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Protein

TCF3 fusion partner homolog

Gene

Tfpt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote apoptosis in a p53/TP53-independent manner.By similarity
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
TCF3 fusion partner homolog
Alternative name(s):
Protein FB1
Protein amida
Gene namesi
Name:Tfpt
Synonyms:Amida
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916964. Tfpt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259TCF3 fusion partner homologPRO_0000254582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721PhosphothreonineBy similarity
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei188 – 1881PhosphoserineCombined sources
Modified residuei203 – 2031PhosphothreonineBy similarity
Modified residuei255 – 2551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3U1J1.
MaxQBiQ3U1J1.
PaxDbiQ3U1J1.
PRIDEiQ3U1J1.

PTM databases

iPTMnetiQ3U1J1.
PhosphoSiteiQ3U1J1.

Expressioni

Gene expression databases

BgeeiQ3U1J1.
CleanExiMM_TFPT.
ExpressionAtlasiQ3U1J1. baseline and differential.
GenevisibleiQ3U1J1. MM.

Interactioni

Subunit structurei

Interacts with NOL3; translocates NOL3 into the nucleus and negatively regulated TFPT-induced cell death. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213632. 1 interaction.
IntActiQ3U1J1. 1 interaction.
STRINGi10090.ENSMUSP00000123636.

Structurei

3D structure databases

ProteinModelPortaliQ3U1J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXD0. Eukaryota.
ENOG4111UBX. LUCA.
GeneTreeiENSGT00390000016605.
HOGENOMiHOG000139148.
HOVERGENiHBG056588.
InParanoidiQ3U1J1.
KOiK11670.
OMAiMRVLDAY.
OrthoDBiEOG76T9SH.
PhylomeDBiQ3U1J1.
TreeFamiTF338152.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U1J1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG
60 70 80 90 100
GLGDSGLRER DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL
110 120 130 140 150
NRLHQVQRIT RRLQQERRFL MRVLDSYGDD YRDSQFTIVL EDDGSQGTDV
160 170 180 190 200
PTPGNAENEP PEKEGLSPSQ RTTATLDPTS PAPGEGPSGR KRRRAPRVGA
210 220 230 240 250
SLTPELAPVQ VGAEGWGQGV IKVEEDFGFE ADEALDSSWV SREPDKLLPY

PTLASPPFD
Length:259
Mass (Da):28,954
Last modified:October 11, 2005 - v1
Checksum:iC5A0094DC93B356A
GO
Isoform 2 (identifier: Q3U1J1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-220: Missing.

Show »
Length:249
Mass (Da):28,013
Checksum:iA5D01527808DEA57
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei211 – 22010Missing in isoform 2. 3 PublicationsVSP_021243

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267988 mRNA. Translation: AAG48243.1.
AB035134 mRNA. Translation: BAB17318.1.
AK155925 mRNA. Translation: BAE33506.1.
BC024356 mRNA. Translation: AAH24356.1.
CCDSiCCDS20720.1. [Q3U1J1-2]
CCDS71873.1. [Q3U1J1-1]
RefSeqiNP_001277310.1. NM_001290381.1. [Q3U1J1-1]
NP_076013.1. NM_023524.2. [Q3U1J1-2]
UniGeneiMm.358730.

Genome annotation databases

EnsembliENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335. [Q3U1J1-1]
ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335. [Q3U1J1-2]
GeneIDi69714.
KEGGimmu:69714.
UCSCiuc009evf.2. mouse. [Q3U1J1-2]
uc009evg.2. mouse. [Q3U1J1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267988 mRNA. Translation: AAG48243.1.
AB035134 mRNA. Translation: BAB17318.1.
AK155925 mRNA. Translation: BAE33506.1.
BC024356 mRNA. Translation: AAH24356.1.
CCDSiCCDS20720.1. [Q3U1J1-2]
CCDS71873.1. [Q3U1J1-1]
RefSeqiNP_001277310.1. NM_001290381.1. [Q3U1J1-1]
NP_076013.1. NM_023524.2. [Q3U1J1-2]
UniGeneiMm.358730.

3D structure databases

ProteinModelPortaliQ3U1J1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213632. 1 interaction.
IntActiQ3U1J1. 1 interaction.
STRINGi10090.ENSMUSP00000123636.

PTM databases

iPTMnetiQ3U1J1.
PhosphoSiteiQ3U1J1.

Proteomic databases

EPDiQ3U1J1.
MaxQBiQ3U1J1.
PaxDbiQ3U1J1.
PRIDEiQ3U1J1.

Protocols and materials databases

DNASUi69714.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108641; ENSMUSP00000104281; ENSMUSG00000006335. [Q3U1J1-1]
ENSMUST00000155592; ENSMUSP00000123636; ENSMUSG00000006335. [Q3U1J1-2]
GeneIDi69714.
KEGGimmu:69714.
UCSCiuc009evf.2. mouse. [Q3U1J1-2]
uc009evg.2. mouse. [Q3U1J1-1]

Organism-specific databases

CTDi29844.
MGIiMGI:1916964. Tfpt.

Phylogenomic databases

eggNOGiENOG410IXD0. Eukaryota.
ENOG4111UBX. LUCA.
GeneTreeiENSGT00390000016605.
HOGENOMiHOG000139148.
HOVERGENiHBG056588.
InParanoidiQ3U1J1.
KOiK11670.
OMAiMRVLDAY.
OrthoDBiEOG76T9SH.
PhylomeDBiQ3U1J1.
TreeFamiTF338152.

Enzyme and pathway databases

ReactomeiR-MMU-5696394. DNA Damage Recognition in GG-NER.

Miscellaneous databases

PROiQ3U1J1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U1J1.
CleanExiMM_TFPT.
ExpressionAtlasiQ3U1J1. baseline and differential.
GenevisibleiQ3U1J1. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse ortholog of human FB1."
    Brambillasca F., Mosna G., Privitera E.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6 X CBA.
    Tissue: Lung.
  2. "Molecular cloning and functional analysis of mouse Amida."
    Miki N., Miyamoto K., Taira E.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ddY.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiTFPT_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J1
Secondary accession number(s): Q9EP77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.