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Protein
Submitted name:

A disintegrin and metallopeptidase domain 8, isoform CRA_c

Gene

Adam8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi329Zinc; catalyticPROSITE-ProRule annotation1
Active sitei330PROSITE-ProRule annotation1
Metal bindingi333Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi339Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinImported
LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin and metallopeptidase domain 8, isoform CRA_cImported
Gene namesi
Name:Adam8Imported
ORF Names:mCG_21624Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107825. Adam8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei659 – 683HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501084335417 – 826Sequence analysisAdd BLAST810

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi461 ↔ 481PROSITE-ProRule annotation
Disulfide bondi615 ↔ 625PROSITE-ProRule annotation
Disulfide bondi633 ↔ 642PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ3U1J7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025473.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3U1J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 395Peptidase M12BInterPro annotationAdd BLAST200
Domaini403 – 489DisintegrinInterPro annotationAdd BLAST87
Domaini611 – 643EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
KOiK06540.
OMAiDENVQGC.
OrthoDBiEOG091G01NX.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3U1J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLWLLSVL WTPAVAPGPP LPHVKQYEVV WPRRLAASRS RRALPSHWGQ
60 70 80 90 100
YPESLSYALG TSGHVFTLHL RKNRDLLGSS YTETYSAANG SEVTEQLQEQ
110 120 130 140 150
DHCLYQGHVE GYEGSAASIS TCAGLRGFFR VGSTVHLIEP LDADEEGQHA
160 170 180 190 200
MYQAKHLQQK AGTCGVKDTN LNDLGPRALE IYRAQPRNWL IPRETRYVEL
210 220 230 240 250
YVVADSQEFQ KLGSREAVRQ RVLEVVNHVD KLYQELSFRV VLVGLEIWNK
260 270 280 290 300
DKFYISRYAN VTLENFLSWR EQNLQGQHPH DNVQLITGVD FIGSTVGLAK
310 320 330 340 350
VSALCSRHSG AVNQDHSKNS IGVASTMAHE LGHNLGMSHD EDIPGCYCPE
360 370 380 390 400
PREGGGCIMT ESIGSKFPRI FSRCSKIDLE SFVTKPQTGC LTNVPDVNRF
410 420 430 440 450
VGGPVCGNLF VEHGEQCDCG TPQDCQNPCC NATTCQLVKG AECASGTCCH
460 470 480 490 500
ECKVKPAGEV CRLSKDKCDL EEFCDGRKPT CPEDAFQQNG TPCPGGYCFD
510 520 530 540 550
GSCPTLAQQC RDLWGPGARV AADSCYTFSI PPGCNGRMYS GRINRCGALY
560 570 580 590 600
CEGGQKPLER SFCTFSSNHG VCHALGTGSN IDTFELVLQG TKCEEGKVCM
610 620 630 640 650
DGSCQDLRVY RSENCSAKCN NHGVCNHKRE CHCHKGWAPP NCVQRLADVS
660 670 680 690 700
DEQAASTSLP VSVVVVLVIL VAAMVIVAGI VIYRKAPRQI QRRSVAPKPI
710 720 730 740 750
SGLSNPLFYT RDSSLPAKNR PPDPSETVST NQPPRPIVKP KRPPPAPPGA
760 770 780 790 800
VSSSPLPVPV YAPKIPNQFR PDPPTKPLPE LKPKQVKPTF APPTPPVKPG
810 820
TGGTVPGATQ GAGEPKVALK VPIQKR
Length:826
Mass (Da):90,046
Last modified:October 11, 2005 - v1
Checksum:i3142CC81DBBADFB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150411 mRNA. Translation: BAE29535.1.
AK155912 mRNA. Translation: BAE33500.1.
CH466531 Genomic DNA. Translation: EDL17879.1.
RefSeqiNP_031429.1. NM_007403.3.
UniGeneiMm.15969.

Genome annotation databases

GeneIDi11501.
KEGGimmu:11501.

Similar proteinsi

Entry informationi

Entry nameiQ3U1J7_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation