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Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.UniRule annotation

GO - Molecular functioni

  1. peptide binding Source: GO_Central
  2. peptide hormone binding Source: Ensembl
  3. vasopressin receptor activity Source: GO_Central

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. cellular response to hormone stimulus Source: GO_Central
  3. cellular response to water deprivation Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: GO_Central
  5. grooming behavior Source: Ensembl
  6. maternal aggressive behavior Source: Ensembl
  7. maternal behavior Source: GO_Central
  8. myotube differentiation Source: Ensembl
  9. negative regulation of female receptivity Source: Ensembl
  10. negative regulation of transmission of nerve impulse Source: Ensembl
  11. penile erection Source: Ensembl
  12. positive regulation of cell growth Source: Ensembl
  13. positive regulation of cell proliferation Source: Ensembl
  14. positive regulation of cellular pH reduction Source: Ensembl
  15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  16. positive regulation of glutamate secretion Source: Ensembl
  17. positive regulation of heart rate Source: Ensembl
  18. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  19. positive regulation of renal sodium excretion Source: Ensembl
  20. positive regulation of systemic arterial blood pressure Source: Ensembl
  21. positive regulation of vasoconstriction Source: GO_Central
  22. regulation of systemic arterial blood pressure by vasopressin Source: MGI
  23. response to corticosterone Source: Ensembl
  24. response to peptide Source: GO_Central
  25. social behavior Source: Ensembl
  26. sperm ejaculation Source: Ensembl
  27. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptorUniRule annotation
Gene namesi
Name:Avpr1aImported
ORF Names:mCG_10108Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1859216. Avpr1a.

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7622HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 10619HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14823HelicalUniRule annotationAdd
BLAST
Transmembranei169 – 18921HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24626HelicalUniRule annotationAdd
BLAST
Transmembranei297 – 31721HelicalUniRule annotationAdd
BLAST
Transmembranei337 – 35620HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ3U1H9.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG105710.
KOiK04226.
OMAiTNSTGMW.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U1H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL
60 70 80 90 100
AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT
210 220 230 240 250
KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
310 320 330 340 350
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP
360 370 380 390 400
WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT
410 420
NSTGTWKDSP KSSKSIRFIP VST
Length:423
Mass (Da):47,182
Last modified:October 11, 2005 - v1
Checksum:iC75AFF1D0A082CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137203 mRNA. Translation: BAE23266.1.
AK155952 mRNA. Translation: BAE33518.1.
CH466578 Genomic DNA. Translation: EDL24431.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

Genome annotation databases

GeneIDi54140.
KEGGimmu:54140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137203 mRNA. Translation: BAE23266.1.
AK155952 mRNA. Translation: BAE33518.1.
CH466578 Genomic DNA. Translation: EDL24431.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54140.
KEGGimmu:54140.

Organism-specific databases

CTDi552.
MGIiMGI:1859216. Avpr1a.

Phylogenomic databases

HOVERGENiHBG105710.
KOiK04226.
OMAiTNSTGMW.

Miscellaneous databases

NextBioi310961.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ3U1H9.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  6. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported and Urinary bladderImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ3U1H9_MOUSE
AccessioniPrimary (citable) accession number: Q3U1H9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.