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Q3U2I0

- Q3U2I0_MOUSE

UniProt

Q3U2I0 - Q3U2I0_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Irs2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. phosphatidylinositol 3-kinase binding Source: MGI
  2. protein kinase binding Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. cell proliferation Source: MGI
  3. cellular response to insulin stimulus Source: MGI
  4. insulin receptor signaling pathway Source: MGI
  5. mammary gland development Source: MGI
  6. positive regulation of cell migration Source: MGI
  7. positive regulation of cell proliferation Source: MGI
  8. positive regulation of mesenchymal cell proliferation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Irs2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:109334. Irs2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3U2I0.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000542.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
PRINTSiPR00628. INSULINRSI.
SMARTiSM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3U2I0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
SAAGGSPPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK
60 70 80 90 100
YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRSGE GGSGTTGGSC
110 120 130 140 150
SASLPGVLGG SAGAAGCDDN YGLVTPATAV YREVWQVNLK PKGLGQSKNL
160 170 180 190 200
TGVYRLCLSA RTIGFVKLNC EQPSVTLQLM NIRRCGHSDS FFFIEVGRSA
210 220 230 240 250
VTGPGELWMQ ADDSVVAQNI HETILEAMKA LKELFEFRPR SKSQSSGSSA
260 270 280 290 300
THPISVPGAR RHHHLVNLPP SQTGLVRRSR TDSLAATPPA AKCTSCRVRT
310 320 330 340 350
ASEGDGGAAG GAGTAGGRPM SVAGSPLSPG PVRAPLSRSH TLSAGCGGRP
360 370 380 390 400
SKVTLAPAGG ALQHSRSMSM PVAHSPPAAT SPGSLSSSSG HGSGSYPLPP
410 420 430 440 450
GSHPHLPHPL HHPQGQRPSS GSASASGSPS DPGFMSLDEY GSSPGDLRAF
460 470 480 490 500
SSHRSNTPES IAETPPARDG SGGELYGYMS MDRPLSHCGR PYRRVSGDGA
510 520 530 540 550
QDLDRGLRKR TYSLTTPARQ RQVPQPSSAS LDEYTLMRAT FSGSSGRLCP
560 570 580 590 600
SFPASSPKVA YNPYPEDYGD IEIGSHKSSS SNLGADDGYM PMTPGAALRS
610 620 630 640 650
GGPNSCKSDD YMPMSPTSVS APKQILQPRL AAALPPSGAA VPAPPSGVGR
660 670 680 690 700
TFPVNGGGYK ASSPAESSPE ESGYMRMWCG SKLSMENPDP KLLPNGDYLN
710 720 730 740 750
MSPSEAGTAG TPPDFSAALR GGSEGLKGIP GHCYSSLPRS YKAPCSCSGD
760 770 780 790 800
DDQYVLMSSP VGRILEEERL EPQATPGAGT FGAAGGSHTQ PHHSAVPSSM
810 820 830 840 850
RPSAIGGRPE GFLGQRCRAV RPTRLSLEGL QTLPSMQEYP LPTEPKSPGE
860 870 880 890 900
YINIDFGEAG TRLSPPAPPL LASAASSSSL LSASSPASSL GSGTPGTSSD
910 920 930 940 950
SRQRSPLSDY MNLDFSSPKS PKPSTRSGDT VGSMDGLLSP EDSSPYPPLP
960 970 980 990 1000
PRLPLPPSSL QQPLPPAPGD LYRLPPASAA XSQGPTAGSS MSSEPGDNGD
1010 1020 1030 1040 1050
YTEMAFGVAA TPPQPIVAPP KPEGARVASP TSGLKRLSLM DQVSGVEAFL
1060 1070 1080 1090 1100
QVSQPPDPHR GAKVIRADPQ GGRRRHSSET FSSTTTVTPV SPSFAHNSKR
1110 1120 1130 1140 1150
HNSASVENVS LRKSREGSST LGGGDEPPTS PGQAQPLVAV PPVPQARPWN
1160 1170 1180 1190 1200
PGQPGALIGC PGGSSSPMRR ETSVGFQNGL NYIAIDVRGE QGSLAQSQPQ
1210 1220 1230 1240 1250
PGDKNSWSRT RSLGGLLGTV GGSGASGVCG GPGTGALPSA STYASIDFLS
1260
HHLKEATVVK E
Length:1,261
Mass (Da):130,673
Last modified:October 11, 2005 - v1
Checksum:i7F846778685CCB2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155277 mRNA. Translation: BAE33160.1.
UniGeneiMm.407207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK155277 mRNA. Translation: BAE33160.1 .
UniGenei Mm.407207.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:109334. Irs2.

Phylogenomic databases

HOVERGENi HBG000542.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q3U2I0.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
[Graphical view ]
PRINTSi PR00628. INSULINRSI.
SMARTi SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.

Entry informationi

Entry nameiQ3U2I0_MOUSE
AccessioniPrimary (citable) accession number: Q3U2I0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)