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Protein
Submitted name:

Putative uncharacterized protein

Gene

Rora

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cellular response to hypoxia Source: MGI
  • cellular response to interleukin-1 Source: MGI
  • cellular response to sterol Source: MGI
  • cellular response to tumor necrosis factor Source: MGI
  • cerebellar Purkinje cell differentiation Source: MGI
  • cGMP metabolic process Source: MGI
  • intracellular receptor signaling pathway Source: MGI
  • muscle cell differentiation Source: MGI
  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • nitric oxide biosynthetic process Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of vascular endothelial growth factor production Source: MGI
  • regulation of macrophage activation Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • triglyceride homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:RoraImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104661. Rora.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034766.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106848.
KOiK08532.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFVIAAMKA QIEIIPCKIC GDKSSGIHYG VITCEGCKGF FRRSQQSNAT
60 70 80 90 100
YSCPRQKNCL IDRTSRNRCQ HCRLQKCLAV GMSRDAVKFG RMSKKQRDSL
110 120 130 140 150
YAEVQKHRMQ QQQRDHQQQP GEAEPLTPTY NISANGLTEL HDDLSTYMDG
160 170 180 190 200
HTPEGSKADS AVSSFYLDIQ PSPDQSGLDI NGIKPEPICD YTPASGFFPY
210 220 230 240 250
CSFTNGETSP TVSMAELEHL AQNISKSHLE TCQYLREELQ QITWQTFLQE
260 270 280 290 300
EIENYQNKQR EVMWQLCAIK ITEAIQYVVE FAKRIDGFME LCQNDQIVLL
310 320 330 340 350
KAGSLEVVFI RMCRAFDSQN NTVYFDGKYA SPDVFKSLGC EDFISFVFEF
360 370 380 390 400
GKSLCSMHLT EDEIALFSAF VLMSADRSWL QEKVKIEKLQ QKIQLALQHV
410 420 430 440 450
LQKNHREDGI LTKLICKVST LRALCGRHTE KLMAFKAIYP DIVRLHFPPL
460
YKELFTSEFE PAMQIDG
Length:467
Mass (Da):53,414
Last modified:October 11, 2005 - v1
Checksum:i5621E275EC282A54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149294 mRNA. Translation: BAE28797.1.
AK155827 mRNA. Translation: BAE33451.1.
RefSeqiNP_001276845.1. NM_001289916.1.
UniGeneiMm.378450.
Mm.391890.
Mm.427266.
Mm.445802.
Mm.491288.

Genome annotation databases

GeneIDi19883.
KEGGimmu:19883.
UCSCiuc009qna.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149294 mRNA. Translation: BAE28797.1.
AK155827 mRNA. Translation: BAE33451.1.
RefSeqiNP_001276845.1. NM_001289916.1.
UniGeneiMm.378450.
Mm.391890.
Mm.427266.
Mm.445802.
Mm.491288.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19883.
KEGGimmu:19883.
UCSCiuc009qna.1. mouse.

Organism-specific databases

CTDi6095.
MGIiMGI:104661. Rora.

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106848.
KOiK08532.

Miscellaneous databases

ChiTaRSiRora. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: RetinaImported.

Entry informationi

Entry nameiQ3U1P4_MOUSE
AccessioniPrimary (citable) accession number: Q3U1P4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.