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Protein
Submitted name:

Heat shock 70 kDa protein 4

Gene

Hspa4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress responseImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Heat shock 70 kDa protein 4Imported
Submitted name:
Heat shock protein 4, isoform CRA_aImported
Gene namesi
Name:Hspa4Imported
ORF Names:mCG_113604Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1342292. Hspa4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000020361.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020630.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili605 – 629Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOVERGENiHBG047955.
KOiK09489.
OMAiDDRNTFT.
OrthoDBiEOG091G04Y6.
TreeFamiTF105043.

Family and domain databases

Gene3Di1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U2G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT
310 320 330 340 350
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
PISLRWNSPA EEGLSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV
510 520 530 540 550
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT PAENKAESEE
560 570 580 590 600
METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIESQLLWQ LDREMLGLYT
610 620 630 640 650
ENEGKMIMQD KLEKERNDAK NAVEEYVYEM RDKLSGEYEK FVSEDDRNTF
660 670 680 690 700
TLKLEDTENW LYEDGEDQPK QVYVDKLAEL KSLGQPIKTR FQESEERPKL
710 720 730 740 750
FEELGKQIQQ YMKVISSFKN KEDQYEHLDA ADVTKVEKST NEAMEWMNSK
760 770 780 790 800
LNLQNKQSLT VDPVVKTKEI EAKIKELTSI CSPIISKPKP KVEPPKEEPK
810 820 830 840
HAEQNGPVDG QGDNPGSQAA EHGADTAVPS DGDKKLPEMD ID
Length:842
Mass (Da):94,209
Last modified:February 5, 2008 - v1
Checksum:iDB1C399060569570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592489 Genomic DNA. No translation available.
AL596382 Genomic DNA. No translation available.
AK155305 mRNA. Translation: BAE33178.1.
CH466575 Genomic DNA. Translation: EDL33601.1.
RefSeqiNP_032326.3. NM_008300.3.
UniGeneiMm.239865.

Genome annotation databases

EnsembliENSMUST00000020630; ENSMUSP00000020630; ENSMUSG00000020361.
GeneIDi15525.
KEGGimmu:15525.
UCSCiuc007ivq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592489 Genomic DNA. No translation available.
AL596382 Genomic DNA. No translation available.
AK155305 mRNA. Translation: BAE33178.1.
CH466575 Genomic DNA. Translation: EDL33601.1.
RefSeqiNP_032326.3. NM_008300.3.
UniGeneiMm.239865.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020630; ENSMUSP00000020630; ENSMUSG00000020361.
GeneIDi15525.
KEGGimmu:15525.
UCSCiuc007ivq.1. mouse.

Organism-specific databases

CTDi3308.
MGIiMGI:1342292. Hspa4.

Phylogenomic databases

eggNOGiKOG0103. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000016919.
HOVERGENiHBG047955.
KOiK09489.
OMAiDDRNTFT.
OrthoDBiEOG091G04Y6.
TreeFamiTF105043.

Miscellaneous databases

ChiTaRSiHspa4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020361.

Family and domain databases

Gene3Di1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U2G2_MOUSE
AccessioniPrimary (citable) accession number: Q3U2G2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.