Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptorUniRule annotation
Gene namesi
Name:Avpr1aImported
ORF Names:mCG_10108Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1859216. Avpr1a.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei55 – 76HelicalUniRule annotationAdd BLAST22
Transmembranei88 – 106HelicalUniRule annotationAdd BLAST19
Transmembranei126 – 148HelicalUniRule annotationAdd BLAST23
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei221 – 246HelicalUniRule annotationAdd BLAST26
Transmembranei297 – 317HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 356HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000020123.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 353G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST286

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG105710.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3U1H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL
60 70 80 90 100
AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT
210 220 230 240 250
KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
310 320 330 340 350
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP
360 370 380 390 400
WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT
410 420
NSTGTWKDSP KSSKSIRFIP VST
Length:423
Mass (Da):47,182
Last modified:October 11, 2005 - v1
Checksum:iC75AFF1D0A082CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137203 mRNA. Translation: BAE23266.1.
AK155952 mRNA. Translation: BAE33518.1.
CH466578 Genomic DNA. Translation: EDL24431.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

Genome annotation databases

GeneIDi54140.
KEGGimmu:54140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137203 mRNA. Translation: BAE23266.1.
AK155952 mRNA. Translation: BAE33518.1.
CH466578 Genomic DNA. Translation: EDL24431.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020323.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54140.
KEGGimmu:54140.

Organism-specific databases

CTDi552.
MGIiMGI:1859216. Avpr1a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG105710.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020123.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U1H9_MOUSE
AccessioniPrimary (citable) accession number: Q3U1H9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.