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Protein

Probable arginine--tRNA ligase, mitochondrial

Gene

Rars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144L-arginineBy similarity1
Binding sitei322L-arginineBy similarity1
Binding sitei326L-arginineBy similarity1
Binding sitei350L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:Rars2
Synonyms:Rarsl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1923596. Rars2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000025073217 – 578Probable arginine--tRNA ligase, mitochondrialAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3U186.
MaxQBiQ3U186.
PaxDbiQ3U186.
PeptideAtlasiQ3U186.
PRIDEiQ3U186.

PTM databases

iPTMnetiQ3U186.
PhosphoSitePlusiQ3U186.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028292.
ExpressionAtlasiQ3U186. baseline and differential.
GenevisibleiQ3U186. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029968.

Structurei

3D structure databases

ProteinModelPortaliQ3U186.
SMRiQ3U186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 135L-arginine bindingBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 144"HIGH" regionAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
GeneTreeiENSGT00530000063407.
HOGENOMiHOG000247211.
HOVERGENiHBG057355.
InParanoidiQ3U186.
KOiK01887.
OMAiHVKFGRI.
OrthoDBiEOG091G06CK.
PhylomeDBiQ3U186.
TreeFamiTF300888.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGFRRSIA CQLSRVLALP PESLIKSISA VPVSKKEEVA DFQLSVDSLL
60 70 80 90 100
EDNNHKSQVD TQDQARRLAE KLKCDTVVTA ISAGPRTLNF KINRELLTKA
110 120 130 140 150
VLQQVTEDGC KYGLKSELFS DLPKKRIVVE FSSPNIAKKF HVGHLRSTII
160 170 180 190 200
GNFIANLKEA LGHQVTRINY IGDWGMQFGL LGTGFQLFGY EEKLQTNPLQ
210 220 230 240 250
HLFDVYVQVN KEATDDKNVT KLAHEFFHRL EMGDTQALSL WQRFRDLSIE
260 270 280 290 300
EYTQIYKRLG IYFDEYSGES FYREKSQDVL KLLDSKGLLQ KTAEGNVVVD
310 320 330 340 350
LSGTGDLSSV CTVMRSDGTS LYATRDLAAA IHRMDKYNFD TMIYVADKGQ
360 370 380 390 400
RRHFQQVFQM LKIMGYDWAE RCQHVPFGIV KGMKTRRGGV TFLEDVLNEV
410 420 430 440 450
QSRMLQNMAS IKTTKQLENP QETAERVGLA AVIIQDFRGT LLSDYQFSWD
460 470 480 490 500
RVFQSRGDTG VFLQYTHARL CSLEETFGCG YLNDSNVACL QEPQSVSILQ
510 520 530 540 550
HLLRFDEVLY LSSQDLQPKH IVSYLLTLSH LAAVAHKTLQ VKDSPPDVAG
560 570
ARLHLFKAVR SVLANGMKLL GITPVCRM
Length:578
Mass (Da):65,336
Last modified:October 11, 2005 - v1
Checksum:i5255FAFA8F873C27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306D → G in AAH24878 (PubMed:15489334).Curated1
Sequence conflicti540Q → K in AAH24878 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156182 mRNA. Translation: BAE33614.1.
BC024878 mRNA. Translation: AAH24878.1.
CCDSiCCDS18029.1.
RefSeqiNP_852071.2. NM_181406.3.
UniGeneiMm.22363.

Genome annotation databases

EnsembliENSMUST00000029968; ENSMUSP00000029968; ENSMUSG00000028292.
GeneIDi109093.
KEGGimmu:109093.
UCSCiuc008sgf.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiSYRM_MOUSE
AccessioniPrimary (citable) accession number: Q3U186
Secondary accession number(s): Q8QZU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families