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Protein

Protein SERAC1

Gene

Serac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity).By similarity

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • phospholipid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Protein family/group databases

ESTHERimouse-srac1. PGAP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SERAC1
Alternative name(s):
Serine active site-containing protein 1
Gene namesi
Name:Serac1
Synonyms:D17Ertd141e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2447813. Serac1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Protein SERAC1PRO_0000274673Add
BLAST

Proteomic databases

MaxQBiQ3U213.
PaxDbiQ3U213.
PeptideAtlasiQ3U213.
PRIDEiQ3U213.

PTM databases

PhosphoSiteiQ3U213.

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiQ3U213.
CleanExiMM_SERAC1.
GenevisibleiQ3U213. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095043.

Structurei

3D structure databases

ProteinModelPortaliQ3U213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi107 – 1104Poly-Ala
Compositional biasi194 – 1996Poly-Pro

Sequence similaritiesi

Belongs to the SERAC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2029. Eukaryota.
ENOG410YIPC. LUCA.
GeneTreeiENSGT00390000003560.
HOGENOMiHOG000154411.
HOVERGENiHBG057428.
InParanoidiQ3U213.
OMAiALVQHSK.
OrthoDBiEOG7VMP4H.
PhylomeDBiQ3U213.
TreeFamiTF319689.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U213-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRIGSFAPR SKSRTPWRNI RNIIRFTGSL IVGGSLFITY
60 70 80 90 100
EVLALKKSLM LDTQVVEREK MKSYIYVHKA PVDRLDNRGI VWQARKELHR
110 120 130 140 150
AVRKLLAAAA KVLRSPFADS FSTVDIEDHD CAVWLLLRKS REDDLAARLQ
160 170 180 190 200
AVREMSEAHH WHDYQYRIIA QACDPRTLIG LARSKESDLR FFLPPPPLPS
210 220 230 240 250
LKEDSSTEEE LRHLLASLPQ TELDECLQYF TSLALSESSQ SLAAQKGGLW
260 270 280 290 300
CFGGNGLPYA ESFGKVPSAT VEMFCLEAIV KHSEIPSHCD HIEAGGGLQL
310 320 330 340 350
LQRLYQLHKD CPKVQRNVMR IIGNMALNEH LHPAIVHSGW VSLMAEALKS
360 370 380 390 400
SHIMEASHAA RTLANLDRET VGEKYQDGVY VLHPQCRTSQ PIKADVLFIH
410 420 430 440 450
GLMGAAFKTW RQHDSQRALT ESAVVDEDRY TTCWPKTWLA KDCPSLRIIS
460 470 480 490 500
VEYDTSLSDW RARCPMERKS IAFRSNELLS KLRAAGVGDR PMIWISHSMG
510 520 530 540 550
GLLVKKMLLE ASKKPELNAL INNTRGIIFY SVPHHGSRLA EYSVNIRYLL
560 570 580 590 600
FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLNFVET QPTFIGSMIK
610 620 630 640 650
LHVVPVESAD LGIGDLIPVD VNHLNICKPK TKDAFLYQRT LQFICETLAR

DLEN
Length:654
Mass (Da):73,987
Last modified:October 11, 2005 - v1
Checksum:iD75EE0017C3B579F
GO
Isoform 2 (identifier: Q3U213-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-118: Missing.

Show »
Length:624
Mass (Da):70,648
Checksum:iDAD7409643A26AF4
GO
Isoform 3 (identifier: Q3U213-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-342: VS → DR
     343-654: Missing.

Show »
Length:342
Mass (Da):38,729
Checksum:iA095E0D0161A451D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → V in strain: C57BL/6J. 2 Publications
Natural varianti6 – 61Y → F in strain: C57BL/6J. 2 Publications
Natural varianti7 – 71C → F in strain: C57BL/6J. 2 Publications
Natural varianti25 – 251T → M.1 Publication
Natural varianti64 – 641Q → T in strain: BALB/cByJ and C57BL/6J; requires 2 nucleotide substitutions. 2 Publications
Natural varianti518 – 5181N → S.1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 11830Missing in isoform 2. 1 PublicationVSP_022864Add
BLAST
Alternative sequencei341 – 3422VS → DR in isoform 3. 1 PublicationVSP_022865
Alternative sequencei343 – 654312Missing in isoform 3. 1 PublicationVSP_022866Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019677 mRNA. Translation: BAB31833.1.
AK154605 mRNA. Translation: BAE32707.1.
AK155571 mRNA. Translation: BAE33329.1.
AK162246 mRNA. Translation: BAE36813.1.
AK170498 mRNA. Translation: BAE41837.1.
BC119594 mRNA. Translation: AAI19595.1.
BC119595 mRNA. Translation: AAI19596.1.
CCDSiCCDS28366.1. [Q3U213-2]
CCDS49933.1. [Q3U213-1]
RefSeqiNP_001104487.1. NM_001111017.1. [Q3U213-1]
NP_796285.2. NM_177311.4. [Q3U213-2]
UniGeneiMm.5548.

Genome annotation databases

EnsembliENSMUST00000024570; ENSMUSP00000024570; ENSMUSG00000015659. [Q3U213-2]
ENSMUST00000097432; ENSMUSP00000095043; ENSMUSG00000015659. [Q3U213-1]
GeneIDi321007.
KEGGimmu:321007.
UCSCiuc008afy.2. mouse. [Q3U213-2]
uc008afz.2. mouse. [Q3U213-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019677 mRNA. Translation: BAB31833.1.
AK154605 mRNA. Translation: BAE32707.1.
AK155571 mRNA. Translation: BAE33329.1.
AK162246 mRNA. Translation: BAE36813.1.
AK170498 mRNA. Translation: BAE41837.1.
BC119594 mRNA. Translation: AAI19595.1.
BC119595 mRNA. Translation: AAI19596.1.
CCDSiCCDS28366.1. [Q3U213-2]
CCDS49933.1. [Q3U213-1]
RefSeqiNP_001104487.1. NM_001111017.1. [Q3U213-1]
NP_796285.2. NM_177311.4. [Q3U213-2]
UniGeneiMm.5548.

3D structure databases

ProteinModelPortaliQ3U213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095043.

Protein family/group databases

ESTHERimouse-srac1. PGAP1.

PTM databases

PhosphoSiteiQ3U213.

Proteomic databases

MaxQBiQ3U213.
PaxDbiQ3U213.
PeptideAtlasiQ3U213.
PRIDEiQ3U213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024570; ENSMUSP00000024570; ENSMUSG00000015659. [Q3U213-2]
ENSMUST00000097432; ENSMUSP00000095043; ENSMUSG00000015659. [Q3U213-1]
GeneIDi321007.
KEGGimmu:321007.
UCSCiuc008afy.2. mouse. [Q3U213-2]
uc008afz.2. mouse. [Q3U213-1]

Organism-specific databases

CTDi84947.
MGIiMGI:2447813. Serac1.

Phylogenomic databases

eggNOGiKOG2029. Eukaryota.
ENOG410YIPC. LUCA.
GeneTreeiENSGT00390000003560.
HOGENOMiHOG000154411.
HOVERGENiHBG057428.
InParanoidiQ3U213.
OMAiALVQHSK.
OrthoDBiEOG7VMP4H.
PhylomeDBiQ3U213.
TreeFamiTF319689.

Miscellaneous databases

PROiQ3U213.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U213.
CleanExiMM_SERAC1.
GenevisibleiQ3U213. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS VAL-4; PHE-6; PHE-7 AND THR-64.
    Strain: C57BL/6J and NOD.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion."
    Schimenti J.C., Reynolds J.L., Planchart A.
    Proc. Natl. Acad. Sci. U.S.A. 102:3342-3347(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, VARIANTS VAL-4; PHE-6; PHE-7; MET-25; THR-64 AND SER-518.

Entry informationi

Entry nameiSRAC1_MOUSE
AccessioniPrimary (citable) accession number: Q3U213
Secondary accession number(s): Q3TS62, Q9D2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.