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Protein

TCF3 fusion partner homolog

Gene

Tfpt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote apoptosis in a p53/TP53-independent manner.By similarity
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689603. UCH proteinases.
R-MMU-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
TCF3 fusion partner homolog
Alternative name(s):
Protein FB1
Protein amida
Gene namesi
Name:Tfpt
Synonyms:Amida
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916964. Tfpt.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002545821 – 259TCF3 fusion partner homologAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei172PhosphothreonineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei203PhosphothreonineBy similarity1
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3U1J1.
PaxDbiQ3U1J1.
PeptideAtlasiQ3U1J1.
PRIDEiQ3U1J1.

PTM databases

iPTMnetiQ3U1J1.
PhosphoSitePlusiQ3U1J1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006335.
CleanExiMM_TFPT.
ExpressionAtlasiQ3U1J1. baseline and differential.
GenevisibleiQ3U1J1. MM.

Interactioni

Subunit structurei

Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213632. 1 interactor.
IntActiQ3U1J1. 1 interactor.
STRINGi10090.ENSMUSP00000123636.

Structurei

3D structure databases

ProteinModelPortaliQ3U1J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXD0. Eukaryota.
ENOG4111UBX. LUCA.
GeneTreeiENSGT00390000016605.
HOGENOMiHOG000139148.
HOVERGENiHBG056588.
InParanoidiQ3U1J1.
KOiK11670.
OMAiYRASQLT.
OrthoDBiEOG091G0WHN.
PhylomeDBiQ3U1J1.
TreeFamiTF338152.

Family and domain databases

InterProiView protein in InterPro
IPR033555. TFPT.
PANTHERiPTHR35084. PTHR35084. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U1J1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGDSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRDSQFTIVL EDDGSQGTDV
160 170 180 190 200
PTPGNAENEP PEKEGLSPSQ RTTATLDPTS PAPGEGPSGR KRRRAPRVGA
210 220 230 240 250
SLTPELAPVQ VGAEGWGQGV IKVEEDFGFE ADEALDSSWV SREPDKLLPY

PTLASPPFD
Length:259
Mass (Da):28,954
Last modified:October 11, 2005 - v1
Checksum:iC5A0094DC93B356A
GO
Isoform 2 (identifier: Q3U1J1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-220: Missing.

Show »
Length:249
Mass (Da):28,013
Checksum:iA5D01527808DEA57
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021243211 – 220Missing in isoform 2. 3 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267988 mRNA. Translation: AAG48243.1.
AB035134 mRNA. Translation: BAB17318.1.
AK155925 mRNA. Translation: BAE33506.1.
BC024356 mRNA. Translation: AAH24356.1.
CCDSiCCDS20720.1. [Q3U1J1-2]
CCDS71873.1. [Q3U1J1-1]
RefSeqiNP_001277310.1. NM_001290381.1. [Q3U1J1-1]
NP_076013.1. NM_023524.2. [Q3U1J1-2]
UniGeneiMm.358730.

Genome annotation databases

EnsembliENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335. [Q3U1J1-1]
ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335. [Q3U1J1-2]
GeneIDi69714.
KEGGimmu:69714.
UCSCiuc009evf.2. mouse. [Q3U1J1-2]
uc009evg.2. mouse. [Q3U1J1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTFPT_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J1
Secondary accession number(s): Q9EP77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot