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Q3U2I0

- Q3U2I0_MOUSE

UniProt

Q3U2I0 - Q3U2I0_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Irs2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatidylinositol 3-kinase binding Source: MGI
    2. protein kinase binding Source: MGI

    GO - Biological processi

    1. brain development Source: MGI
    2. cell proliferation Source: MGI
    3. cellular response to insulin stimulus Source: MGI
    4. insulin receptor signaling pathway Source: MGI
    5. mammary gland development Source: MGI
    6. positive regulation of cell migration Source: MGI
    7. positive regulation of cell proliferation Source: MGI
    8. positive regulation of mesenchymal cell proliferation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Irs2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:109334. Irs2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3U2I0.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG000542.
    InParanoidiQ3U2I0.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF02174. IRS. 1 hit.
    [Graphical view]
    PRINTSiPR00628. INSULINRSI.
    SMARTiSM00310. PTBI. 1 hit.
    [Graphical view]
    PROSITEiPS51064. IRS_PTB. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3U2I0-1 [UniParc]FASTAAdd to Basket

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    SAAGGSPPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK     50
    YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRSGE GGSGTTGGSC 100
    SASLPGVLGG SAGAAGCDDN YGLVTPATAV YREVWQVNLK PKGLGQSKNL 150
    TGVYRLCLSA RTIGFVKLNC EQPSVTLQLM NIRRCGHSDS FFFIEVGRSA 200
    VTGPGELWMQ ADDSVVAQNI HETILEAMKA LKELFEFRPR SKSQSSGSSA 250
    THPISVPGAR RHHHLVNLPP SQTGLVRRSR TDSLAATPPA AKCTSCRVRT 300
    ASEGDGGAAG GAGTAGGRPM SVAGSPLSPG PVRAPLSRSH TLSAGCGGRP 350
    SKVTLAPAGG ALQHSRSMSM PVAHSPPAAT SPGSLSSSSG HGSGSYPLPP 400
    GSHPHLPHPL HHPQGQRPSS GSASASGSPS DPGFMSLDEY GSSPGDLRAF 450
    SSHRSNTPES IAETPPARDG SGGELYGYMS MDRPLSHCGR PYRRVSGDGA 500
    QDLDRGLRKR TYSLTTPARQ RQVPQPSSAS LDEYTLMRAT FSGSSGRLCP 550
    SFPASSPKVA YNPYPEDYGD IEIGSHKSSS SNLGADDGYM PMTPGAALRS 600
    GGPNSCKSDD YMPMSPTSVS APKQILQPRL AAALPPSGAA VPAPPSGVGR 650
    TFPVNGGGYK ASSPAESSPE ESGYMRMWCG SKLSMENPDP KLLPNGDYLN 700
    MSPSEAGTAG TPPDFSAALR GGSEGLKGIP GHCYSSLPRS YKAPCSCSGD 750
    DDQYVLMSSP VGRILEEERL EPQATPGAGT FGAAGGSHTQ PHHSAVPSSM 800
    RPSAIGGRPE GFLGQRCRAV RPTRLSLEGL QTLPSMQEYP LPTEPKSPGE 850
    YINIDFGEAG TRLSPPAPPL LASAASSSSL LSASSPASSL GSGTPGTSSD 900
    SRQRSPLSDY MNLDFSSPKS PKPSTRSGDT VGSMDGLLSP EDSSPYPPLP 950
    PRLPLPPSSL QQPLPPAPGD LYRLPPASAA XSQGPTAGSS MSSEPGDNGD 1000
    YTEMAFGVAA TPPQPIVAPP KPEGARVASP TSGLKRLSLM DQVSGVEAFL 1050
    QVSQPPDPHR GAKVIRADPQ GGRRRHSSET FSSTTTVTPV SPSFAHNSKR 1100
    HNSASVENVS LRKSREGSST LGGGDEPPTS PGQAQPLVAV PPVPQARPWN 1150
    PGQPGALIGC PGGSSSPMRR ETSVGFQNGL NYIAIDVRGE QGSLAQSQPQ 1200
    PGDKNSWSRT RSLGGLLGTV GGSGASGVCG GPGTGALPSA STYASIDFLS 1250
    HHLKEATVVK E 1261
    Length:1,261
    Mass (Da):130,673
    Last modified:October 11, 2005 - v1
    Checksum:i7F846778685CCB2A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155277 mRNA. Translation: BAE33160.1.
    UniGeneiMm.407207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155277 mRNA. Translation: BAE33160.1 .
    UniGenei Mm.407207.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:109334. Irs2.

    Phylogenomic databases

    HOVERGENi HBG000542.
    InParanoidi Q3U2I0.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3U2I0.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF02174. IRS. 1 hit.
    [Graphical view ]
    PRINTSi PR00628. INSULINRSI.
    SMARTi SM00310. PTBI. 1 hit.
    [Graphical view ]
    PROSITEi PS51064. IRS_PTB. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.

    Entry informationi

    Entry nameiQ3U2I0_MOUSE
    AccessioniPrimary (citable) accession number: Q3U2I0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)