ID   Q3U1H9_MOUSE            Unreviewed;       423 AA.
AC   Q3U1H9;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   24-JAN-2024, entry version 154.
DE   RecName: Full=Vasopressin V1a receptor {ECO:0000256|ARBA:ARBA00021173, ECO:0000256|RuleBase:RU046427};
GN   Name=Avpr1a {ECO:0000313|MGI:MGI:1859216};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE33518.1};
RN   [1] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [3] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [4] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [5] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [6] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [8] {ECO:0000313|EMBL:BAE33518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23266.1}, and NOD
RC   {ECO:0000313|EMBL:BAE33518.1};
RC   TISSUE=Activated spleen {ECO:0000313|EMBL:BAE33518.1}, and Urinary
RC   bladder {ECO:0000313|EMBL:BAE23266.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [9] {ECO:0007829|PubMed:17242355}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN   [10] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate a phosphatidyl-
CC       inositol-calcium second messenger system.
CC       {ECO:0000256|RuleBase:RU046427}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU046427}.
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DR   EMBL; AK137203; BAE23266.1; -; mRNA.
DR   EMBL; AK155952; BAE33518.1; -; mRNA.
DR   RefSeq; NP_058543.2; NM_016847.2.
DR   AlphaFoldDB; Q3U1H9; -.
DR   SMR; Q3U1H9; -.
DR   Antibodypedia; 29106; 329 antibodies from 35 providers.
DR   DNASU; 54140; -.
DR   GeneID; 54140; -.
DR   KEGG; mmu:54140; -.
DR   AGR; MGI:1859216; -.
DR   CTD; 552; -.
DR   MGI; MGI:1859216; Avpr1a.
DR   VEuPathDB; HostDB:ENSMUSG00000020123; -.
DR   HOGENOM; CLU_009579_15_3_1; -.
DR   OMA; FSMVEVN; -.
DR   OrthoDB; 2879183at2759; -.
DR   BioGRID-ORCS; 54140; 1 hit in 78 CRISPR screens.
DR   ExpressionAtlas; Q3U1H9; baseline and differential.
DR   GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0031894; F:V1A vasopressin receptor binding; IEA:Ensembl.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0042631; P:cellular response to water deprivation; IEA:Ensembl.
DR   GO; GO:0007625; P:grooming behavior; IEA:Ensembl.
DR   GO; GO:0002125; P:maternal aggressive behavior; IEA:Ensembl.
DR   GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR   GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
DR   GO; GO:0007621; P:negative regulation of female receptivity; IEA:Ensembl.
DR   GO; GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0032849; P:positive regulation of cellular pH reduction; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0014049; P:positive regulation of glutamate secretion; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:Ensembl.
DR   GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
DR   GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR   GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR   GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR   CDD; cd15385; 7tmA_V1aR; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR015076; V1R_C.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR001224; Vprs_V1A_rcpt.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF17; VASOPRESSIN V1A RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF08983; V1R_C; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00752; VASOPRSNV1AR.
DR   SMART; SM01164; DUF1856; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|RuleBase:RU046427};
KW   Glycoprotein {ECO:0000256|RuleBase:RU046427};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU046427};
KW   Transducer {ECO:0000256|RuleBase:RU046427};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU046427};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU046427}.
FT   TRANSMEM        55..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        88..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        126..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        221..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   DOMAIN          68..353
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47182 MW;  C75AFF1D0A082CC6 CRC64;
     MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL AKLEVTVLAV
     IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP
     DWLCRVVKHL QVFAMFASSY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWGLSFV
     LSIPQYFIFS VIEFEVNNGT KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF
     ICYHIWRNVR GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
     IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP WIYMFFSGHL
     LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT NSTGTWKDSP KSSKSIRFIP
     VST
//