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Protein

Aryl hydrocarbon receptor repressor

Gene

Ahrr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.2 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of protein sumoylation Source: BHF-UCL
  • response to xenobiotic stimulus Source: BHF-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
  • xenobiotic metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor repressor
Short name:
AhR repressor
Short name:
AhRR
Gene namesi
Name:Ahrr
Synonyms:Kiaa1234
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333776. Ahrr.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338581 – 701Aryl hydrocarbon receptor repressorAdd BLAST701

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ3U1U7.
PaxDbiQ3U1U7.
PRIDEiQ3U1U7.

PTM databases

iPTMnetiQ3U1U7.
PhosphoSitePlusiQ3U1U7.

Expressioni

Inductioni

By 3MC. Up-regulated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and beta-naphthoflavone in pituitary.2 Publications

Gene expression databases

BgeeiENSMUSG00000021575.

Interactioni

Subunit structurei

Interacts with ARNT, ANKRA2, HDAC4 and HDAC5.2 Publications

Protein-protein interaction databases

BioGridi198038. 5 interactors.
STRINGi10090.ENSMUSP00000022059.

Structurei

3D structure databases

ProteinModelPortaliQ3U1U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 78bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini106 – 176PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni555 – 701Needed for transcriptional repressionAdd BLAST147

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
HOGENOMiHOG000033866.
HOVERGENiHBG073122.
InParanoidiQ3U1U7.
KOiK09094.
PhylomeDBiQ3U1U7.
TreeFamiTF352074.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U1U7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMIPSGECTY AGRKRRKPIQ KRRLTMGAEK SNPSKRHRDR LNTELDHLAS
60 70 80 90 100
LLPFSPDIIS KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEEH
110 120 130 140 150
SYRGFPVQEG RLLLESLNGF ALVVSAEGMI FYASATIVDY LGFHQTDVMH
160 170 180 190 200
QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF GQSPHADTDN TVLGKLLRAQ
210 220 230 240 250
EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK LKFLFGQKKK
260 270 280 290 300
TPSGTALPPR LSLFCIVAPV LPSVTEMKMK STFLKAKHRA DIVVTMDSRA
310 320 330 340 350
KAVTSLCESE LHPKLNYLAG KSNGENGISL FRGQTDRSHW ARALARSSCL
360 370 380 390 400
CLRGGPDLLD PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV
410 420 430 440 450
HLRHLNWSTE QRSQESTTKL TRQPSKNEPS TCLVPHGSCV PYPGSQGMLS
460 470 480 490 500
ASNMASFRDS LDHPTGAYCS QMNRPLSDIH QGQVDPSTCH ISQGSLGSRI
510 520 530 540 550
PLTGMQRFTA RGFSTEDAKL PSLPVTIGTP CNPVLSLDVP IKMENESGSQ
560 570 580 590 600
DIVEASTTSC LWLGTSDMAR GHLVGFPARM HLKTEPDYRQ QACTPHLGHG
610 620 630 640 650
MLGTNPYSRD TVGSCREHAP LYSAHCTCLD PEPPHHLFMC SHSESQHPSL
660 670 680 690 700
DQDCRAPIVK REPLDSPSWA APGQVTVPRM FPKSASKTVI PSKGSDGIFL

P
Length:701
Mass (Da):77,726
Last modified:October 11, 2005 - v1
Checksum:iA440A214C2AEF6E6
GO
Isoform 2 (identifier: Q3U1U7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.
Show »
Length:573
Mass (Da):63,287
Checksum:i6C1A33B26BDF3A3F
GO
Isoform 3 (identifier: Q3U1U7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-701: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):33,807
Checksum:iFD5B35AC15B09EE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3I → V in BAE32810 (PubMed:16141072).Curated1
Sequence conflicti637L → F in BAA37132 (PubMed:9887096).Curated1
Sequence conflicti637L → F in BAE32410 (PubMed:16141072).Curated1
Sequence conflicti637L → F in BAE32810 (PubMed:16141072).Curated1
Sequence conflicti637L → F in AAI18535 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0335651 – 128Missing in isoform 2. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_033566300 – 701Missing in isoform 3. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015140 mRNA. Translation: BAA37132.1.
AK154152 mRNA. Translation: BAE32410.1.
AK154761 mRNA. Translation: BAE32810.1.
AK155711 mRNA. Translation: BAE33396.1.
CT009486, AC123833 Genomic DNA. Translation: CAO77884.1.
BC118534 mRNA. Translation: AAI18535.1.
AK173134 mRNA. Translation: BAD32412.1.
CCDSiCCDS26641.1. [Q3U1U7-1]
RefSeqiNP_001304280.1. NM_001317351.1.
NP_033774.1. NM_009644.3.
XP_006517111.1. XM_006517048.1.
XP_006517112.1. XM_006517049.3.
XP_006517113.1. XM_006517050.2.
UniGeneiMm.290446.

Genome annotation databases

GeneIDi11624.
KEGGimmu:11624.
UCSCiuc007rev.1. mouse. [Q3U1U7-1]
uc007rex.1. mouse. [Q3U1U7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015140 mRNA. Translation: BAA37132.1.
AK154152 mRNA. Translation: BAE32410.1.
AK154761 mRNA. Translation: BAE32810.1.
AK155711 mRNA. Translation: BAE33396.1.
CT009486, AC123833 Genomic DNA. Translation: CAO77884.1.
BC118534 mRNA. Translation: AAI18535.1.
AK173134 mRNA. Translation: BAD32412.1.
CCDSiCCDS26641.1. [Q3U1U7-1]
RefSeqiNP_001304280.1. NM_001317351.1.
NP_033774.1. NM_009644.3.
XP_006517111.1. XM_006517048.1.
XP_006517112.1. XM_006517049.3.
XP_006517113.1. XM_006517050.2.
UniGeneiMm.290446.

3D structure databases

ProteinModelPortaliQ3U1U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198038. 5 interactors.
STRINGi10090.ENSMUSP00000022059.

PTM databases

iPTMnetiQ3U1U7.
PhosphoSitePlusiQ3U1U7.

Proteomic databases

MaxQBiQ3U1U7.
PaxDbiQ3U1U7.
PRIDEiQ3U1U7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11624.
KEGGimmu:11624.
UCSCiuc007rev.1. mouse. [Q3U1U7-1]
uc007rex.1. mouse. [Q3U1U7-3]

Organism-specific databases

CTDi57491.
MGIiMGI:1333776. Ahrr.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3560. Eukaryota.
ENOG410XRZH. LUCA.
HOGENOMiHOG000033866.
HOVERGENiHBG073122.
InParanoidiQ3U1U7.
KOiK09094.
PhylomeDBiQ3U1U7.
TreeFamiTF352074.

Miscellaneous databases

PROiQ3U1U7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021575.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAHRR_MOUSE
AccessioniPrimary (citable) accession number: Q3U1U7
Secondary accession number(s): Q147Z5
, Q3U3H6, Q69ZN4, Q9Z312
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.