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Protein

RuvB-like helicase

Gene

Ruvbl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotationSAAS annotation, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicaseUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:Ruvbl1Imported
ORF Names:mCG_130614Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1928760. Ruvbl1.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000030079.

Interactioni

Protein-protein interaction databases

MINTiMINT-8174156.
STRINGi10090.ENSMUSP00000032165.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 365AAAInterPro annotationAdd BLAST304

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1942. Eukaryota.
COG1224. LUCA.
HOVERGENiHBG054186.
KOiK04499.
OMAiYSTSDME.
OrthoDBiEOG091G07C9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3U1C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG
60 70 80 90 100
VIVELIKSKK MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE
110 120 130 140 150
VYSTEIKKTE VLMENFRRAI GLRIKETKEV YEGEVTELTP CETENPMGGY
160 170 180 190 200
GKTISHVIIG LKTAKGTKQL KLDPSIFESL QKERVEAGDV IYIEANSGAV
210 220 230 240 250
KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL HDLDVANARP
260 270 280 290 300
QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG VAELVPGVLF
310 320 330 340 350
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI
360 370 380 390 400
PLDLLDRVMI IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK
410 420 430 440 450
TTLRYSVQLL TPANLLAKIN GKDSIEKEHV EEISELFYDA KSSAKILADQ

QDKYMK
Length:456
Mass (Da):50,214
Last modified:October 11, 2005 - v1
Checksum:i9AE73EFFBA194BA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132783 mRNA. Translation: BAE21358.1.
AK156078 mRNA. Translation: BAE33576.1.
CH466523 Genomic DNA. Translation: EDK99249.1.
RefSeqiNP_062659.1. NM_019685.2.
UniGeneiMm.42195.

Genome annotation databases

GeneIDi56505.
KEGGimmu:56505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132783 mRNA. Translation: BAE21358.1.
AK156078 mRNA. Translation: BAE33576.1.
CH466523 Genomic DNA. Translation: EDK99249.1.
RefSeqiNP_062659.1. NM_019685.2.
UniGeneiMm.42195.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8174156.
STRINGi10090.ENSMUSP00000032165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56505.
KEGGimmu:56505.

Organism-specific databases

CTDi8607.
MGIiMGI:1928760. Ruvbl1.

Phylogenomic databases

eggNOGiKOG1942. Eukaryota.
COG1224. LUCA.
HOVERGENiHBG054186.
KOiK04499.
OMAiYSTSDME.
OrthoDBiEOG091G07C9.

Miscellaneous databases

ChiTaRSiRuvbl1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030079.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U1C2_MOUSE
AccessioniPrimary (citable) accession number: Q3U1C2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.