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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

Slc38a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).By similarity

Enzyme regulationi

Not inhibited by lithium.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 5
Alternative name(s):
Solute carrier family 38 member 5
System N transporter 2
Gene namesi
Name:Slc38a5
Synonyms:Jm24, Sn2, Snat5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2148066. Slc38a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 84HelicalSequence analysisAdd BLAST23
Topological domaini85 – 97ExtracellularSequence analysisAdd BLAST13
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 135CytoplasmicSequence analysisAdd BLAST17
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 176ExtracellularSequence analysisAdd BLAST20
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 202CytoplasmicSequence analysis5
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 264ExtracellularSequence analysisAdd BLAST41
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 302CytoplasmicSequence analysisAdd BLAST17
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 341ExtracellularSequence analysisAdd BLAST18
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 406ExtracellularSequence analysis2
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 446CytoplasmicSequence analysisAdd BLAST19
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 479ExtracellularSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121161 – 479Sodium-coupled neutral amino acid transporter 5Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3U1J0.
PRIDEiQ3U1J0.

PTM databases

iPTMnetiQ3U1J0.
PhosphoSitePlusiQ3U1J0.

Expressioni

Inductioni

Down-regulated in Dgn3 deficient mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000031170.
CleanExiMM_SLC38A5.
ExpressionAtlasiQ3U1J0. baseline and differential.
GenevisibleiQ3U1J0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033512.

Structurei

3D structure databases

ProteinModelPortaliQ3U1J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ3U1J0.
KOiK14992.
OMAiAVGMEMQ.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ3U1J0.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U1J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAISCAVGME MQEPKMNGTL SAGAAAGYRQ EREGFLPTTR NPATGRKPVQ
60 70 80 90 100
FLDFEGKTSF GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL
110 120 130 140 150
LSSYSIHLLL TCASVVGIRA YEQLGQRAFG PAGKVVVAII ICLHNVGAMS
160 170 180 190 200
SYLFIIKSEL PLVIGTFLHM DPEGDWFLKG NLLIILVSLL IILPLALMKH
210 220 230 240 250
LGYLGYTSSL SLTCMLFFLI SVIYKKFQIG CDVSHNDTVV EAEQAPLQAF
260 270 280 290 300
NSSCEAELFT VDSQMSYTVP IMAFAFVCHP EVLPIYTELC RPTQRRMQAV
310 320 330 340 350
ANMSIGAMFI MYGLTATFGY LTFYSTVKAE MLEMYTQEDM LILCVRLAVL
360 370 380 390 400
LAVTLTVPVV LFPIRRALQQ LLFPSKAFSW LRHVAIALIL LILVNILVIC
410 420 430 440 450
VPTIRDIFGF IGSTSAPSLI FILPSVFYLR IVPTEVEPLF SWPKIQALCF
460 470
GVLGVLFMAI SLGFMFANWA TGQSRMSGH
Length:479
Mass (Da):52,617
Last modified:October 11, 2005 - v1
Checksum:i3B740701BB709ED9
GO
Isoform 2 (identifier: Q3U1J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Show »
Length:471
Mass (Da):51,884
Checksum:i10489D3A26BBFF1B
GO

Sequence cautioni

The sequence BAC35799 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35F → L in BAC36941 (PubMed:16141072).Curated1
Sequence conflicti209S → G in BAC35799 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0297031 – 8Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054485 mRNA. Translation: BAC35799.1. Different initiation.
AK077667 mRNA. Translation: BAC36941.1.
AK155928 mRNA. Translation: BAE33507.1.
AK158125 mRNA. Translation: BAE34371.1.
AL805902 Genomic DNA. Translation: CAM17938.1.
AL805902 Genomic DNA. Translation: CAM17940.1.
BC152401 mRNA. Translation: AAI52402.1.
CCDSiCCDS52990.1. [Q3U1J0-1]
RefSeqiNP_766067.2. NM_172479.3. [Q3U1J0-1]
UniGeneiMm.6055.

Genome annotation databases

EnsembliENSMUST00000033512; ENSMUSP00000033512; ENSMUSG00000031170. [Q3U1J0-1]
ENSMUST00000115590; ENSMUSP00000111253; ENSMUSG00000031170. [Q3U1J0-2]
ENSMUST00000115591; ENSMUSP00000111254; ENSMUSG00000031170. [Q3U1J0-2]
GeneIDi209837.
KEGGimmu:209837.
UCSCiuc009sos.2. mouse. [Q3U1J0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054485 mRNA. Translation: BAC35799.1. Different initiation.
AK077667 mRNA. Translation: BAC36941.1.
AK155928 mRNA. Translation: BAE33507.1.
AK158125 mRNA. Translation: BAE34371.1.
AL805902 Genomic DNA. Translation: CAM17938.1.
AL805902 Genomic DNA. Translation: CAM17940.1.
BC152401 mRNA. Translation: AAI52402.1.
CCDSiCCDS52990.1. [Q3U1J0-1]
RefSeqiNP_766067.2. NM_172479.3. [Q3U1J0-1]
UniGeneiMm.6055.

3D structure databases

ProteinModelPortaliQ3U1J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033512.

PTM databases

iPTMnetiQ3U1J0.
PhosphoSitePlusiQ3U1J0.

Proteomic databases

PaxDbiQ3U1J0.
PRIDEiQ3U1J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033512; ENSMUSP00000033512; ENSMUSG00000031170. [Q3U1J0-1]
ENSMUST00000115590; ENSMUSP00000111253; ENSMUSG00000031170. [Q3U1J0-2]
ENSMUST00000115591; ENSMUSP00000111254; ENSMUSG00000031170. [Q3U1J0-2]
GeneIDi209837.
KEGGimmu:209837.
UCSCiuc009sos.2. mouse. [Q3U1J0-1]

Organism-specific databases

CTDi92745.
MGIiMGI:2148066. Slc38a5.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ3U1J0.
KOiK14992.
OMAiAVGMEMQ.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ3U1J0.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ3U1J0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031170.
CleanExiMM_SLC38A5.
ExpressionAtlasiQ3U1J0. baseline and differential.
GenevisibleiQ3U1J0. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A5_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J0
Secondary accession number(s): Q3TZ39, Q8BJZ6, Q8BW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.