Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene

Lcorl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi543 – 56321H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent nuclear receptor corepressor-like protein
Short name:
LCoR-like protein
Alternative name(s):
Mblk1-related protein 1
Transcription factor MLR1
Gene namesi
Name:Lcorl
Synonyms:Mlr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2651932. Lcorl.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Ligand-dependent nuclear receptor corepressor-like proteinPRO_0000310464Add
BLAST

Proteomic databases

MaxQBiQ3U285.
PaxDbiQ3U285.
PRIDEiQ3U285.

PTM databases

iPTMnetiQ3U285.
PhosphoSiteiQ3U285.

Expressioni

Tissue specificityi

Expressed predominantly in the spermatocytes of the testis. Also found in the kidney, liver and heart.1 Publication

Gene expression databases

BgeeiQ3U285.
ExpressionAtlasiQ3U285. baseline and differential.
GenevisibleiQ3U285. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016026.

Structurei

3D structure databases

ProteinModelPortaliQ3U285.
SMRiQ3U285. Positions 521-578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini515 – 56753HTH psq-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 3022Ala-richAdd
BLAST

Sequence similaritiesi

Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4565. Eukaryota.
ENOG4111GCI. LUCA.
GeneTreeiENSGT00520000055615.
HOVERGENiHBG108084.
InParanoidiQ3U285.
OMAiYKVKERS.
OrthoDBiEOG7VHSXQ.
PhylomeDBiQ3U285.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U285-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKGRERMAA AAAAAAAAAA AQCRSPRCAA ERRGFRRELD SWRHRLMHCV
60 70 80 90 100
GFESILEGLY GPRLRRDLSL FEDCEPEELT DWSMDEKCSF CNLQREAVSD
110 120 130 140 150
CIPSLDSSQS TPTEELSSQG QSHTDKIECQ AESYLNALFR KKDLPQNCDP
160 170 180 190 200
NIPLVAQELM KKMIRQFAIE YISKSGKIQE NRNGSIGASL VCKSIQMNQA
210 220 230 240 250
DNCLQDEQEG PLDLTVTRTQ EQTAQQGDGV LDLSTKKTSI KSEESSISDP
260 270 280 290 300
SSENAVAGRL HRNREDYVER SAEFADGLLS KALKDIQSGA LDINKAGILY
310 320 330 340 350
GIPQKTLLLH LEALPAGKPA SFKNKTRDFN DSYSYNESKE TCAVLQKVAL
360 370 380 390 400
WARAQTERTE KSKLNLLETS EFKFPTASSY LHQLTLQKMV TQFKEKNESL
410 420 430 440 450
QYETSNPPVQ LKIPQLRVNS VSKSQADGSG LLDVMYQVSK TSSVLEGSAL
460 470 480 490 500
QKLKNILPKQ NKLDCSGPVT HSSVDSYFLH GDLSPLCLNS KNGTVDGTSE
510 520 530 540 550
NTEDGLDRKD NKQPRKKRGR YRQYDHEIME EAIAMVMSGK MSVSKAQGIY
560 570 580 590 600
GVPHSTLEYK VKERSGTLKT PPKKKLRLPD TGLYMTDSGT GSCRNSSKPV
Length:600
Mass (Da):66,695
Last modified:October 11, 2005 - v1
Checksum:iF87DEC6D049B51B2
GO
Isoform 2 (identifier: Q3U285-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:517
Mass (Da):57,317
Checksum:iC97403D3D296C52E
GO
Isoform 3 (identifier: Q3U285-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-315: RLHRNREDYV...TLLLHLEALP → MLQMKTDEKV...HNQNLKSEEN
     316-600: Missing.

Show »
Length:315
Mass (Da):34,829
Checksum:iC379B448E52A650C
GO
Isoform 4 (identifier: Q3U285-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-230: GDGV → ACYK
     231-600: Missing.

Show »
Length:230
Mass (Da):25,848
Checksum:i473A9C223A2DDDAD
GO
Isoform 5 (identifier: Q3U285-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: DLPQNCDPNIPLVAQELMKKMI → ADSSIWVFKRSPTNSWVSVVGY
     165-600: Missing.

Show »
Length:164
Mass (Da):18,462
Checksum:iFD764AE704780A28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 214Missing in AAH66151 (PubMed:15489334).Curated
Isoform 3 (identifier: Q3U285-3)
Sequence conflicti315 – 3151N → D in BAC31678 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_029291Add
BLAST
Alternative sequencei143 – 16422DLPQN…MKKMI → ADSSIWVFKRSPTNSWVSVV GY in isoform 5. 1 PublicationVSP_029292Add
BLAST
Alternative sequencei165 – 600436Missing in isoform 5. 1 PublicationVSP_029293Add
BLAST
Alternative sequencei227 – 2304GDGV → ACYK in isoform 4. 1 PublicationVSP_029294
Alternative sequencei231 – 600370Missing in isoform 4. 1 PublicationVSP_029295Add
BLAST
Alternative sequencei259 – 31557RLHRN…LEALP → MLQMKTDEKVDLSDGNTASC PLSPIKMCLNHPIEWNLTAA SLASCTVHNQNLKSEEN in isoform 3. 2 PublicationsVSP_029296Add
BLAST
Alternative sequencei316 – 600285Missing in isoform 3. 2 PublicationsVSP_029297Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076078 mRNA. Translation: BAC20954.1.
AK043498 mRNA. Translation: BAC31560.1.
AK043845 mRNA. Translation: BAC31678.1.
AK041987 mRNA. Translation: BAC31123.1.
AK083689 mRNA. Translation: BAC38994.1.
AK154398 mRNA. Translation: BAE32559.1.
AK155421 mRNA. Translation: BAE33257.1.
BC066151 mRNA. Translation: AAH66151.1.
BC138563 mRNA. Translation: AAI38564.1.
CCDSiCCDS19277.1. [Q3U285-3]
CCDS19278.1. [Q3U285-2]
CCDS51499.1. [Q3U285-1]
RefSeqiNP_001156545.1. NM_001163073.1. [Q3U285-1]
NP_742165.1. NM_172153.3. [Q3U285-2]
NP_835278.2. NM_178142.5. [Q3U285-3]
XP_006503888.1. XM_006503825.2. [Q3U285-6]
UniGeneiMm.71498.

Genome annotation databases

EnsembliENSMUST00000016026; ENSMUSP00000016026; ENSMUSG00000015882. [Q3U285-1]
ENSMUST00000045586; ENSMUSP00000042677; ENSMUSG00000015882. [Q3U285-3]
ENSMUST00000087164; ENSMUSP00000084408; ENSMUSG00000015882. [Q3U285-2]
GeneIDi209707.
KEGGimmu:209707.
UCSCiuc008xjh.3. mouse. [Q3U285-3]
uc008xji.3. mouse. [Q3U285-6]
uc008xjk.2. mouse. [Q3U285-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076078 mRNA. Translation: BAC20954.1.
AK043498 mRNA. Translation: BAC31560.1.
AK043845 mRNA. Translation: BAC31678.1.
AK041987 mRNA. Translation: BAC31123.1.
AK083689 mRNA. Translation: BAC38994.1.
AK154398 mRNA. Translation: BAE32559.1.
AK155421 mRNA. Translation: BAE33257.1.
BC066151 mRNA. Translation: AAH66151.1.
BC138563 mRNA. Translation: AAI38564.1.
CCDSiCCDS19277.1. [Q3U285-3]
CCDS19278.1. [Q3U285-2]
CCDS51499.1. [Q3U285-1]
RefSeqiNP_001156545.1. NM_001163073.1. [Q3U285-1]
NP_742165.1. NM_172153.3. [Q3U285-2]
NP_835278.2. NM_178142.5. [Q3U285-3]
XP_006503888.1. XM_006503825.2. [Q3U285-6]
UniGeneiMm.71498.

3D structure databases

ProteinModelPortaliQ3U285.
SMRiQ3U285. Positions 521-578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016026.

PTM databases

iPTMnetiQ3U285.
PhosphoSiteiQ3U285.

Proteomic databases

MaxQBiQ3U285.
PaxDbiQ3U285.
PRIDEiQ3U285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016026; ENSMUSP00000016026; ENSMUSG00000015882. [Q3U285-1]
ENSMUST00000045586; ENSMUSP00000042677; ENSMUSG00000015882. [Q3U285-3]
ENSMUST00000087164; ENSMUSP00000084408; ENSMUSG00000015882. [Q3U285-2]
GeneIDi209707.
KEGGimmu:209707.
UCSCiuc008xjh.3. mouse. [Q3U285-3]
uc008xji.3. mouse. [Q3U285-6]
uc008xjk.2. mouse. [Q3U285-1]

Organism-specific databases

CTDi254251.
MGIiMGI:2651932. Lcorl.

Phylogenomic databases

eggNOGiKOG4565. Eukaryota.
ENOG4111GCI. LUCA.
GeneTreeiENSGT00520000055615.
HOVERGENiHBG108084.
InParanoidiQ3U285.
OMAiYKVKERS.
OrthoDBiEOG7VHSXQ.
PhylomeDBiQ3U285.
TreeFamiTF319589.

Miscellaneous databases

ChiTaRSiLcorl. mouse.
PROiQ3U285.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U285.
ExpressionAtlasiQ3U285. baseline and differential.
GenevisibleiQ3U285. MM.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain."
    Kunieda T., Park J.-M., Takeuchi H., Kubo T.
    FEBS Lett. 535:61-65(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5).
    Strain: C57BL/6J and NOD.
    Tissue: Brain cortex and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-600 (ISOFORM 4).
    Strain: CD-1.
    Tissue: Brain and Neural stem cell.

Entry informationi

Entry nameiLCORL_MOUSE
AccessioniPrimary (citable) accession number: Q3U285
Secondary accession number(s): B2RRS7
, Q6NZG1, Q8BNH5, Q8BRN7, Q8BRT8, Q8C9J6, Q8CJG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.