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Q3U1N2

- SRBP2_MOUSE

UniProt

Q3U1N2 - SRBP2_MOUSE

Protein

Sterol regulatory element-binding protein 2

Gene

Srebf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei457 – 4582Cleavage; by caspase-3 and caspase-7By similarity
    Sitei473 – 4742Cleavage; by S2PBy similarity
    Sitei511 – 5122Cleavage; by S1PBy similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. E-box binding Source: Ensembl
    3. protein binding Source: IntAct
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: MGI
    6. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. cholesterol metabolic process Source: UniProtKB-KW
    2. negative regulation of cholesterol efflux Source: Ensembl
    3. positive regulation of cholesterol storage Source: Ensembl
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. regulation of cholesterol homeostasis Source: MGI
    6. regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. regulation of transcription, DNA-templated Source: MGI
    8. response to low-density lipoprotein particle Source: Ensembl
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.
    REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_198969. Activation of gene expression by SREBF (SREBP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol regulatory element-binding protein 2
    Short name:
    SREBP-2
    Alternative name(s):
    Sterol regulatory element-binding transcription factor 2
    Cleaved into the following chain:
    Gene namesi
    Name:Srebf2Imported
    Synonyms:Srebp2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:107585. Srebf2.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasmic vesicleCOPII-coated vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.By similarity
    Chain Processed sterol regulatory element-binding protein 2 : Nucleus By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. ER to Golgi transport vesicle membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB-SubCell
    4. membrane Source: BHF-UCL
    5. nucleoplasm Source: Reactome
    6. nucleus Source: BHF-UCL
    7. SREBP-SCAP-Insig complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Death around embryonic day 7-8.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11301130Sterol regulatory element-binding protein 2PRO_0000317059Add
    BLAST
    Chaini1 – 473473Processed sterol regulatory element-binding protein 2By similarityPRO_0000317060Add
    BLAST

    Post-translational modificationi

    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7 By similarity.By similarity
    Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3U1N2.

    PTM databases

    PhosphoSiteiQ3U1N2.

    Expressioni

    Gene expression databases

    BgeeiQ3U1N2.
    CleanExiMM_SREBF2.
    GenevestigatoriQ3U1N2.

    Interactioni

    Subunit structurei

    Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein By similarity. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminal domain) with RNF139 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SrfQ9JM733EBI-645275,EBI-493266

    Protein-protein interaction databases

    BioGridi203496. 3 interactions.
    IntActiQ3U1N2. 1 interaction.
    MINTiMINT-1739369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3U1N2.
    SMRiQ3U1N2. Positions 332-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 470470CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini492 – 52231LumenalSequence AnalysisAdd
    BLAST
    Topological domaini544 – 1130587CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei471 – 49121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini319 – 36951bHLHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5050Transcriptional activation (acidic)Sequence AnalysisAdd
    BLAST
    Regioni226 – 480255Interaction with LMNABy similarityAdd
    BLAST
    Regioni369 – 39022Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 13137Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi114 – 233120Gln-richSequence AnalysisAdd
    BLAST
    Compositional biasi121 – 235115Gln-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242942.
    GeneTreeiENSGT00390000017651.
    HOGENOMiHOG000007091.
    HOVERGENiHBG061592.
    InParanoidiQ3U1N2.
    KOiK09107.
    OMAiDVICRWW.
    OrthoDBiEOG7D85VS.
    PhylomeDBiQ3U1N2.
    TreeFamiTF313894.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003006. Ig/MHC_CS.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q3U1N2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDESSELGVL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL     50
    CSSFPGGGSN GGSGNNSSGR GNNGGATDPA VQRSFSQVPL STFSPSAASP 100
    QAPALQVKVS PTPPRATPVL QPRPQPQPQP PAQLQQQTVM ITPTFSTAPQ 150
    TRIIQQPLIY QNAATSFQVL QPQVQSLVTS PQVQPVTIQQ QVQTVQAQRV 200
    LTQTANGTLQ TLAPATVQTV AAPQVQQVPV LVQPQIIKTD SLVLTTLKTD 250
    GSPVMAAVQN PALTALTAPI QTAALQVPTL VGSNGTILTT MPVMMGQEKV 300
    PIKQVPGGVK QLDPPKEGER RTTHNIIEKR YRSSINDKII ELKDLVMGTD 350
    AKMHKSGVLR KAIDYIKYLQ QVNHKLRQEN MVLKLANQKN KLLKGIDLGS 400
    LVDSDVDLKI DDFNQNVLLM SPPASDSGSQ AGFSPYSIDS EPGSPLLDDA 450
    KVKDEPDSPP VALGMVDRSR ILLCVLTFLG LSFNPLTSLL QWGGAHNTDQ 500
    HPYSGSGRSV LSLESGAGGW FDWMVPTLLL WLVNGVIVLS VFVKLLVHGE 550
    PVIRPHSRPS VTFWRHRKQA DLDLAKGDFA AAAANLQTCL SVLGRALPTS 600
    RLDLACSLSW NVIRYSLQKL RLVRWLLKKV FQRWRATPAT AAGFEDEAKS 650
    SARDAALAYH RLHQLHITGK LPAGSACSDV HMALCAVNLA ECAEEKILPS 700
    TLIEIHLTAA MGLKTRCGGK LGFLASYFLN RAQSLCGPEH STVPDSLRWL 750
    CHPLGQKFFM ERSWSIKSAA KESLYCAQRS PADPIAQVHQ AFCKNLLERA 800
    VESLVKPQAK KKAGDQEEES CEFSSALEYL KLLHSFVDSV GFVTSPFSSS 850
    SVLRSALGPD VICRWWTSAV TMAISWLQGD DAAVRSRFTE VERVPKALEV 900
    TESPLVKAVF YTCRAMHASL SGKADGQQNS FCHCERASGH LWSSLNVSGT 950
    TSDPSLNHVI QLFTCDLLLS LRTALWQKQA SASQLLGETY HASGTELAGF 1000
    QRDLGSLRRL AHSFRPAYRK VFLHEATVRL MAGASPTRTH QLLEHSLRRR 1050
    PTQNTKHGEV DTWPGQRERA TAILLACRHL PLSFLSSPGQ RAVLLAEAAR 1100
    TLEKVGDRRS CSDCQQMIVK LGGGTAIAAS 1130
    Length:1,130
    Mass (Da):122,911
    Last modified:February 5, 2008 - v2
    Checksum:i052E858B0C3945F2
    GO
    Isoform 21 Publication (identifier: Q3U1N2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-96: Missing.
         1105-1130: VGDRRSCSDCQQMIVKLGGGTAIAAS → SCEDEGKTDCSELLPAKAFGSFRASRTMGRAP

    Note: No experimental confirmation available.Curated

    Show »
    Length:1,096
    Mass (Da):119,913
    Checksum:iBCAF1B3BC6845F5B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti334 – 3341S → F in AAK54763. (PubMed:11929849)Curated
    Sequence conflicti621 – 6211R → H in AAK54763. (PubMed:11929849)Curated
    Sequence conflicti698 – 6981L → P in AAK54763. (PubMed:11929849)Curated
    Sequence conflicti899 – 8991E → K in AAK54763. (PubMed:11929849)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei57 – 9640Missing in isoform 2. 1 PublicationVSP_052658Add
    BLAST
    Alternative sequencei1105 – 113026VGDRR…AIAAS → SCEDEGKTDCSELLPAKAFG SFRASRTMGRAP in isoform 2. 1 PublicationVSP_052659Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155857 mRNA. Translation: BAE33463.1.
    AC105358 Genomic DNA. No translation available.
    AF374267 mRNA. Translation: AAK54763.1.
    AF289715 mRNA. Translation: AAG01859.2.
    CCDSiCCDS27683.1. [Q3U1N2-1]
    RefSeqiNP_150087.1. NM_033218.1. [Q3U1N2-1]
    UniGeneiMm.38016.

    Genome annotation databases

    EnsembliENSMUST00000023100; ENSMUSP00000023100; ENSMUSG00000022463. [Q3U1N2-1]
    GeneIDi20788.
    KEGGimmu:20788.
    UCSCiuc007wyi.1. mouse. [Q3U1N2-1]
    uc011zwr.1. mouse. [Q3U1N2-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK155857 mRNA. Translation: BAE33463.1 .
    AC105358 Genomic DNA. No translation available.
    AF374267 mRNA. Translation: AAK54763.1 .
    AF289715 mRNA. Translation: AAG01859.2 .
    CCDSi CCDS27683.1. [Q3U1N2-1 ]
    RefSeqi NP_150087.1. NM_033218.1. [Q3U1N2-1 ]
    UniGenei Mm.38016.

    3D structure databases

    ProteinModelPortali Q3U1N2.
    SMRi Q3U1N2. Positions 332-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203496. 3 interactions.
    IntActi Q3U1N2. 1 interaction.
    MINTi MINT-1739369.

    PTM databases

    PhosphoSitei Q3U1N2.

    Proteomic databases

    PRIDEi Q3U1N2.

    Protocols and materials databases

    DNASUi 20788.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023100 ; ENSMUSP00000023100 ; ENSMUSG00000022463 . [Q3U1N2-1 ]
    GeneIDi 20788.
    KEGGi mmu:20788.
    UCSCi uc007wyi.1. mouse. [Q3U1N2-1 ]
    uc011zwr.1. mouse. [Q3U1N2-2 ]

    Organism-specific databases

    CTDi 6721.
    MGIi MGI:107585. Srebf2.

    Phylogenomic databases

    eggNOGi NOG242942.
    GeneTreei ENSGT00390000017651.
    HOGENOMi HOG000007091.
    HOVERGENi HBG061592.
    InParanoidi Q3U1N2.
    KOi K09107.
    OMAi DVICRWW.
    OrthoDBi EOG7D85VS.
    PhylomeDBi Q3U1N2.
    TreeFami TF313894.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.
    REACT_198968. Regulation of cholesterol biosynthesis by SREBP (SREBF).
    REACT_198969. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    ChiTaRSi SREBF2. mouse.
    NextBioi 299519.
    PROi Q3U1N2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3U1N2.
    CleanExi MM_SREBF2.
    Genevestigatori Q3U1N2.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003006. Ig/MHC_CS.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6JImported.
      Tissue: Dendritic cell.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies."
      Lloyd D.J., Trembath R.C., Shackleton S.
      Hum. Mol. Genet. 11:769-777(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1096 (ISOFORM 1), INTERACTION WITH LMNA.
      Strain: Swiss albino1 Publication.
      Tissue: Adipocyte1 Publication.
    4. "Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination."
      Salles J., Sargueil F., Knoll-Gellida A., Witters L.A., Cassagne C., Garbay B.
      Biochim. Biophys. Acta 1631:229-238(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-392.
    5. "Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2."
      Horton J.D., Shimomura I., Brown M.S., Hammer R.E., Goldstein J.L., Shimano H.
      J. Clin. Invest. 101:2331-2339(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver."
      Horton J.D., Goldstein J.L., Brown M.S.
      J. Clin. Invest. 109:1125-1131(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, DISRUPTION PHENOTYPE.
    7. "AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice."
      Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., Gao B., Wierzbicki M., Verbeuren T.J., Shaw R.J., Cohen R.A., Zang M.
      Cell Metab. 13:376-388(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY AMPK.

    Entry informationi

    Entry nameiSRBP2_MOUSE
    AccessioniPrimary (citable) accession number: Q3U1N2
    Secondary accession number(s): Q925C2, Q9ESZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mice overexpressing processed Srebf2 show preferential activation of cholesterol over fatty acid synthesis in liver and adipose tissue.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3