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Protein
Submitted name:

Integrin alpha-M

Gene

Itgam

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha-MImported
Gene namesi
Name:ItgamImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96607. Itgam.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_500845206817 – 1232UniRule annotationAdd BLAST1216

Expressioni

Gene expression databases

BgeeiENSMUSG00000030786.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101849.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 328VWFAInterPro annotationAdd BLAST179

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
OMAiMMSEGGP.
OrthoDBiEOG091G01BZ.

Family and domain databases

CDDicd00427. Ribosomal_L29_HIP. 1 hit.
Gene3Di1.10.287.310. 1 hit.
InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR001854. Ribosomal_L29.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF46561. SSF46561. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U1U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKALLVTA LALCHGFNLD TEHPMTFQEN AKGFGQSVVQ LGGTSVVVAA
60 70 80 90 100
PQEAKAVNQT GALYQCDYST SRCHPIPLQV PPEAVNMSLG LSLAVSTVPQ
110 120 130 140 150
QLLACGPTVH QNCKENTYVN GLCYLFGSNL LRPPQQFPEA LRECPQQESD
160 170 180 190 200
IVFLIDGSGS INNIDFQKMK EFVSTVMEQF KKSKTLFSLM QYSDEFRIHF
210 220 230 240 250
TFNDFKRNPS PRSHVSPIKQ LNGRTKTASG IRKVVRELFH KTNGARENAA
260 270 280 290 300
KILVVITDGE KFGDPLDYKD VIPEADRAGV IRYVIGVGNA FNKPQSRREL
310 320 330 340 350
DTIASKPAGE HVFQVDNFEA LNTIQNQLQE KIFAIEGTQT GSTSSFEHEM
360 370 380 390 400
SQEGFSASIT SNGPLLGSVG SFDWAGGAFL YTSKDKVTFI NTTRVDSDMN
410 420 430 440 450
DAYLGYASAV ILRNRVQSLV LGAPRYQHIG LVVMFRENFG TWEPHTSIKG
460 470 480 490 500
SQIGSYFGAS LCSVDMDADG NTNLILIGAP HYYEKTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCEALLH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI GAPGEQENQG
560 570 580 590 600
AVYIFYGASI ASLSASHSQR IIGAHFSPGL QYFGQSLSGG KDLTMDGLMD
610 620 630 640 650
LAVGAQGHLL LLRAQPVLRL EATMEFSPKK VARSVFACQE QVLKNKDAGE
660 670 680 690 700
VRVCLRVRKN TKDRLREGDI QSTVTYDLAL DPGRSRIRAF FDETKNNTRR
710 720 730 740 750
RTQVFGLMQK CETLKLILPD CVDDSVSPII LRLNYTLVGE PLRSFGNLRP
760 770 780 790 800
VLAMDAQRFF TAMFPFEKNC GNDSICQDDL SITMSAMGLD TLVVGGPQDF
810 820 830 840 850
NMSVTLRNDG EDSYGTQVTV YYPSGLSYRK DSASQNPLTK KPWFVKPAES
860 870 880 890 900
SSSSEGHGAL KSTTWNINHP IFPANSEVTF NVTFDVDSHA SFGNKLLLKA
910 920 930 940 950
IVASENNMSR THKTKFQLEL PVKYAIYMIV TSDESSIRYL NFTASEMTSK
960 970 980 990 1000
VIQHQYQFNN LGQRSLPVSV VFWIPVQINN VTVWDHPQVI FSQNLSSACH
1010 1020 1030 1040 1050
TEQKSPPHSN FRDQLERTPV LNCSVAVCKR IQCDLPSFNT QEIFNVTLKG
1060 1070 1080 1090 1100
NLSFDWYIKT SHGHLLLVSS TEILFNDSAF ALLPGQESYV RSKTETKVEP
1110 1120 1130 1140 1150
YEVHNPVPLI VGSSIGGLVL LALITAGLYK AASAVNNAEM VKIKARDLHD
1160 1170 1180 1190 1200
KKKEELLKQL DDLKVELSQL PVAKVTGSAA SKLSNPKSSL LLTRLKKKTS
1210 1220 1230
GNSTRARSTS PWACDPRRLE PCVTRSPNTR RS
Length:1,232
Mass (Da):135,945
Last modified:October 11, 2005 - v1
Checksum:iC4C0B3E15AD7B55A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093175 Genomic DNA. No translation available.
AC124566 Genomic DNA. No translation available.
AK155717 mRNA. Translation: BAE33399.1.
UniGeneiMm.262106.

Genome annotation databases

EnsembliENSMUST00000098015; ENSMUSP00000095625; ENSMUSG00000108596.
UCSCiuc009jya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093175 Genomic DNA. No translation available.
AC124566 Genomic DNA. No translation available.
AK155717 mRNA. Translation: BAE33399.1.
UniGeneiMm.262106.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098015; ENSMUSP00000095625; ENSMUSG00000108596.
UCSCiuc009jya.1. mouse.

Organism-specific databases

CTDi3684.
MGIiMGI:96607. Itgam.

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
OMAiMMSEGGP.
OrthoDBiEOG091G01BZ.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiItgam. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030786.

Family and domain databases

CDDicd00427. Ribosomal_L29_HIP. 1 hit.
Gene3Di1.10.287.310. 1 hit.
InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR032695. Integrin_dom.
IPR001854. Ribosomal_L29.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF46561. SSF46561. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U1U4_MOUSE
AccessioniPrimary (citable) accession number: Q3U1U4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.