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Protein

Probable arginine--tRNA ligase, mitochondrial

Gene

Rars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144L-arginineBy similarity1
Binding sitei322L-arginineBy similarity1
Binding sitei326L-arginineBy similarity1
Binding sitei350L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:Rars2
Synonyms:Rarsl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1923596 Rars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000025073217 – 578Probable arginine--tRNA ligase, mitochondrialAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3U186
MaxQBiQ3U186
PaxDbiQ3U186
PeptideAtlasiQ3U186
PRIDEiQ3U186

PTM databases

iPTMnetiQ3U186
PhosphoSitePlusiQ3U186

Expressioni

Gene expression databases

BgeeiENSMUSG00000028292
ExpressionAtlasiQ3U186 baseline and differential
GenevisibleiQ3U186 MM

Interactioni

Protein-protein interaction databases

BioGridi224553, 1 interactor
STRINGi10090.ENSMUSP00000029968

Structurei

3D structure databases

ProteinModelPortaliQ3U186
SMRiQ3U186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 135L-arginine bindingBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 144"HIGH" regionAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1195 Eukaryota
COG0018 LUCA
GeneTreeiENSGT00530000063407
HOGENOMiHOG000247211
HOVERGENiHBG057355
InParanoidiQ3U186
KOiK01887
OMAiHGMSTRQ
OrthoDBiEOG091G06CK
PhylomeDBiQ3U186
TreeFamiTF300888

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGFRRSIA CQLSRVLALP PESLIKSISA VPVSKKEEVA DFQLSVDSLL
60 70 80 90 100
EDNNHKSQVD TQDQARRLAE KLKCDTVVTA ISAGPRTLNF KINRELLTKA
110 120 130 140 150
VLQQVTEDGC KYGLKSELFS DLPKKRIVVE FSSPNIAKKF HVGHLRSTII
160 170 180 190 200
GNFIANLKEA LGHQVTRINY IGDWGMQFGL LGTGFQLFGY EEKLQTNPLQ
210 220 230 240 250
HLFDVYVQVN KEATDDKNVT KLAHEFFHRL EMGDTQALSL WQRFRDLSIE
260 270 280 290 300
EYTQIYKRLG IYFDEYSGES FYREKSQDVL KLLDSKGLLQ KTAEGNVVVD
310 320 330 340 350
LSGTGDLSSV CTVMRSDGTS LYATRDLAAA IHRMDKYNFD TMIYVADKGQ
360 370 380 390 400
RRHFQQVFQM LKIMGYDWAE RCQHVPFGIV KGMKTRRGGV TFLEDVLNEV
410 420 430 440 450
QSRMLQNMAS IKTTKQLENP QETAERVGLA AVIIQDFRGT LLSDYQFSWD
460 470 480 490 500
RVFQSRGDTG VFLQYTHARL CSLEETFGCG YLNDSNVACL QEPQSVSILQ
510 520 530 540 550
HLLRFDEVLY LSSQDLQPKH IVSYLLTLSH LAAVAHKTLQ VKDSPPDVAG
560 570
ARLHLFKAVR SVLANGMKLL GITPVCRM
Length:578
Mass (Da):65,336
Last modified:October 11, 2005 - v1
Checksum:i5255FAFA8F873C27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306D → G in AAH24878 (PubMed:15489334).Curated1
Sequence conflicti540Q → K in AAH24878 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156182 mRNA Translation: BAE33614.1
BC024878 mRNA Translation: AAH24878.1
CCDSiCCDS18029.1
RefSeqiNP_852071.2, NM_181406.3
UniGeneiMm.22363

Genome annotation databases

EnsembliENSMUST00000029968; ENSMUSP00000029968; ENSMUSG00000028292
GeneIDi109093
KEGGimmu:109093
UCSCiuc008sgf.2 mouse

Entry informationi

Entry nameiSYRM_MOUSE
AccessioniPrimary (citable) accession number: Q3U186
Secondary accession number(s): Q8QZU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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