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Protein
Submitted name:

Integrin alpha-M

Gene

Itgam

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-166016 Toll Like Receptor 4 (TLR4) Cascade
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-216083 Integrin cell surface interactions
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha-MImported
Gene namesi
Name:ItgamImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96607 Itgam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_501448667717 – 1232UniRule annotationAdd BLAST1216

Expressioni

Gene expression databases

BgeeiENSMUSG00000108596

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 75FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati76 – 135FG-GAPPROSITE-ProRule annotationAdd BLAST60
Domaini150 – 328VWFAInterPro annotationAdd BLAST179
Repeati339 – 390FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati391 – 442FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati443 – 503FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati506 – 564FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati569 – 629FG-GAPPROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1146 – 1166Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000113114
HOVERGENiHBG100530
OMAiVTSENNM
OrthoDBiEOG091G01BZ

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR036049 Ribosomal_L29/L35_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF46561 SSF46561, 1 hit
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3U1U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKALLVTA LALCHGFNLD TEHPMTFQEN AKGFGQSVVQ LGGTSVVVAA
60 70 80 90 100
PQEAKAVNQT GALYQCDYST SRCHPIPLQV PPEAVNMSLG LSLAVSTVPQ
110 120 130 140 150
QLLACGPTVH QNCKENTYVN GLCYLFGSNL LRPPQQFPEA LRECPQQESD
160 170 180 190 200
IVFLIDGSGS INNIDFQKMK EFVSTVMEQF KKSKTLFSLM QYSDEFRIHF
210 220 230 240 250
TFNDFKRNPS PRSHVSPIKQ LNGRTKTASG IRKVVRELFH KTNGARENAA
260 270 280 290 300
KILVVITDGE KFGDPLDYKD VIPEADRAGV IRYVIGVGNA FNKPQSRREL
310 320 330 340 350
DTIASKPAGE HVFQVDNFEA LNTIQNQLQE KIFAIEGTQT GSTSSFEHEM
360 370 380 390 400
SQEGFSASIT SNGPLLGSVG SFDWAGGAFL YTSKDKVTFI NTTRVDSDMN
410 420 430 440 450
DAYLGYASAV ILRNRVQSLV LGAPRYQHIG LVVMFRENFG TWEPHTSIKG
460 470 480 490 500
SQIGSYFGAS LCSVDMDADG NTNLILIGAP HYYEKTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCEALLH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI GAPGEQENQG
560 570 580 590 600
AVYIFYGASI ASLSASHSQR IIGAHFSPGL QYFGQSLSGG KDLTMDGLMD
610 620 630 640 650
LAVGAQGHLL LLRAQPVLRL EATMEFSPKK VARSVFACQE QVLKNKDAGE
660 670 680 690 700
VRVCLRVRKN TKDRLREGDI QSTVTYDLAL DPGRSRIRAF FDETKNNTRR
710 720 730 740 750
RTQVFGLMQK CETLKLILPD CVDDSVSPII LRLNYTLVGE PLRSFGNLRP
760 770 780 790 800
VLAMDAQRFF TAMFPFEKNC GNDSICQDDL SITMSAMGLD TLVVGGPQDF
810 820 830 840 850
NMSVTLRNDG EDSYGTQVTV YYPSGLSYRK DSASQNPLTK KPWFVKPAES
860 870 880 890 900
SSSSEGHGAL KSTTWNINHP IFPANSEVTF NVTFDVDSHA SFGNKLLLKA
910 920 930 940 950
IVASENNMSR THKTKFQLEL PVKYAIYMIV TSDESSIRYL NFTASEMTSK
960 970 980 990 1000
VIQHQYQFNN LGQRSLPVSV VFWIPVQINN VTVWDHPQVI FSQNLSSACH
1010 1020 1030 1040 1050
TEQKSPPHSN FRDQLERTPV LNCSVAVCKR IQCDLPSFNT QEIFNVTLKG
1060 1070 1080 1090 1100
NLSFDWYIKT SHGHLLLVSS TEILFNDSAF ALLPGQESYV RSKTETKVEP
1110 1120 1130 1140 1150
YEVHNPVPLI VGSSIGGLVL LALITAGLYK AASAVNNAEM VKIKARDLHD
1160 1170 1180 1190 1200
KKKEELLKQL DDLKVELSQL PVAKVTGSAA SKLSNPKSSL LLTRLKKKTS
1210 1220 1230
GNSTRARSTS PWACDPRRLE PCVTRSPNTR RS
Length:1,232
Mass (Da):135,945
Last modified:October 11, 2005 - v1
Checksum:iC4C0B3E15AD7B55A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093175 Genomic DNA No translation available.
AC124566 Genomic DNA No translation available.
AK155717 mRNA Translation: BAE33399.1
UniGeneiMm.262106

Genome annotation databases

EnsembliENSMUST00000098015; ENSMUSP00000095625; ENSMUSG00000108596
UCSCiuc009jya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3U1U4_MOUSE
AccessioniPrimary (citable) accession number: Q3U1U4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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