SAAGGSPPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK     50
YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRSGE GGSGTTGGSC 100
SASLPGVLGG SAGAAGCDDN YGLVTPATAV YREVWQVNLK PKGLGQSKNL 150
TGVYRLCLSA RTIGFVKLNC EQPSVTLQLM NIRRCGHSDS FFFIEVGRSA 200
VTGPGELWMQ ADDSVVAQNI HETILEAMKA LKELFEFRPR SKSQSSGSSA 250
THPISVPGAR RHHHLVNLPP SQTGLVRRSR TDSLAATPPA AKCTSCRVRT 300
ASEGDGGAAG GAGTAGGRPM SVAGSPLSPG PVRAPLSRSH TLSAGCGGRP 350
SKVTLAPAGG ALQHSRSMSM PVAHSPPAAT SPGSLSSSSG HGSGSYPLPP 400
GSHPHLPHPL HHPQGQRPSS GSASASGSPS DPGFMSLDEY GSSPGDLRAF 450
SSHRSNTPES IAETPPARDG SGGELYGYMS MDRPLSHCGR PYRRVSGDGA 500
QDLDRGLRKR TYSLTTPARQ RQVPQPSSAS LDEYTLMRAT FSGSSGRLCP 550
SFPASSPKVA YNPYPEDYGD IEIGSHKSSS SNLGADDGYM PMTPGAALRS 600
GGPNSCKSDD YMPMSPTSVS APKQILQPRL AAALPPSGAA VPAPPSGVGR 650
TFPVNGGGYK ASSPAESSPE ESGYMRMWCG SKLSMENPDP KLLPNGDYLN 700
MSPSEAGTAG TPPDFSAALR GGSEGLKGIP GHCYSSLPRS YKAPCSCSGD 750
DDQYVLMSSP VGRILEEERL EPQATPGAGT FGAAGGSHTQ PHHSAVPSSM 800
RPSAIGGRPE GFLGQRCRAV RPTRLSLEGL QTLPSMQEYP LPTEPKSPGE 850
YINIDFGEAG TRLSPPAPPL LASAASSSSL LSASSPASSL GSGTPGTSSD 900
SRQRSPLSDY MNLDFSSPKS PKPSTRSGDT VGSMDGLLSP EDSSPYPPLP 950
PRLPLPPSSL QQPLPPAPGD LYRLPPASAA XSQGPTAGSS MSSEPGDNGD 1000
YTEMAFGVAA TPPQPIVAPP KPEGARVASP TSGLKRLSLM DQVSGVEAFL 1050
QVSQPPDPHR GAKVIRADPQ GGRRRHSSET FSSTTTVTPV SPSFAHNSKR 1100
HNSASVENVS LRKSREGSST LGGGDEPPTS PGQAQPLVAV PPVPQARPWN 1150
PGQPGALIGC PGGSSSPMRR ETSVGFQNGL NYIAIDVRGE QGSLAQSQPQ 1200
PGDKNSWSRT RSLGGLLGTV GGSGASGVCG GPGTGALPSA STYASIDFLS 1250
HHLKEATVVK E 1261
Length:1,261
Mass (Da):130,673
Last modified:October 11, 2005 - v1
Checksum:i7F846778685CCB2A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK155277 mRNA. Translation: BAE33160.1.
UniGeneiMm.407207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK155277 mRNA. Translation: BAE33160.1 .
UniGenei Mm.407207.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:109334. Irs2.

Phylogenomic databases

HOVERGENi HBG000542.
InParanoidi Q3U2I0.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q3U2I0.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
[Graphical view ]
PRINTSi PR00628. INSULINRSI.
SMARTi SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U2I0_MOUSE
AccessioniPrimary (citable) accession number: Q3U2I0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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