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Q3U1N2

- SRBP2_MOUSE

UniProt

Q3U1N2 - SRBP2_MOUSE

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Protein

Sterol regulatory element-binding protein 2

Gene

Srebf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei457 – 4582Cleavage; by caspase-3 and caspase-7By similarity
Sitei473 – 4742Cleavage; by S2PBy similarity
Sitei511 – 5122Cleavage; by S1PBy similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. E-box binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB-KW
  2. negative regulation of cholesterol efflux Source: Ensembl
  3. positive regulation of cholesterol storage Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. regulation of cholesterol homeostasis Source: MGI
  6. regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. regulation of transcription, DNA-templated Source: MGI
  8. response to low-density lipoprotein particle Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_198969. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol regulatory element-binding protein 2
Short name:
SREBP-2
Alternative name(s):
Sterol regulatory element-binding transcription factor 2
Cleaved into the following chain:
Gene namesi
Name:Srebf2Imported
Synonyms:Srebp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:107585. Srebf2.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicleCOPII-coated vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.By similarity
Chain Processed sterol regulatory element-binding protein 2 : Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. Golgi apparatus Source: UniProtKB-KW
  4. membrane Source: BHF-UCL
  5. nucleolus Source: Ensembl
  6. nucleoplasm Source: Reactome
  7. nucleus Source: BHF-UCL
  8. SREBP-SCAP-Insig complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death around embryonic day 7-8.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11301130Sterol regulatory element-binding protein 2PRO_0000317059Add
BLAST
Chaini1 – 473473Processed sterol regulatory element-binding protein 2By similarityPRO_0000317060Add
BLAST

Post-translational modificationi

At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7 (By similarity).By similarity
Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3U1N2.
PRIDEiQ3U1N2.

PTM databases

PhosphoSiteiQ3U1N2.

Expressioni

Gene expression databases

BgeeiQ3U1N2.
CleanExiMM_SREBF2.
GenevestigatoriQ3U1N2.

Interactioni

Subunit structurei

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein (By similarity). Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminal domain) with RNF139 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SrfQ9JM733EBI-645275,EBI-493266

Protein-protein interaction databases

BioGridi203496. 3 interactions.
IntActiQ3U1N2. 1 interaction.
MINTiMINT-1739369.

Structurei

3D structure databases

ProteinModelPortaliQ3U1N2.
SMRiQ3U1N2. Positions 332-392.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 470470CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini492 – 52231LumenalSequence AnalysisAdd
BLAST
Topological domaini544 – 1130587CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei471 – 49121HelicalSequence AnalysisAdd
BLAST
Transmembranei523 – 54321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini319 – 36951bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050Transcriptional activation (acidic)Sequence AnalysisAdd
BLAST
Regioni226 – 480255Interaction with LMNABy similarityAdd
BLAST
Regioni369 – 39022Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 13137Pro-richSequence AnalysisAdd
BLAST
Compositional biasi114 – 233120Gln-richSequence AnalysisAdd
BLAST
Compositional biasi121 – 235115Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242942.
GeneTreeiENSGT00390000017651.
HOGENOMiHOG000007091.
HOVERGENiHBG061592.
InParanoidiQ3U1N2.
KOiK09107.
OMAiDVICRWW.
OrthoDBiEOG7D85VS.
PhylomeDBiQ3U1N2.
TreeFamiTF313894.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003006. Ig/MHC_CS.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q3U1N2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDESSELGVL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL
60 70 80 90 100
CSSFPGGGSN GGSGNNSSGR GNNGGATDPA VQRSFSQVPL STFSPSAASP
110 120 130 140 150
QAPALQVKVS PTPPRATPVL QPRPQPQPQP PAQLQQQTVM ITPTFSTAPQ
160 170 180 190 200
TRIIQQPLIY QNAATSFQVL QPQVQSLVTS PQVQPVTIQQ QVQTVQAQRV
210 220 230 240 250
LTQTANGTLQ TLAPATVQTV AAPQVQQVPV LVQPQIIKTD SLVLTTLKTD
260 270 280 290 300
GSPVMAAVQN PALTALTAPI QTAALQVPTL VGSNGTILTT MPVMMGQEKV
310 320 330 340 350
PIKQVPGGVK QLDPPKEGER RTTHNIIEKR YRSSINDKII ELKDLVMGTD
360 370 380 390 400
AKMHKSGVLR KAIDYIKYLQ QVNHKLRQEN MVLKLANQKN KLLKGIDLGS
410 420 430 440 450
LVDSDVDLKI DDFNQNVLLM SPPASDSGSQ AGFSPYSIDS EPGSPLLDDA
460 470 480 490 500
KVKDEPDSPP VALGMVDRSR ILLCVLTFLG LSFNPLTSLL QWGGAHNTDQ
510 520 530 540 550
HPYSGSGRSV LSLESGAGGW FDWMVPTLLL WLVNGVIVLS VFVKLLVHGE
560 570 580 590 600
PVIRPHSRPS VTFWRHRKQA DLDLAKGDFA AAAANLQTCL SVLGRALPTS
610 620 630 640 650
RLDLACSLSW NVIRYSLQKL RLVRWLLKKV FQRWRATPAT AAGFEDEAKS
660 670 680 690 700
SARDAALAYH RLHQLHITGK LPAGSACSDV HMALCAVNLA ECAEEKILPS
710 720 730 740 750
TLIEIHLTAA MGLKTRCGGK LGFLASYFLN RAQSLCGPEH STVPDSLRWL
760 770 780 790 800
CHPLGQKFFM ERSWSIKSAA KESLYCAQRS PADPIAQVHQ AFCKNLLERA
810 820 830 840 850
VESLVKPQAK KKAGDQEEES CEFSSALEYL KLLHSFVDSV GFVTSPFSSS
860 870 880 890 900
SVLRSALGPD VICRWWTSAV TMAISWLQGD DAAVRSRFTE VERVPKALEV
910 920 930 940 950
TESPLVKAVF YTCRAMHASL SGKADGQQNS FCHCERASGH LWSSLNVSGT
960 970 980 990 1000
TSDPSLNHVI QLFTCDLLLS LRTALWQKQA SASQLLGETY HASGTELAGF
1010 1020 1030 1040 1050
QRDLGSLRRL AHSFRPAYRK VFLHEATVRL MAGASPTRTH QLLEHSLRRR
1060 1070 1080 1090 1100
PTQNTKHGEV DTWPGQRERA TAILLACRHL PLSFLSSPGQ RAVLLAEAAR
1110 1120 1130
TLEKVGDRRS CSDCQQMIVK LGGGTAIAAS
Length:1,130
Mass (Da):122,911
Last modified:February 5, 2008 - v2
Checksum:i052E858B0C3945F2
GO
Isoform 21 Publication (identifier: Q3U1N2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-96: Missing.
     1105-1130: VGDRRSCSDCQQMIVKLGGGTAIAAS → SCEDEGKTDCSELLPAKAFGSFRASRTMGRAP

Note: No experimental confirmation available.Curated

Show »
Length:1,096
Mass (Da):119,913
Checksum:iBCAF1B3BC6845F5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti334 – 3341S → F in AAK54763. (PubMed:11929849)Curated
Sequence conflicti621 – 6211R → H in AAK54763. (PubMed:11929849)Curated
Sequence conflicti698 – 6981L → P in AAK54763. (PubMed:11929849)Curated
Sequence conflicti899 – 8991E → K in AAK54763. (PubMed:11929849)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 9640Missing in isoform 2. 1 PublicationVSP_052658Add
BLAST
Alternative sequencei1105 – 113026VGDRR…AIAAS → SCEDEGKTDCSELLPAKAFG SFRASRTMGRAP in isoform 2. 1 PublicationVSP_052659Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK155857 mRNA. Translation: BAE33463.1.
AC105358 Genomic DNA. No translation available.
AF374267 mRNA. Translation: AAK54763.1.
AF289715 mRNA. Translation: AAG01859.2.
CCDSiCCDS27683.1. [Q3U1N2-1]
RefSeqiNP_150087.1. NM_033218.1. [Q3U1N2-1]
UniGeneiMm.38016.

Genome annotation databases

EnsembliENSMUST00000023100; ENSMUSP00000023100; ENSMUSG00000022463. [Q3U1N2-1]
GeneIDi20788.
KEGGimmu:20788.
UCSCiuc007wyi.1. mouse. [Q3U1N2-1]
uc011zwr.1. mouse. [Q3U1N2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK155857 mRNA. Translation: BAE33463.1 .
AC105358 Genomic DNA. No translation available.
AF374267 mRNA. Translation: AAK54763.1 .
AF289715 mRNA. Translation: AAG01859.2 .
CCDSi CCDS27683.1. [Q3U1N2-1 ]
RefSeqi NP_150087.1. NM_033218.1. [Q3U1N2-1 ]
UniGenei Mm.38016.

3D structure databases

ProteinModelPortali Q3U1N2.
SMRi Q3U1N2. Positions 332-392.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203496. 3 interactions.
IntActi Q3U1N2. 1 interaction.
MINTi MINT-1739369.

PTM databases

PhosphoSitei Q3U1N2.

Proteomic databases

MaxQBi Q3U1N2.
PRIDEi Q3U1N2.

Protocols and materials databases

DNASUi 20788.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023100 ; ENSMUSP00000023100 ; ENSMUSG00000022463 . [Q3U1N2-1 ]
GeneIDi 20788.
KEGGi mmu:20788.
UCSCi uc007wyi.1. mouse. [Q3U1N2-1 ]
uc011zwr.1. mouse. [Q3U1N2-2 ]

Organism-specific databases

CTDi 6721.
MGIi MGI:107585. Srebf2.

Phylogenomic databases

eggNOGi NOG242942.
GeneTreei ENSGT00390000017651.
HOGENOMi HOG000007091.
HOVERGENi HBG061592.
InParanoidi Q3U1N2.
KOi K09107.
OMAi DVICRWW.
OrthoDBi EOG7D85VS.
PhylomeDBi Q3U1N2.
TreeFami TF313894.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
REACT_198969. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

ChiTaRSi SREBF2. mouse.
NextBioi 299519.
PROi Q3U1N2.
SOURCEi Search...

Gene expression databases

Bgeei Q3U1N2.
CleanExi MM_SREBF2.
Genevestigatori Q3U1N2.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR003006. Ig/MHC_CS.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6JImported.
    Tissue: Dendritic cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies."
    Lloyd D.J., Trembath R.C., Shackleton S.
    Hum. Mol. Genet. 11:769-777(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1096 (ISOFORM 1), INTERACTION WITH LMNA.
    Strain: Swiss albino1 Publication.
    Tissue: Adipocyte1 Publication.
  4. "Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination."
    Salles J., Sargueil F., Knoll-Gellida A., Witters L.A., Cassagne C., Garbay B.
    Biochim. Biophys. Acta 1631:229-238(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-392.
  5. "Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2."
    Horton J.D., Shimomura I., Brown M.S., Hammer R.E., Goldstein J.L., Shimano H.
    J. Clin. Invest. 101:2331-2339(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver."
    Horton J.D., Goldstein J.L., Brown M.S.
    J. Clin. Invest. 109:1125-1131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, DISRUPTION PHENOTYPE.
  7. "AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice."
    Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., Gao B., Wierzbicki M., Verbeuren T.J., Shaw R.J., Cohen R.A., Zang M.
    Cell Metab. 13:376-388(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY AMPK.

Entry informationi

Entry nameiSRBP2_MOUSE
AccessioniPrimary (citable) accession number: Q3U1N2
Secondary accession number(s): Q925C2, Q9ESZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice overexpressing processed Srebf2 show preferential activation of cholesterol over fatty acid synthesis in liver and adipose tissue.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3