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Protein

Ligand-dependent nuclear receptor corepressor-like protein

Gene

Lcorl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi543 – 563H-T-H motifPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription by RNA polymerase II Source: MGI
  • transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent nuclear receptor corepressor-like protein
Short name:
LCoR-like protein
Alternative name(s):
Mblk1-related protein 1
Transcription factor MLR1
Gene namesi
Name:Lcorl
Synonyms:Mlr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2651932 Lcorl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104641 – 600Ligand-dependent nuclear receptor corepressor-like proteinAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki318Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki396Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ3U285
PaxDbiQ3U285
PeptideAtlasiQ3U285
PRIDEiQ3U285

PTM databases

iPTMnetiQ3U285
PhosphoSitePlusiQ3U285

Expressioni

Tissue specificityi

Expressed predominantly in the spermatocytes of the testis. Also found in the kidney, liver and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000015882
ExpressionAtlasiQ3U285 baseline and differential
GenevisibleiQ3U285 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016026

Structurei

3D structure databases

ProteinModelPortaliQ3U285
SMRiQ3U285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini515 – 567HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 30Ala-richAdd BLAST22

Phylogenomic databases

eggNOGiKOG4565 Eukaryota
ENOG4111GCI LUCA
GeneTreeiENSGT00520000055615
HOVERGENiHBG108084
InParanoidiQ3U285
OMAiYKVKERS
OrthoDBiEOG091G0N6A
PhylomeDBiQ3U285
TreeFamiTF319589

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF05225 HTH_psq, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50960 HTH_PSQ, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U285-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKGRERMAA AAAAAAAAAA AQCRSPRCAA ERRGFRRELD SWRHRLMHCV
60 70 80 90 100
GFESILEGLY GPRLRRDLSL FEDCEPEELT DWSMDEKCSF CNLQREAVSD
110 120 130 140 150
CIPSLDSSQS TPTEELSSQG QSHTDKIECQ AESYLNALFR KKDLPQNCDP
160 170 180 190 200
NIPLVAQELM KKMIRQFAIE YISKSGKIQE NRNGSIGASL VCKSIQMNQA
210 220 230 240 250
DNCLQDEQEG PLDLTVTRTQ EQTAQQGDGV LDLSTKKTSI KSEESSISDP
260 270 280 290 300
SSENAVAGRL HRNREDYVER SAEFADGLLS KALKDIQSGA LDINKAGILY
310 320 330 340 350
GIPQKTLLLH LEALPAGKPA SFKNKTRDFN DSYSYNESKE TCAVLQKVAL
360 370 380 390 400
WARAQTERTE KSKLNLLETS EFKFPTASSY LHQLTLQKMV TQFKEKNESL
410 420 430 440 450
QYETSNPPVQ LKIPQLRVNS VSKSQADGSG LLDVMYQVSK TSSVLEGSAL
460 470 480 490 500
QKLKNILPKQ NKLDCSGPVT HSSVDSYFLH GDLSPLCLNS KNGTVDGTSE
510 520 530 540 550
NTEDGLDRKD NKQPRKKRGR YRQYDHEIME EAIAMVMSGK MSVSKAQGIY
560 570 580 590 600
GVPHSTLEYK VKERSGTLKT PPKKKLRLPD TGLYMTDSGT GSCRNSSKPV
Length:600
Mass (Da):66,695
Last modified:October 11, 2005 - v1
Checksum:iF87DEC6D049B51B2
GO
Isoform 2 (identifier: Q3U285-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:517
Mass (Da):57,317
Checksum:iC97403D3D296C52E
GO
Isoform 3 (identifier: Q3U285-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-315: RLHRNREDYV...TLLLHLEALP → MLQMKTDEKV...HNQNLKSEEN
     316-600: Missing.

Show »
Length:315
Mass (Da):34,829
Checksum:iC379B448E52A650C
GO
Isoform 4 (identifier: Q3U285-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-230: GDGV → ACYK
     231-600: Missing.

Show »
Length:230
Mass (Da):25,848
Checksum:i473A9C223A2DDDAD
GO
Isoform 5 (identifier: Q3U285-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-164: DLPQNCDPNIPLVAQELMKKMI → ADSSIWVFKRSPTNSWVSVVGY
     165-600: Missing.

Show »
Length:164
Mass (Da):18,462
Checksum:iFD764AE704780A28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 21Missing in AAH66151 (PubMed:15489334).Curated4
Isoform 3 (identifier: Q3U285-3)
Sequence conflicti315N → D in BAC31678 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292911 – 83Missing in isoform 2. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_029292143 – 164DLPQN…MKKMI → ADSSIWVFKRSPTNSWVSVV GY in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_029293165 – 600Missing in isoform 5. 1 PublicationAdd BLAST436
Alternative sequenceiVSP_029294227 – 230GDGV → ACYK in isoform 4. 1 Publication4
Alternative sequenceiVSP_029295231 – 600Missing in isoform 4. 1 PublicationAdd BLAST370
Alternative sequenceiVSP_029296259 – 315RLHRN…LEALP → MLQMKTDEKVDLSDGNTASC PLSPIKMCLNHPIEWNLTAA SLASCTVHNQNLKSEEN in isoform 3. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_029297316 – 600Missing in isoform 3. 2 PublicationsAdd BLAST285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076078 mRNA Translation: BAC20954.1
AK043498 mRNA Translation: BAC31560.1
AK043845 mRNA Translation: BAC31678.1
AK041987 mRNA Translation: BAC31123.1
AK083689 mRNA Translation: BAC38994.1
AK154398 mRNA Translation: BAE32559.1
AK155421 mRNA Translation: BAE33257.1
BC066151 mRNA Translation: AAH66151.1
BC138563 mRNA Translation: AAI38564.1
CCDSiCCDS19277.1 [Q3U285-3]
CCDS19278.1 [Q3U285-2]
CCDS51499.1 [Q3U285-1]
RefSeqiNP_001156545.1, NM_001163073.1 [Q3U285-1]
NP_742165.1, NM_172153.3 [Q3U285-2]
NP_835278.2, NM_178142.5 [Q3U285-3]
XP_006503888.1, XM_006503825.3 [Q3U285-6]
UniGeneiMm.71498

Genome annotation databases

EnsembliENSMUST00000016026; ENSMUSP00000016026; ENSMUSG00000015882 [Q3U285-1]
ENSMUST00000045586; ENSMUSP00000042677; ENSMUSG00000015882 [Q3U285-3]
ENSMUST00000087164; ENSMUSP00000084408; ENSMUSG00000015882 [Q3U285-2]
GeneIDi209707
KEGGimmu:209707
UCSCiuc008xjh.3 mouse [Q3U285-3]
uc008xji.3 mouse [Q3U285-6]
uc008xjk.2 mouse [Q3U285-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLCORL_MOUSE
AccessioniPrimary (citable) accession number: Q3U285
Secondary accession number(s): B2RRS7
, Q6NZG1, Q8BNH5, Q8BRN7, Q8BRT8, Q8C9J6, Q8CJG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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