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Protein

Sodium-coupled neutral amino acid transporter 5

Gene

Slc38a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).By similarity

Enzyme regulationi

Not inhibited by lithium.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 5
Alternative name(s):
Solute carrier family 38 member 5
System N transporter 2
Gene namesi
Name:Slc38a5
Synonyms:Jm24, Sn2, Snat5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2148066. Slc38a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161CytoplasmicSequence analysisAdd
BLAST
Transmembranei62 – 8423HelicalSequence analysisAdd
BLAST
Topological domaini85 – 9713ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 13517CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 17620ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 2025CytoplasmicSequence analysis
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 26441ExtracellularSequence analysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Topological domaini286 – 30217CytoplasmicSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Topological domaini324 – 34118ExtracellularSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Topological domaini363 – 38321CytoplasmicSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 4062ExtracellularSequence analysis
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Topological domaini428 – 44619CytoplasmicSequence analysisAdd
BLAST
Transmembranei447 – 46721HelicalSequence analysisAdd
BLAST
Topological domaini468 – 47912ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Sodium-coupled neutral amino acid transporter 5PRO_0000312116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3U1J0.
PaxDbiQ3U1J0.
PRIDEiQ3U1J0.

PTM databases

PhosphoSiteiQ3U1J0.

Expressioni

Inductioni

Down-regulated in Dgn3 deficient mice.1 Publication

Gene expression databases

BgeeiQ3U1J0.
CleanExiMM_SLC38A5.
ExpressionAtlasiQ3U1J0. baseline and differential.
GenevisibleiQ3U1J0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033512.

Structurei

3D structure databases

ProteinModelPortaliQ3U1J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ3U1J0.
KOiK14992.
OMAiEMLEMYT.
PhylomeDBiQ3U1J0.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3U1J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAISCAVGME MQEPKMNGTL SAGAAAGYRQ EREGFLPTTR NPATGRKPVQ
60 70 80 90 100
FLDFEGKTSF GMSVFNLSNA IMGSGILGLA YAMAHTGVIF FLALLLCIAL
110 120 130 140 150
LSSYSIHLLL TCASVVGIRA YEQLGQRAFG PAGKVVVAII ICLHNVGAMS
160 170 180 190 200
SYLFIIKSEL PLVIGTFLHM DPEGDWFLKG NLLIILVSLL IILPLALMKH
210 220 230 240 250
LGYLGYTSSL SLTCMLFFLI SVIYKKFQIG CDVSHNDTVV EAEQAPLQAF
260 270 280 290 300
NSSCEAELFT VDSQMSYTVP IMAFAFVCHP EVLPIYTELC RPTQRRMQAV
310 320 330 340 350
ANMSIGAMFI MYGLTATFGY LTFYSTVKAE MLEMYTQEDM LILCVRLAVL
360 370 380 390 400
LAVTLTVPVV LFPIRRALQQ LLFPSKAFSW LRHVAIALIL LILVNILVIC
410 420 430 440 450
VPTIRDIFGF IGSTSAPSLI FILPSVFYLR IVPTEVEPLF SWPKIQALCF
460 470
GVLGVLFMAI SLGFMFANWA TGQSRMSGH
Length:479
Mass (Da):52,617
Last modified:October 11, 2005 - v1
Checksum:i3B740701BB709ED9
GO
Isoform 2 (identifier: Q3U1J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Show »
Length:471
Mass (Da):51,884
Checksum:i10489D3A26BBFF1B
GO

Sequence cautioni

The sequence BAC35799.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351F → L in BAC36941 (PubMed:16141072).Curated
Sequence conflicti209 – 2091S → G in BAC35799 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88Missing in isoform 2. 1 PublicationVSP_029703

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054485 mRNA. Translation: BAC35799.1. Different initiation.
AK077667 mRNA. Translation: BAC36941.1.
AK155928 mRNA. Translation: BAE33507.1.
AK158125 mRNA. Translation: BAE34371.1.
AL805902 Genomic DNA. Translation: CAM17938.1.
AL805902 Genomic DNA. Translation: CAM17940.1.
BC152401 mRNA. Translation: AAI52402.1.
CCDSiCCDS52990.1. [Q3U1J0-1]
RefSeqiNP_766067.2. NM_172479.3. [Q3U1J0-1]
UniGeneiMm.6055.

Genome annotation databases

EnsembliENSMUST00000033512; ENSMUSP00000033512; ENSMUSG00000031170. [Q3U1J0-1]
ENSMUST00000115590; ENSMUSP00000111253; ENSMUSG00000031170. [Q3U1J0-2]
ENSMUST00000115591; ENSMUSP00000111254; ENSMUSG00000031170. [Q3U1J0-2]
GeneIDi209837.
KEGGimmu:209837.
UCSCiuc009sos.2. mouse. [Q3U1J0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054485 mRNA. Translation: BAC35799.1. Different initiation.
AK077667 mRNA. Translation: BAC36941.1.
AK155928 mRNA. Translation: BAE33507.1.
AK158125 mRNA. Translation: BAE34371.1.
AL805902 Genomic DNA. Translation: CAM17938.1.
AL805902 Genomic DNA. Translation: CAM17940.1.
BC152401 mRNA. Translation: AAI52402.1.
CCDSiCCDS52990.1. [Q3U1J0-1]
RefSeqiNP_766067.2. NM_172479.3. [Q3U1J0-1]
UniGeneiMm.6055.

3D structure databases

ProteinModelPortaliQ3U1J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033512.

PTM databases

PhosphoSiteiQ3U1J0.

Proteomic databases

MaxQBiQ3U1J0.
PaxDbiQ3U1J0.
PRIDEiQ3U1J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033512; ENSMUSP00000033512; ENSMUSG00000031170. [Q3U1J0-1]
ENSMUST00000115590; ENSMUSP00000111253; ENSMUSG00000031170. [Q3U1J0-2]
ENSMUST00000115591; ENSMUSP00000111254; ENSMUSG00000031170. [Q3U1J0-2]
GeneIDi209837.
KEGGimmu:209837.
UCSCiuc009sos.2. mouse. [Q3U1J0-1]

Organism-specific databases

CTDi92745.
MGIiMGI:2148066. Slc38a5.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ3U1J0.
KOiK14992.
OMAiEMLEMYT.
PhylomeDBiQ3U1J0.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

NextBioi372814.
PROiQ3U1J0.
SOURCEiSearch...

Gene expression databases

BgeeiQ3U1J0.
CleanExiMM_SLC38A5.
ExpressionAtlasiQ3U1J0. baseline and differential.
GenevisibleiQ3U1J0. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Inner ear, Ovary and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice."
    Petri A., Ahnfelt-Roenne J., Frederiksen K.S., Edwards D.G., Madsen D., Serup P., Fleckner J., Heller R.S.
    J. Mol. Endocrinol. 37:301-316(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiS38A5_MOUSE
AccessioniPrimary (citable) accession number: Q3U1J0
Secondary accession number(s): Q3TZ39, Q8BJZ6, Q8BW30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.